{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:56:44Z","timestamp":1791158204105,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.neulet.2008.03.062","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T12:30:57Z","timestamp":1207139457000},"page":"59-63","source":"Crossref","is-referenced-by-count":28,"title":["Increase in bax expression and apoptosis are associated in Huntington's disease progression"],"prefix":"10.1016","volume":"438","author":[{"given":"A.V.F.F.","family":"Teles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.R.","family":"Rosenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.A.","family":"Bertoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Smaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.03.062_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ceb.2006.10.004","article-title":"How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?","volume":"18","author":"Antignani","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neulet.2008.03.062_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3450271","article-title":"Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria","volume":"345","author":"Antonsson","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.neulet.2008.03.062_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","article-title":"p53 mediates cellular dysfunction and behavior abnormalities in Huntington's disease","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2008.03.062_bib4","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1471-4159.2005.03036.x","article-title":"Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's disease","volume":"93","author":"Brustovetsky","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2008.03.062_bib5","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.03.062_bib6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.cdd.4401508","article-title":"Bax affects intracellular Ca2+ sores and induces Ca2+ wave propagation","volume":"11","author":"Carvalho","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2008.03.062_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2008.03.062_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.immunol.16.1.395","article-title":"Bcl-2 family: regulators of cell death","volume":"16","author":"Chao","year":"1998","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.neulet.2008.03.062_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.200309146","article-title":"Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate","volume":"166","author":"Chen","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2008.03.062_bib10","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/sj.emboj.7601126","article-title":"Bcl-2 changes conformation to inhibit Bax oligomerization","volume":"25","author":"Dlugosz","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.neulet.2008.03.062_bib11","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/jnr.21258","article-title":"BH-3 only proteins Bid and BimEL are differentially involved in neuronal dysfunction in mouse models of Huntington's disease","volume":"85","author":"Garcia-Martinez","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2008.03.062_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0304-3940(91)90583-F","article-title":"Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease","volume":"133","author":"Hedreen","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.03.062_bib13","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1212\/WNL.43.12.2689","article-title":"Evidence for impairment of energy metabolism in vivo in Huntington's disease using located 1H NMR spectroscopy","volume":"43","author":"Jenkins","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2008.03.062_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10495-007-0722-z","article-title":"A tale of two mitochondrial channels, MAC and PTP, in apoptosis","volume":"12","author":"Kinnally","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.neulet.2008.03.062_bib15","first-page":"5501","article-title":"Immunohistochemical analysis of in vivo patterns of Bcl-X expression","volume":"54","author":"Krajewski","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.neulet.2008.03.062_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2008.03.062_bib17","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.embor.7400250","article-title":"Huntingtin and the molecular pathogenesis of Huntington's disease, fourth in molecular medicine review series","volume":"5","author":"Landles","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neulet.2008.03.062_bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin\u2013protein interactions and the pathogenesis of Huntington's disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.neulet.2008.03.062_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbabio.2004.05.011","article-title":"Mitochondrial alterations and apoptosis in smooth muscle from aged rats","volume":"1658","author":"Lopes","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2008.03.062_bib20","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington's disease","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2008.03.062_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.03.062_bib22","doi-asserted-by":"crossref","first-page":"34785","DOI":"10.1074\/jbc.M603845200","article-title":"Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences","volume":"281","author":"Milakovic","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2008.03.062_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.03.062_bib24","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1083\/jcb.153.6.1265","article-title":"Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis","volume":"153","author":"Nechushtan","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2008.03.062_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0092-8674(87)90448-X","article-title":"Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma","volume":"49","author":"Negrini","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.03.062_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"74","author":"Oltvai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.03.062_bib27","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1073\/pnas.95.4.1455","article-title":"Bcl-2 prevents apoptotic mitochondrial dysfunction by regulation proton flux","volume":"95","author":"Schimizu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neulet.2008.03.062_bib28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0006-291X(03)00615-6","article-title":"Mechanisms of cytochrome c release by proapoptotic BCL-2 family members","volume":"304","author":"Scorrano","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2008.03.062_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0100-879X2003000200004","article-title":"Mitochondria, calcium and proapoptotic proteins as mediators in cell death signaling","volume":"36","author":"Smaili","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neulet.2008.03.062_bib30","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neulet.2008.03.062_bib31","doi-asserted-by":"crossref","first-page":"16899","DOI":"10.1073\/pnas.242603899","article-title":"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences","volume":"99","author":"Strausberg","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neulet.2008.03.062_bib32","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1242\/jcs.00829","article-title":"Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance","volume":"116","author":"Thomenius","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neulet.2008.03.062_bib33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-004-0957-5","article-title":"Expression pattern of apoptosis-related markers in Huntington's disease","volume":"109","author":"Vis","year":"2005","journal-title":"Acta Neuropatol."},{"key":"10.1016\/j.neulet.2008.03.062_bib34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.0305-1846.2001.00305.x","article-title":"The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum","volume":"27","author":"Vis","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neulet.2008.03.062_bib35","first-page":"2922","article-title":"The expanding role of mitochondria in apoptosis","volume":"15","author":"Wang","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2008.03.062_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bbrc.2005.04.013","article-title":"p53 in apoptosis control: an introduction","volume":"331","author":"Zamzami","year":"2005","journal-title":"Biochem. Biophys Res. Commun."},{"key":"10.1016\/j.neulet.2008.03.062_bib37","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1046\/j.1471-4159.2003.02105.x","article-title":"Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease","volume":"87","author":"Zhang","year":"2003","journal-title":"J. Neurochem."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008003650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008003650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T16:26:55Z","timestamp":1557419215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008003650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0304394008003650"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.03.062","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}