{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:00:53Z","timestamp":1768345253577,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.neulet.2008.05.007","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T05:34:04Z","timestamp":1210311244000},"page":"160-164","source":"Crossref","is-referenced-by-count":25,"title":["Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia"],"prefix":"10.1016","volume":"439","author":[{"given":"Yuming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.Y.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dickson T.K.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson T.K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanping","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.05.007_bib1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","article-title":"Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination","volume":"17","author":"Bederson","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2008.05.007_bib2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/01.STR.0000125855.17686.6d","article-title":"Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol","volume":"35","author":"Culmsee","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2008.05.007_bib3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s007010050491","article-title":"Protective effects of memantine against ischemia-reperfusion injury in spontaneously hypertensive rats","volume":"141","author":"Dogan","year":"1999","journal-title":"Acta Neurochir. (Wien)"},{"key":"10.1016\/j.neulet.2008.05.007_bib4","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1161\/01.STR.28.4.866","article-title":"Characterizing the target of acute stroke therapy","volume":"28","author":"Fisher","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2008.05.007_bib5","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1021\/pr060615g","article-title":"Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons","volume":"6","author":"Fu","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.neulet.2008.05.007_bib6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/j.1471-4159.2006.03960.x","article-title":"Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels","volume":"98","author":"Fu","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2008.05.007_bib7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00004647-200206000-00008","article-title":"Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors","volume":"22","author":"Giovannelli","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2008.05.007_bib8","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s007010070027","article-title":"Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat","volume":"142","author":"Gorgulu","year":"2000","journal-title":"Acta Neurochir. (Wien)"},{"key":"10.1016\/j.neulet.2008.05.007_bib9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.drudis.2006.06.001","article-title":"Therapeutic strategies for the treatment of stroke","volume":"11","author":"Green","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.neulet.2008.05.007_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1124\/jpet.301.1.210","article-title":"Neuroprotective effect of (2S,3S,4R)-N-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2Hbenzopyran-4-yl)-N-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats","volume":"301","author":"Hong","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2008.05.007_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neulet.2006.06.003","article-title":"Selective alteration of expression of Na(+)\/Ca(2+) exchanger isoforms after transient focal cerebral ischemia in rats","volume":"404","author":"Li","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.05.007_bib12","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1124\/mol.106.029108","article-title":"Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-d-aspartate receptors and neuronal nitric-oxide synthase","volume":"71","author":"Li","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2008.05.007_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.wnr.0000209014.09094.72","article-title":"Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine","volume":"17","author":"Li","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2008.05.007_bib14","doi-asserted-by":"crossref","first-page":"18179","DOI":"10.1074\/jbc.M411085200","article-title":"Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-d-aspartate receptors","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2008.05.007_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature (London)"},{"key":"10.1016\/j.neulet.2008.05.007_bib16","doi-asserted-by":"crossref","first-page":"23646","DOI":"10.1074\/jbc.271.39.23646","article-title":"Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease","volume":"271","author":"Pang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2008.05.007_bib17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0278-5846(01)00332-3","article-title":"The effects of NMDA receptor antagonist MK-801 on lipid peroxidation during focal cerebral ischemia in rats","volume":"26","author":"Serteser","year":"2002","journal-title":"Neuropsychopharmacol. Biol. Psychiat."},{"key":"10.1016\/j.neulet.2008.05.007_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(99)00214-9","article-title":"Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat","volume":"375","author":"Stieg","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2008.05.007_bib19","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1161\/01.STR.30.12.2752","article-title":"Recommendations for standards regarding preclinical neuroprotective and restorative drug development","volume":"30","author":"Stroke Therapy Academic Industry Roundtable (STAIR)","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2008.05.007_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3940(00)01198-8","article-title":"Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor","volume":"288","author":"Wu","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.05.007_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0304-3940(00)01357-4","article-title":"Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine","volume":"290","author":"Xiao","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.05.007_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0169-328X(01)00135-8","article-title":"DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats","volume":"91","author":"Yao","year":"2001","journal-title":"Brain Res. Mol. Brain. Res."},{"key":"10.1016\/j.neulet.2008.05.007_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tips.2004.11.007","article-title":"Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders","volume":"26","author":"Youdim","year":"2005","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.neulet.2008.05.007_bib24","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1016\/j.febslet.2005.09.006","article-title":"One-compound\u2013multiple-targets strategy to combat Alzheimer's disease","volume":"579","author":"Zhang","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neulet.2008.05.007_bib25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1124\/jpet.105.098517","article-title":"2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia","volume":"317","author":"Zhang","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008006137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008006137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T18:20:48Z","timestamp":1546021248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008006137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0304394008006137"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.05.007","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}