{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:43:34Z","timestamp":1784097814457,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016967","name":"Ministerio de Educaci\u00f3n Superior, Ciencia y Tecnolog\u00eda, Rep\u00fablica Dominicana","doi-asserted-by":"publisher","award":["AGL-04-7935-C03-02"],"award-info":[{"award-number":["AGL-04-7935-C03-02"]}],"id":[{"id":"10.13039\/100016967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.neulet.2008.09.022","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T13:01:49Z","timestamp":1221742909000},"page":"143-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia\u2013reoxygenation"],"prefix":"10.1016","volume":"446","author":[{"given":"Jos\u00e9 Antonio","family":"Gonz\u00e1lez-Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Navas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Lopez-Villodres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Espartero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"De La Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.09.022_bib1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.ejcn.1601575","article-title":"Mediterranean diet and all-causes mortality after myocardial infarction: results from the GISSI-Prevenzione trial","volume":"57","author":"Barzi","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.neulet.2008.09.022_bib2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/jn\/135.6.1475","article-title":"Hydrolyzed olive vegetation water in mice has anti-inflammatory activity","volume":"135","author":"Bitler","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.neulet.2008.09.022_bib3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neulet.2006.08.094","article-title":"Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats","volume":"414","author":"Bu","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.09.022_bib4","first-page":"1492","article-title":"Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil","volume":"29","author":"D\u2019Angelo","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neulet.2008.09.022_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(01)02475-2","article-title":"Effects of S-adenosyl-l-methionine on lipid peroxidation and glutathione levels in rat brain slices exposed to reoxygenation after oxygen\u2013glucose deprivation","volume":"318","author":"De La Cruz","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2008.09.022_bib6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0735-1097(96)00280-X","article-title":"Effect of a Mediterranean type diet on the rate of cardiovascular complications in patients with coronary artery disease","volume":"28","author":"de Lorgril","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.neulet.2008.09.022_bib7","first-page":"375","article-title":"Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review","volume":"43","author":"Fit\u00f3","year":"2007","journal-title":"Ann. Ist. Super Sanita"},{"key":"10.1016\/j.neulet.2008.09.022_bib8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s11745-007-3097-6","article-title":"Dietary virgin olive oil reduces oxidative stress and cellular damage in rat brain slices subjected to hypoxia\u2013reoxygenation","volume":"42","author":"Gonz\u00e1lez-Correa","year":"2007","journal-title":"Lipids"},{"key":"10.1016\/j.neulet.2008.09.022_bib9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/jf000537w","article-title":"Antioxidant activity of hydroxytyrosol acetate compared with that of other olive oil polyphenols","volume":"49","author":"Gordon","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neulet.2008.09.022_bib10","series-title":"Seven Countries: A Multivariate Analysis of Diet and Coronary Heart Disease","author":"Keys","year":"1980"},{"key":"10.1016\/j.neulet.2008.09.022_bib11","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/sj.ejcn.1602378","article-title":"Comparison of three different dietary scores in relation to 10-year mortality in elderly European subjects: the HALE project","volume":"60","author":"Knoops","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.neulet.2008.09.022_bib12","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1161\/01.STR.31.11.2751","article-title":"AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association","volume":"31","author":"Krauss","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2008.09.022_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1079\/PHN2005935","article-title":"The SUN cohort study (Seguimiento University of Navarra)","volume":"9","author":"Martinez-Gonzalez","year":"2006","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.neulet.2008.09.022_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopha.2005.03.005","article-title":"SOD, oxidative stress and human pathologies: a brief history and a future vision","volume":"59","author":"McCord","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neulet.2008.09.022_bib15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0028-3908(99)00226-9","article-title":"Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices","volume":"39","author":"Moro","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2008.09.022_bib16","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/jf0703710","article-title":"Hydroxytyrosol-rich olive mill wastewater protects brain cells in vitro and ex vivo","volume":"55","author":"Schaffer","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neulet.2008.09.022_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1385\/MN:31:1-3:135","article-title":"Polyphenols in cerebral ischemia: novel targets for neuroprotection","volume":"31","author":"Simonyi","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2008.09.022_bib18","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1136\/bmj.38415.644155.8F","article-title":"Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study","volume":"330","author":"Trichopoulou","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.neulet.2008.09.022_bib19","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1021\/jf060520z","article-title":"Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems","volume":"54","author":"Trujillo","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neulet.2008.09.022_bib20","first-page":"895","article-title":"Antioxidants and cardiovascular disease","volume":"6","author":"Violi","year":"2005","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.neulet.2008.09.022_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/med.1028","article-title":"Antioxidant and other biological activities of phenols from olives and olive oil","volume":"22","author":"Visioli","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.neulet.2008.09.022_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","article-title":"The inflammatory response in stroke","volume":"184","author":"Wang","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neulet.2008.09.022_bib23","unstructured":"World Health Organization Study Group, Diet, Nutrition, and the Prevention of Chronic Diseases, Technical Report Series 916, World Health Organization, Geneva, Switzerland, 2003."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008012664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008012664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:07:53Z","timestamp":1759608473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008012664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":23,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0304394008012664"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.09.022","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia\u2013reoxygenation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2008.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}