{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:20Z","timestamp":1786994780697,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.neulet.2008.09.065","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T05:34:13Z","timestamp":1222839253000},"page":"78-81","source":"Crossref","is-referenced-by-count":17,"title":["Cell-type-specific alternative splicing in spinocerebellar ataxia type 6"],"prefix":"10.1016","volume":"447","author":[{"given":"Taiji","family":"Tsunemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinya","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.09.065_bib1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/514867","article-title":"Japanese families with autosomal dominant pure cerebellar ataxia map to chromosome 19p13.1-p13.2 and are strongly associated with mild CAG expansions in the spinocerebellar ataxia type 6 gene in chromosome 19p13.1","volume":"61","author":"Ishikawa","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/hmg\/8.7.1185","article-title":"Abundant expression and cytoplasmic aggregations of [alpha]1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6","volume":"8","author":"Ishikawa","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/jnnp.67.1.86","article-title":"Clinical, neuropathological, and molecular study in two families with spinocerebellar ataxia type 6 (SCA6)","volume":"67","author":"Ishikawa","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2008.09.065_bib4","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/hmg\/ddg352","article-title":"Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis","volume":"12","author":"Kennedy","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/hmg\/ddl080","article-title":"C-termini of P\/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity","volume":"15","author":"Kordasiewicz","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib6","doi-asserted-by":"crossref","first-page":"RC14","DOI":"10.1523\/JNEUROSCI.19-12-j0004.1999","article-title":"Direct alteration of the P\/Q-type Ca2+ channel property by polyglutamine expansion in spinocerebellar ataxia 6","volume":"19","author":"Matsuyama","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.09.065_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/01.jnen.0000240474.27791.f3","article-title":"RNA in brain disease: no longer just \u201cthe messenger in the middle\u201d","volume":"66","author":"Nelson","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2008.09.065_bib8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"Orr","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2008.09.065_bib9","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.21-23-09185.2001","article-title":"Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6","volume":"21","author":"Piedras-Renteria","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.09.065_bib10","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1523\/JNEUROSCI.20-17-06394.2000","article-title":"The polyglutamine expansion in spinocerebellar ataxia type 6 causes a beta subunit-specific enhanced activation of P\/Q-type calcium channels in Xenopus oocytes","volume":"20","author":"Restituito","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.09.065_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mcn.2006.11.006","article-title":"Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells","volume":"34","author":"Saegusa","year":"2007","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.neulet.2008.09.065_bib12","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1074\/jbc.275.15.10893","article-title":"Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function","volume":"275","author":"Toru","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2008.09.065_bib13","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1074\/jbc.M108222200","article-title":"Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current","volume":"277","author":"Tsunemi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2008.09.065_bib14","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/hmg\/ddg300","article-title":"Regional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1","volume":"12","author":"Watase","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib15","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1371\/journal.pgen.0030109","article-title":"Modulating the expression of disease genes with RNA-based therapy","volume":"3","author":"Wood","year":"2007","journal-title":"PLos Genet."},{"key":"10.1016\/j.neulet.2008.09.065_bib16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1440-1789.2006.00670.x","article-title":"Polyglutamine disease: recent advances in the neuropathology of dentatorubral-pallidoluysian atrophy","volume":"26","author":"Yamada","year":"2006","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2008.09.065_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0197-62","article-title":"Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel","volume":"15","author":"Zhuchenko","year":"1997","journal-title":"Nat. Genet."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008013098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008013098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T06:25:15Z","timestamp":1557815115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008013098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0304394008013098"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.09.065","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}