{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:30Z","timestamp":1791274590861,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.neulet.2008.12.051","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T08:50:57Z","timestamp":1231318257000},"page":"28-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction"],"prefix":"10.1016","volume":"452","author":[{"given":"Amy M.","family":"Ritter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Thorneloe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.12.051_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/9195","article-title":"The tetrodotoxin-resistant sodium channel SNS has a specialized junction in pain pathways","volume":"2","author":"Akopian","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib2","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1523\/JNEUROSCI.4015-06.2006","article-title":"The voltage-gated sodium channel Nav 1.9 is an effector of peripheral inflammatory pain hypersensitivity","volume":"26","author":"Amaya","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0306-4522(01)00496-1","article-title":"Vanilloid Receptor 1 expression in the rat urinary tract","volume":"109","author":"Avelina","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2008.12.051_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1113\/jphysiol.2005.089771","article-title":"Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurons","volume":"567","author":"Baker","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpuro0672","article-title":"Mechanisms of disease: involvement of the urothelium in bladder dysfunction","volume":"4","author":"Birder","year":"2007","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.neulet.2008.12.051_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0006-8993(02)03957-4","article-title":"Tetrodotoxin-resistant sodium channels Nav 1.8\/SNS and Nav 1.9\/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats","volume":"963","author":"Black","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2008.12.051_bib7","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1523\/JNEUROSCI.22-23-10277.2002","article-title":"Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons","volume":"22","author":"Blair","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/18906","article-title":"A capsaicin-receptor homologue with a high threshold for noxious heat","volume":"398","author":"Caterina","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2008.12.051_bib9","doi-asserted-by":"crossref","first-page":"RC43","DOI":"10.1523\/JNEUROSCI.19-24-j0001.1999","article-title":"A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons","volume":"19","author":"Cummins","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.2003.042127","article-title":"The TTX-resistant sodium channel Na(v)1.8(SNS\/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons","volume":"550","author":"Djouhri","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib11","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1139\/y92-206","article-title":"Mechanoreceptive afferent activity compared with receptor field dimensions and pressure changes in feline urinary-bladder","volume":"70","author":"Downie","year":"1992","journal-title":"Can. J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib12","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.1072-06.2006","article-title":"Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav 1.9 expression","volume":"26","author":"Fang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib13","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1152\/jn.2002.88.3.1512","article-title":"Prostaglandin E-2 modulated TTX-R I-Na in rat colonic sensory neurons","volume":"88","author":"Gold","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1113\/jphysiol.1990.sp018117","article-title":"Activation of unmyelinated afferent-fibers by mechanical stimuli and inflammation of the urinary-bladder in the cat","volume":"425","author":"Habler","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1152\/jn.1993.69.2.395","article-title":"Receptive properties of myelinated primary afferents innervating the inflamed urinary bladder of the cat","volume":"69","author":"Habler","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.1993.sp019604","article-title":"Myelinated primary afferents of the sacral spinal cord responding to slow filling and distention of the cat urinary bladder","volume":"463","author":"Habler","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib17","doi-asserted-by":"crossref","first-page":"R574","DOI":"10.1152\/ajpregu.00465.2002","article-title":"COX-2 and prostaniod expression in micturation pathways after cyclophosphamide-induced cyctitis in the rat","volume":"284","author":"Hu","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1442-2042.2005.01140.x","article-title":"Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom","volume":"12","author":"Kim","year":"2005","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.neulet.2008.12.051_bib19","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0022-5347(05)00992-4","article-title":"Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder","volume":"175","author":"Kim","year":"2006","journal-title":"J. Urol."},{"key":"10.1016\/j.neulet.2008.12.051_bib20","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1016\/0306-4522(81)90088-9","article-title":"Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents","volume":"6","author":"Kostyuk","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2008.12.051_bib21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.1965.45.3.425","article-title":"Nervous control of micturition","volume":"45","author":"Kuru","year":"1965","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2008.12.051_bib22","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1523\/JNEUROSCI.22-19-08352.2002","article-title":"Deficits in visceral pain and referred hyperalgesia in Nav 1.8 (SNS\/PN3)-null mice","volume":"22","author":"Laird","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib23","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.juro.2006.11.072","article-title":"Cyclophosphamide induced cystitis: role of nitric oxide synthetase, cyclooxygenase-1 and 2, and NK1 receptors","volume":"117","author":"Linares-Fernandez","year":"2007","journal-title":"J. Urol."},{"key":"10.1016\/j.neulet.2008.12.051_bib24","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1097\/00001756-200412030-00008","article-title":"Colonic inflammation increases Na+ currents in bladder sensory neurons","volume":"15","author":"Malykhina","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2008.12.051_bib25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ejpain.2007.12.011","article-title":"Lack of colonic inflammation-induced visceral hypersensitivity to colorectal distension in Nav 1.9 knockout mice","volume":"12","author":"Martinez","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2008.12.051_bib26","doi-asserted-by":"crossref","first-page":"R507","DOI":"10.1152\/ajprenal.00054.2008","article-title":"Enhanced bladder capacity and reduced prostaglandin E2 mediated bladder hyperactivity in EP3 receptor knock-out mice","volume":"295","author":"McCafferty","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib27","first-page":"R695","article-title":"Pressure, volume, and chemosensitivity in afferent innervation of urinary bladder in rats","volume":"272","author":"Moss","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib28","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1073\/pnas.0501549102","article-title":"Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav 1.9 to sensory transmission and nociceptive behavior","volume":"102","author":"Priest","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.neulet.2008.12.051_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","article-title":"Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons","volume":"86","author":"Renganathan","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2006.121483","article-title":"Multiple sodium channels and their role in electrogenesis within dorsal root ganglion neurons","author":"Rush","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.brainres.2004.07.042","article-title":"PGE2 increases the tetrodotoxin-resistant Nav 1.9 sodium current in mouse DRG neurons via G-proteins","volume":"1023","author":"Rush","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2008.12.051_bib32","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/01.ju.0000134186.58854.2c","article-title":"Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice","volume":"172","author":"Schr\u00f6der","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.neulet.2008.12.051_bib33","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1152\/jn.1994.72.5.2420","article-title":"Mechanosensitive properties of pelvic nerve afferents innervating the urinary-bladder of the rat","volume":"72","author":"Sengupta","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib34","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1152\/jn.2000.84.4.1924","article-title":"Sensory fibers of the pelvic nerve innervating the rat's urinary bladder","volume":"84","author":"Shea","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib35","first-page":"C1744","article-title":"Mouse colon sensory neurons detect extracellular acidosis via TRPV1","volume":"297","author":"Sugiura","year":"2007","journal-title":"Am. J. Physiol. Cell Biol."},{"key":"10.1016\/j.neulet.2008.12.051_bib36","doi-asserted-by":"crossref","first-page":"F604","DOI":"10.1152\/ajprenal.00060.2005","article-title":"Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder","volume":"289","author":"Thorneloe","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.neulet.2008.12.051_bib37","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1073\/pnas.94.4.1527","article-title":"Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons","volume":"94","author":"Toledo-Aral","year":"1997","journal-title":"PNAS"},{"key":"10.1016\/j.neulet.2008.12.051_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(90)91693-B","article-title":"Conduction velocity distribution of afferent-fibers innervating the rat urinary-bladder","volume":"520","author":"Vera","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2008.12.051_bib39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1152\/jn.01049.2007","article-title":"Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents","volume":"99","author":"Xu","year":"2008","journal-title":"J. Neurophysiol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008017497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008017497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:08:39Z","timestamp":1759608519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008017497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0304394008017497"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.12.051","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2008.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}