{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:24:09Z","timestamp":1792203849087,"version":"4.4.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.neulet.2009.01.018","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T09:23:41Z","timestamp":1231925021000},"page":"212-216","source":"Crossref","is-referenced-by-count":18,"title":["Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter"],"prefix":"10.1016","volume":"451","author":[{"given":"Xuan-Chuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Oldham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Buxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Nghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Lanthorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bomont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2009.01.018_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0006-8993(97)00721-X","article-title":"Proline-induced inhibition of glutamate release in hippocampal area CA1","volume":"769","author":"Cohen","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2009.01.018_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0006-8993(97)00352-1","article-title":"Proline-induced potentiation of glutamate transmission","volume":"761","author":"Cohen","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2009.01.018_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/mcne.1998.0727","article-title":"Localization of the brain-specific high-affinity l-proline transporter in cultured hippocampal neurons: molecular heterogeneity of synaptic terminals","volume":"13","author":"Crump","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2009.01.018_bib4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0896-6273(92)90206-S","article-title":"Molecular cloning and expression of a high affinity l-proline transporter expressed in putative glutamatergic pathways of rat brain","volume":"8","author":"Fremeau","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2009.01.018_bib5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0026-895X(25)08986-2","article-title":"A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity l-proline transporter","volume":"49","author":"Fremeau","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2009.01.018_bib6","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1523\/JNEUROSCI.19-15-06290.1999","article-title":"L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain l-proline transporter","volume":"19","author":"Galli","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.01.018_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/325529a0","article-title":"Glycine potentiates the NMDA response in cultured mouse brain neurons","volume":"325","author":"Johnson","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2009.01.018_bib8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1126\/science.2841759","article-title":"Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes","volume":"241","author":"Kleckner","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neulet.2009.01.018_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1124\/mol.61.4.885","article-title":"Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism","volume":"61","author":"Lin","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2009.01.018_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0014-2999(92)90580-W","article-title":"NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells","volume":"219","author":"Martin","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2009.01.018_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1523\/JNEUROSCI.19-01-00021.1999","article-title":"The mammalian brain high-affinity l-proline transporter is enriched preferentially in synaptic vesicles in a subpopulation of excitatory nerve terminals in rat forebrain","volume":"19","author":"Renick","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.01.018_bib12","doi-asserted-by":"crossref","first-page":"12233","DOI":"10.1016\/S0021-9258(17)44162-7","article-title":"Selective inhibition of synaptosomal proline uptake by leucine and methionine enkephalins","volume":"258","author":"Rhoads","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.01.018_bib13","series-title":"Neurotransmitter Transporters","first-page":"25","article-title":"Mechanisms of biogenic amine neurotransmitter transporters","author":"Rudnick","year":"2002"},{"key":"10.1016\/j.neulet.2009.01.018_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0026-895X(25)10240-X","article-title":"Human brain-specific l-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes","volume":"48","author":"Shafqat","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2009.01.018_bib15","first-page":"367","article-title":"Putative neurotransmitters in the brain: selective neuronal uptake, subcellular localization, and interactions with centrally acting drugs","volume":"2","author":"Snyder","year":"1970","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2009.01.018_bib16","doi-asserted-by":"crossref","first-page":"15755","DOI":"10.1074\/jbc.270.26.15755","article-title":"Mammalian brain-specific l-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes","volume":"270","author":"Velaz-Faircloth","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.01.018_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature03978","article-title":"Crystal structure of a bacterial homologue of Na+\/Cl-dependent neurotransmitter transporters","volume":"437","author":"Yamashita","year":"2005","journal-title":"Nature"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394009000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394009000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:06:44Z","timestamp":1738883204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394009000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0304394009000408"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2009.01.018","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}