{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:00:07Z","timestamp":1776189607394,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.neulet.2009.02.041","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T11:46:24Z","timestamp":1235475984000},"page":"219-224","source":"Crossref","is-referenced-by-count":12,"title":["Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus"],"prefix":"10.1016","volume":"453","author":[{"given":"Peter J.","family":"Bergold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valariya","family":"Pinkhasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jozwicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy D.","family":"Coplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Dow-Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 A.","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2009.02.041_bib1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1176\/ajp.155.9.1178","article-title":"Cerebral glucose metabolism in women with panic disorder","volume":"155","author":"Bisaga","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-3999(97)00203-1","article-title":"Neurobiology of panic disorder","volume":"44","author":"Bourin","year":"1998","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.neulet.2009.02.041_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1586\/14737175.4.2.275","article-title":"Brain imaging in anxiety disorders","volume":"4","author":"Bremner","year":"2004","journal-title":"Exp. Rev. Neurother."},{"key":"10.1016\/j.neulet.2009.02.041_bib4","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.lfs.2005.11.028","article-title":"Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity","volume":"78","author":"Busnello","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2009.02.041_bib5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.neuint.2005.12.036","article-title":"The redox switch\/redox coupling hypothesis","volume":"48","author":"Cerdan","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2009.02.041_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-3223(92)90200-J","article-title":"Noradrenergic function in panic disorder. Effects of intravenous clonidine pretreatment on lactate induced panic","volume":"31","author":"Coplan","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0006-3223(91)90069-X","article-title":"Lactate vulnerability after alprazolam versus placebo","volume":"30","author":"Cowley","year":"1991","journal-title":"Biol. Psych."},{"key":"10.1016\/j.neulet.2009.02.041_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0925-4927(97)00066-8","article-title":"Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic","volume":"76","author":"Dager","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2009.02.041_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0006-3223(93)90004-W","article-title":"Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study","volume":"33","author":"De Cristofaro","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib10","first-page":"135","article-title":"Evaluation of regional cerebral blood flow changes in panic disorder with Tc99m-HMPAO SPECT","volume":"123","author":"Eren","year":"2003","journal-title":"Psych. Res."},{"key":"10.1016\/j.neulet.2009.02.041_bib11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1176\/ajp.2006.163.4.710","article-title":"Brain pH Response to hyperventilation in panic disorder: preliminary evidence for altered acid\u2013base regulation","volume":"163","author":"Friedman","year":"2006","journal-title":"Am. J. Psych."},{"key":"10.1016\/j.neulet.2009.02.041_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresprot.2005.06.002","article-title":"Oxidation of 14C-labeled substrates by hippocampal slice cultures","volume":"15","author":"Gilbert","year":"2005","journal-title":"Brain Res. Prot."},{"key":"10.1016\/j.neulet.2009.02.041_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.brainres.2006.07.107","article-title":"Elevated lactate suppresses neuronal firing in vivo and inhibits glucose metabolism in hippocampal slice cultures","volume":"1117","author":"Gilbert","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2009.02.041_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism: a new paradigm for the third millennium","volume":"558","author":"Gladden","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2009.02.041_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/archpsyc.1988.01800250035006","article-title":"Ventilatory physiology of patients with panic disorder","volume":"45","author":"Gorman","year":"1988","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0022-3999(98)00027-0","article-title":"Experimental pathophysiology of panic","volume":"45","author":"Griez","year":"1998","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.neulet.2009.02.041_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1176\/foc.2.3.402","article-title":"Neurocircuitry of anxiety disorders","volume":"2","author":"Kent","year":"2004","journal-title":"Focus"},{"key":"10.1016\/j.neulet.2009.02.041_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1096-9861(20000403)419:2<205::AID-CNE5>3.0.CO;2-0","article-title":"Topographical organization of projections from the subiculum to the hypothalamus in the rat","volume":"419","author":"Kishi","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2009.02.041_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archpsyc.1985.01790300077010","article-title":"Lactate provocation of panic attacks. II. Biochemical and physiological findings","volume":"42","author":"Liebowitz","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-0447.1985.tb02596.x","article-title":"Lactate-induced panic attacks: possible involvement of serotonin reuptake stimulation","volume":"72","author":"Lingjaerde","year":"1985","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.neulet.2009.02.041_bib21","doi-asserted-by":"crossref","DOI":"10.1176\/jnp.13.1.22","article-title":"The lactic acid response to alkalosis in panic disorder: an integrative review","volume":"13","author":"Maddock","year":"2001","journal-title":"J. Neuropsych. Clin. Neurosci."},{"key":"10.1016\/j.neulet.2009.02.041_bib22","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1242\/jeb.02208","article-title":"Neuron\u2013glia metabolic coupling and plasticity","volume":"209","author":"Magistretti","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.neulet.2009.02.041_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0893-133X(02)00296-8","article-title":"Respiratory responses to intravenous infusion of sodium lactate in male and female Wistar rats","volume":"27","author":"Olsson","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2009.02.041_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1523\/JNEUROSCI.2064-05.2006","article-title":"Cognitive disorganization in hippocampus: a physiological model of the disorganization in psychosis","volume":"26","author":"Olypher","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.02.041_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/anxi.3070010204","article-title":"Lactate-induced anxiety after imipramine and diazepam treatment","volume":"1","author":"Pohl","year":"1994","journal-title":"Anxiety"},{"key":"10.1016\/j.neulet.2009.02.041_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0014-4886(73)90290-2","article-title":"Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires","volume":"41","author":"Ranck","year":"1973","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2009.02.041_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/310683a0","article-title":"A focal brain abnormality in panic disorder, a severe form of anxiety","volume":"310","author":"Reiman","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2009.02.041_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/archpsyc.1989.01810060013003","article-title":"Neuroanatomical correlates of a lactate-induced anxiety attack","volume":"46","author":"Reiman","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1176\/ajp.138.5.676","article-title":"Blockage by imipramine or desipramine of panic induced by sodium lactate","volume":"138","author":"Rifkin","year":"1981","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib30","first-page":"927","article-title":"Cerebral glucose metabolism associated with a fear network in panic disorder","volume":"16","author":"Sakai","year":"2005","journal-title":"Neuro Report"},{"key":"10.1016\/j.neulet.2009.02.041_bib31","first-page":"748","article-title":"Effects of treatment with imipramine and clonazepam on an animal model of panic disorder","volume":"36","author":"Shekhar","year":"1994","journal-title":"Biol. Psych."},{"key":"10.1016\/j.neulet.2009.02.041_bib32","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1523\/JNEUROSCI.17-24-09726.1997","article-title":"The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder","volume":"17","author":"Shekhar","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.02.041_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0091-3057(96)00077-9","article-title":"Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions","volume":"55","author":"Shekhar","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2009.02.041_bib34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1749-6632.2003.tb07090.x","article-title":"The amygdala, panic disorder, and cardiovascular responses","volume":"985","author":"Shekhar","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2009.02.041_bib35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/01.WCB.0000063991.19746.11","article-title":"Lactae: a preferred fuel for human brain metabolism in vivo","volume":"23","author":"Smith","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2009.02.041_bib36","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1471-4159.1977.tb10649.x","article-title":"The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat","volume":"28","author":"Sokoloff","year":"1977","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2009.02.041_bib37","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1176\/ajp.145.4.442","article-title":"Cerebral blood flow changes during sodium-lactate-induced panic attacks","volume":"145","author":"Stewart","year":"1988","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2009.02.041_bib38","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1176\/ajp.146.8.1044","article-title":"Imipramine and alprazolam treatment of lactate-induced acute endogenous distress in nonhuman primates","volume":"146","author":"Sunderland","year":"1989","journal-title":"Am. J. Psych."},{"key":"10.1016\/j.neulet.2009.02.041_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ab.2004.10.020","article-title":"Determination of oxidized and reduced nicotinamide dinucleotide in cell monolayers using a single extraction and a spectrophotometric assay","volume":"338","author":"Umemura","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neulet.2009.02.041_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0893-133X(94)00082-B","article-title":"Sodium lactate elicits a rapid increase in blood pressure in Wistar rats and spontaneously hypertensive rats. Effect of pretreatment with the antipanic drugs clomipramine and alprazolam","volume":"12","author":"Wikander","year":"1995","journal-title":"Neuropsychopharmacology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394009002195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394009002195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T03:04:59Z","timestamp":1558148699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394009002195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0304394009002195"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2009.02.041","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}