{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:09:54Z","timestamp":1780499394856,"version":"3.54.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.neulet.2009.05.074","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T04:42:27Z","timestamp":1244522547000},"page":"205-208","source":"Crossref","is-referenced-by-count":38,"title":["Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration"],"prefix":"10.1016","volume":"460","author":[{"given":"Simon","family":"Paine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Bedford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R.","family":"Thorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nin","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Layfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2009.05.074_bib1","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.05.074_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.2005.03181.x","article-title":"Sequestosome 1\/p62 shuttles polyubiquitinated tau for proteasomal degradation","volume":"94","author":"Babu","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2009.05.074_bib3","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1523\/JNEUROSCI.2218-08.2008","article-title":"Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies","volume":"28","author":"Bedford","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.05.074_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","article-title":"Global changes to the ubiquitin system in Huntington's disease","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2009.05.074_bib5","doi-asserted-by":"crossref","first-page":"10825","DOI":"10.1074\/jbc.M512786200","article-title":"Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation","volume":"281","author":"Cripps","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.05.074_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular pathways of neurodegeneration in Parkinson's disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neulet.2009.05.074_bib7","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1128\/MCB.14.8.5501","article-title":"Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant","volume":"14","author":"Finley","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neulet.2009.05.074_bib8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/embor.2008.93","article-title":"Atypical ubiquitin chains: new molecular signals","volume":"9","author":"Ikeda","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neulet.2009.05.074_bib9","doi-asserted-by":"crossref","first-page":"17375","DOI":"10.1074\/jbc.M609659200","article-title":"Certain pairs of ubiquitin-conjugating enzymes (E2 s) and ubiquitin-protein ligases (E3 s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages","volume":"282","author":"Kim","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.05.074_bib10","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.1073\/pnas.170173897","article-title":"Inhibition of the ubiquitin-proteasome system in Alzheimer's disease","volume":"97","author":"Lam","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2009.05.074_bib11","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1523\/JNEUROSCI.4474-04.2005","article-title":"Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation","volume":"25","author":"Lim","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2009.05.074_bib12","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1074\/jbc.M700422200","article-title":"Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis","volume":"282","author":"Liu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2009.05.074_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/path.1711550105","volume":"155","author":"Lowe","year":"1988","journal-title":"J. Pathol."},{"key":"10.1016\/j.neulet.2009.05.074_bib14","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1073\/pnas.85.12.4501","article-title":"Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases","volume":"85","author":"Manetto","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2009.05.074_bib15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/0896-6273(93)90063-W","article-title":"Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments","volume":"10","author":"Morishima-Kawashima","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2009.05.074_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/emboj.2008.305","article-title":"Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome","volume":"28","author":"Saeki","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.neulet.2009.05.074_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/hmg\/ddm320","article-title":"Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases","volume":"17","author":"Tan","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2009.05.074_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nbd.2004.07.008","article-title":"Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias","volume":"17","author":"Thorpe","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2009.05.074_bib19","doi-asserted-by":"crossref","first-page":"20197","DOI":"10.1073\/pnas.0810461105","article-title":"Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for lysine 63-linked polyubiquitin","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439400900737X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439400900737X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T23:25:42Z","timestamp":1545175542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439400900737X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S030439400900737X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2009.05.074","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}