{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:23:40Z","timestamp":1789953820254,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.neulet.2010.05.039","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T04:45:44Z","timestamp":1274417144000},"page":"112-117","source":"Crossref","is-referenced-by-count":46,"title":["Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats"],"prefix":"10.1016","volume":"479","author":[{"given":"Ricardo","family":"Llorente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"O'Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dolores","family":"Gutierrez-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Llorente-Berzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Colado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Paz","family":"Viveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2010.05.039_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0074-7742(06)78005-9","article-title":"Alterations of serotonin transmission in schizophrenia","volume":"78","author":"Abi-Dargham","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neulet.2010.05.039_bib2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00008877-200409000-00005","article-title":"Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model","volume":"15","author":"Adriani","year":"2004","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neulet.2010.05.039_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.neuroscience.2006.12.007","article-title":"Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats","volume":"145","author":"Arborelius","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2010.05.039_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00172108","article-title":"In vivo evidence for a greater brain tryptophan hydroxylase capacity in female than in male rats","volume":"338","author":"Carlsson","year":"1988","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.neulet.2010.05.039_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neubiorev.2008.09.001","article-title":"Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates","volume":"33","author":"Cirulli","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2010.05.039_bib6","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1111\/j.1471-4159.1972.tb01486.x","article-title":"Effects of immobilization and food deprivation on rat brain tryptophan metabolism","volume":"19","author":"Curzon","year":"1972","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2010.05.039_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1749-6632.2008.03979.x","article-title":"Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions","volume":"1153","author":"De la Fuente","year":"2009","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.neulet.2010.05.039_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pnpbp.2008.11.012","article-title":"Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling","volume":"33","author":"Duchesne","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2010.05.039_bib9","first-page":"27","article-title":"Maternal separation reduces latent inhibition in the conditioned taste aversion paradigm","volume":"17","author":"Ellenbroek","year":"1995","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/j.neulet.2010.05.039_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1566-2772(03)00090-2","article-title":"Early maternal deprivation as an animal model for schizophrenia","volume":"3","author":"Ellenbroek","year":"2003","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.neulet.2010.05.039_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0920-9964(97)00149-7","article-title":"The effects of an early stressful life event on sensorimotor gating in adult rats","volume":"30","author":"Ellenbroek","year":"1998","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neulet.2010.05.039_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pbb.2008.12.013","article-title":"Neurobiology of the development of motivated behaviors in adolescence: a window into a neural systems model","volume":"93","author":"Ernst","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2010.05.039_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2007.12.033","article-title":"Maternal separation during a specific postnatal time window prevents reinforcement of hippocampal long-term potentiation in adolescent rats","volume":"152","author":"Gruss","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2010.05.039_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(06)78001-1","article-title":"Neurobiology of dopamine in schizophrenia","volume":"78","author":"Guillin","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neulet.2010.05.039_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2005.09.064","article-title":"Mechanisms differentiating normal from abnormal aggression: glucocorticoids and serotonin","volume":"526","author":"Haller","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2010.05.039_bib16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1017\/S0033291702006219","article-title":"Childhood parental loss and risk for first-onset of major depression and alcohol dependence: the time-decay of risk and sex differences","volume":"32","author":"Kendler","year":"2002","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neulet.2010.05.039_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neures.2007.01.008","article-title":"Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation","volume":"58","author":"Lee","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neulet.2010.05.039_bib18","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.psyneuen.2007.04.002","article-title":"Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats","volume":"32","author":"Llorente","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2010.05.039_bib19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neubiorev.2008.03.008","article-title":"Detrimental psychophysiological effects of early maternal deprivation in adolescent and adult rodents: altered responses to cannabinoid exposure","volume":"33","author":"Marco","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2010.05.039_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1590\/S0004-282X2001000400004","article-title":"Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition","volume":"59","author":"Medeiros","year":"2001","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.neulet.2010.05.039_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1017\/S0033291706009330","article-title":"Parental separation, loss and psychosis in different ethnic groups: a case\u2013control study","volume":"37","author":"Morgan","year":"2007","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neulet.2010.05.039_bib22","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1373\/clinchem.2009.123752","article-title":"The role of serotonin in the pathophysiology of depression: as important as ever","volume":"55","author":"Nemeroff","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neulet.2010.05.039_bib23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1365-2982.2007.01065.x","article-title":"Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model","volume":"20","author":"O\u2019Mahony","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"issue":"Suppl.","key":"10.1016\/j.neulet.2010.05.039_bib24","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.brainres.2009.08.069","article-title":"Two repeated maternal separation procedures differentially affect brain 5-hydroxytryptamine transporter and receptors in young and adult male and female rats","volume":"1305","author":"Oreland","year":"2009","journal-title":"Brain. Res."},{"key":"10.1016\/j.neulet.2010.05.039_bib25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.yhbeh.2009.03.010","article-title":"Back to the future: the organizational\u2013activational hypothesis adapted to puberty and adolescence","volume":"55","author":"Schulz","year":"2009","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neulet.2010.05.039_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1196\/annals.1308.002","article-title":"Adolescent brain development and animal models","volume":"1021","author":"Spear","year":"2004","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.neulet.2010.05.039_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S1092852900016837","article-title":"Depression, anhedonia, and psychomotor symptoms: the role of dopaminergic neurocircuitry","volume":"13","author":"Stein","year":"2008","journal-title":"CNS Spectrosc."},{"key":"10.1016\/j.neulet.2010.05.039_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000122379","article-title":"Effect of adrenocortical hormones on activity of the serotoninergic system in limbic structures in rats","volume":"18","author":"Telegdy","year":"1975","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2010.05.039_bib29","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1210\/endo-108-4-1392","article-title":"Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods","volume":"108","author":"Van Loon","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2010.05.039_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2009.05.015","article-title":"Sex-dependent alterations in response to maternal deprivation in rats","author":"Viveros","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2010.05.039_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbr.2008.07.039","article-title":"Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia","volume":"196","author":"Lam","year":"2009","journal-title":"Behav. Brain Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394010006245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394010006245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T20:52:04Z","timestamp":1544475124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394010006245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0304394010006245"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2010.05.039","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}