{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:30:46Z","timestamp":1772764246089,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.neulet.2010.07.004","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T23:54:56Z","timestamp":1278892496000},"page":"51-56","source":"Crossref","is-referenced-by-count":37,"title":["The role of p38 MAPK in valproic acid induced microglia apoptosis"],"prefix":"10.1016","volume":"482","author":[{"given":"Nanchang","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2010.07.004_bib0005","doi-asserted-by":"crossref","first-page":"30476","DOI":"10.1074\/jbc.M705783200","article-title":"MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta","volume":"282","author":"Abell","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2010.07.004_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2010.07.004_bib0015","doi-asserted-by":"crossref","first-page":"33195","DOI":"10.1074\/jbc.M109.020586","article-title":"Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis","volume":"284","author":"Chang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2010.07.004_bib0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2007.06.053","article-title":"Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity","volume":"149","author":"Chen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2010.07.004_bib0025","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.neuroscience.2006.02.065","article-title":"Valproic acid induces caspase 3-mediated apoptosis in microglial cells","volume":"140","author":"Dragunow","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2010.07.004_bib0030","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1124\/mol.106.030718","article-title":"Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate","volume":"71","author":"Gomez-Lazaro","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2010.07.004_bib0035","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neulet.2010.07.004_bib0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuint.2007.03.005","article-title":"Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580","volume":"51","author":"Hamanoue","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2010.07.004_bib0045","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","volume":"24","author":"Hao","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2010.07.004_bib0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1096\/fj.03-0295com","article-title":"Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades","volume":"18","author":"Jayanthi","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2010.07.004_bib0055","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action","volume":"321","author":"Kim","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2010.07.004_bib0060","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1471-4159.2004.02725.x","article-title":"The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells","volume":"91","author":"Laeng","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2010.07.004_bib0065","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0006-8993(00)03257-1","article-title":"NO as an autocrine mediator in the apoptosis of activated microglial cells: correlation between activation and apoptosis of microglial cells","volume":"892","author":"Lee","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2010.07.004_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-59745-339-4_2","article-title":"Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis","volume":"414","author":"Mazumder","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neulet.2010.07.004_bib0075","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.4161\/cc.6.17.4610","article-title":"By blocking apoptosis, Bcl-2 in p38-dependent manner promotes cell cycle arrest and accelerated senescence after DNA damage and serum withdrawal","volume":"6","author":"Nelyudova","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neulet.2010.07.004_bib0080","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neulet.2010.07.004_bib0085","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1091\/mbc.E03-08-0592","article-title":"P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli","volume":"15","author":"Porras","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neulet.2010.07.004_bib0090","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1096\/fj.09-134700","article-title":"Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury","volume":"23","author":"Shein","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2010.07.004_bib0095","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.4049\/jimmunol.168.8.4025","article-title":"Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis","volume":"168","author":"Singhal","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.neulet.2010.07.004_bib0100","first-page":"347","article-title":"Actions of sodium valproate on the central nervous system","volume":"50","author":"Tunnicliff","year":"1999","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.neulet.2010.07.004_bib0105","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuint.2007.10.006","article-title":"Programmed cell death and differential JNK, p38 and ERK response in a prenatal acute hypoxic hypoxia model","volume":"52","author":"Vacotto","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2010.07.004_bib0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ajh.10161","article-title":"Induction of fetal hemoglobin synthesis by valproate: modulation of MAP kinase pathways","volume":"71","author":"Witt","year":"2002","journal-title":"Am. J. Hematol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394010008931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394010008931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T17:28:22Z","timestamp":1544376502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394010008931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0304394010008931"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2010.07.004","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}