{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:02Z","timestamp":1788871682535,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2006DKA21300"],"award-info":[{"award-number":["2006DKA21300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2007CB511905"],"award-info":[{"award-number":["2007CB511905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.neulet.2011.03.060","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T21:33:15Z","timestamp":1301693595000},"page":"155-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of IL8 \u2212251A\/T, IL12B \u22121188A\/C and TNF-\u03b1 \u2212238A\/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population"],"prefix":"10.1016","volume":"495","author":[{"given":"Shiguo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingji","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2011.03.060_bib0005","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.canep.2009.06.001","article-title":"G-308A TNF-alpha polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: case\u2013control study","volume":"33","author":"Akkiz","year":"2009","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0010","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.braindev.2008.10.003","article-title":"The Rorschach test and Gilles de la Tourette's syndrome: a pilot case\u2013control study","volume":"31","author":"Balottin","year":"2009","journal-title":"Brain Dev."},{"key":"10.1016\/j.neulet.2011.03.060_bib0015","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.iy.07.040189.003205","article-title":"The biology of cachectin\/TNF\u2014a primary mediator of the host response","volume":"7","author":"Beutler","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0020","first-page":"32","article-title":"Relevance of the tumor necrosis factor alpha (TNF alpha) \u2212308 promoter polymorphism in TNF alpha gene regulation","volume":"46","author":"Brinkman","year":"1995","journal-title":"J. Inflamm."},{"key":"10.1016\/j.neulet.2011.03.060_bib0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1067\/mpd.2001.110325","article-title":"Group A streptococcal infections and tic disorders in an Italian pediatric population","volume":"138","author":"Cardona","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.neulet.2011.03.060_bib0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pediatrneurol.2010.01.006","article-title":"Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome","volume":"42","author":"Chou","year":"2010","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0035","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/adc.2003.031880","article-title":"Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders?","volume":"89","author":"Church","year":"2004","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.neulet.2011.03.060_bib0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/01.ypg.0000107927.32051.f5","article-title":"Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13","volume":"14","author":"Curtis","year":"2004","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neulet.2011.03.060_bib0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2005.10.014","article-title":"Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease","volume":"172","author":"Dale","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00218279","article-title":"An interleukin-8 (IL-8) cDNA clone identifies a frequent HindIII polymorphism","volume":"91","author":"Fey","year":"1993","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neulet.2011.03.060_bib0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cca.2006.08.023","article-title":"Variation of interleukin 8\u2013251 A>T polymorphism in worldwide populations and intra-ethnic differences in Japanese populations","volume":"377","author":"Fujihara","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neulet.2011.03.060_bib0060","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.pnpbp.2009.05.001","article-title":"A cytokine study in children and adolescents with Tourette's disorder","volume":"33","author":"Gabbay","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.16.1.495","article-title":"The interleukin-12\/interleukin-12-receptor system: role in normal and pathologic immune responses","volume":"16","author":"Gately","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0070","doi-asserted-by":"crossref","unstructured":"Tourette Syndrome Association International Consortium for Genetics, Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families, Am. J. Hum. Genet. 80 (2007) 265\u2013272.","DOI":"10.1086\/511052"},{"key":"10.1016\/j.neulet.2011.03.060_bib0075","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/bjo.2007.123190","article-title":"Interleukin-8 promoter polymorphism \u2212251A\/T is a risk factor for age-related macular degeneration","volume":"92","author":"Goverdhan","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0080","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1212\/WNL.42.3.652","article-title":"Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins","volume":"42","author":"Hyde","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2011.03.060_bib0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jneuroim.2006.08.007","article-title":"Identification of pyruvate kinase as an antigen associated with Tourette syndrome","volume":"181","author":"Kansy","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0090","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biopsych.2006.06.012","article-title":"Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with Tourette syndrome: a preliminary study","volume":"61","author":"Kawikova","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0095","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1001\/archpsyc.1980.01780250022001","article-title":"Familial pattern of Gilles de la Tourette syndrome","volume":"37","author":"Kidd","year":"1980","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0100","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm892","article-title":"Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea","volume":"9","author":"Kirvan","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2011.03.060_bib0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jneuroim.2006.06.017","article-title":"Antibody-mediated neuronal cell signaling in behavior and movement disorders","volume":"179","author":"Kirvan","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(88)90486-2","article-title":"A novel form of TNF\/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF","volume":"53","author":"Kriegler","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2011.03.060_bib0115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0161-5890(97)00052-7","article-title":"The \u2212308 tumor necrosis factor-alpha promoter polymorphism effects transcription","volume":"34","author":"Kroeger","year":"1997","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0120","first-page":"1","article-title":"Phenomenology of tics and natural history of tic disorders","volume":"99","author":"Leckman","year":"2006","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0125","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2004.12.004","article-title":"Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome","volume":"57","author":"Leckman","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0130","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/clim.1998.4680","article-title":"Exogenous IL-10 and IL-4 down-regulate IL-6 production by SLE-derived PBMC","volume":"91","author":"Linker-Israeli","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0135","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ajmg.b.30550","article-title":"A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report","volume":"144B","author":"Lit","year":"2007","journal-title":"Am. J. Med. Genet. B: Neuropsychiatr. Genet."},{"key":"10.1016\/j.neulet.2011.03.060_bib0140","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.4049\/jimmunol.143.12.4034","article-title":"Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor","volume":"143","author":"Luettig","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1590\/S1413-86702009000400002","article-title":"The NRAMPI, VDR and TNF-alpha gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility","volume":"13","author":"Merza","year":"2009","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.neulet.2011.03.060_bib0150","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/84872","article-title":"Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele","volume":"27","author":"Morahan","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2011.03.060_bib0155","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.bbi.2010.02.007","article-title":"Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases","volume":"24","author":"Morer","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2011.03.060_bib0160","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11920-001-0013-2","article-title":"The genetics of Tourette syndrome","volume":"3","author":"Pauls","year":"2001","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neulet.2011.03.060_bib0165","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/312724a0","article-title":"Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin","volume":"312","author":"Pennica","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2011.03.060_bib0170","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/archpsyc.1985.01790310077011","article-title":"A twin study of Tourette syndrome","volume":"42","author":"Price","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0175","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jpsychores.2008.03.006","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: The epidemiological and prevalence studies","volume":"65","author":"Robertson","year":"2008","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.neulet.2011.03.060_bib0180","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaut.2005.05.005","article-title":"TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production","volume":"25","author":"Sallakci","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.neulet.2011.03.060_bib0185","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/sj.gene.6363919","article-title":"A TaqI polymorphism in the 3\u2032UTR of the IL-12 p40 gene correlates with increased IL-12 secretion","volume":"3","author":"Seegers","year":"2002","journal-title":"Genes Immun."},{"key":"10.1016\/j.neulet.2011.03.060_bib0195","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1086\/302613","article-title":"A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome","volume":"65","author":"The Tourette Syndrome Association International Consortium for Genetics","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neulet.2011.03.060_bib0200","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.arcmed.2010.02.002","article-title":"TNF polymorphisms in patients with Behcet disease: a meta-analysis","volume":"41","author":"Touma","year":"2010","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.neulet.2011.03.060_bib0205","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1399-0039.1998.tb03056.x","article-title":"Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter","volume":"52","author":"Uglialoro","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.neulet.2011.03.060_bib0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ana.1107","article-title":"Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis","volume":"50","author":"van Veen","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2011.03.060_bib0215","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/0006-3223(95)00520-X","article-title":"Cytokine production in obsessive\u2013compulsive disorder","volume":"40","author":"Weizman","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2011.03.060_bib0220","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1086\/339520","article-title":"Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome","volume":"70","author":"Zhang","year":"2002","journal-title":"Am. J. Hum. Genet."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394011003648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394011003648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T13:12:51Z","timestamp":1740575571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394011003648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0304394011003648"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2011.03.060","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of IL8 \u2212251A\/T, IL12B \u22121188A\/C and TNF-\u03b1 \u2212238A\/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2011.03.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2011 Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}