{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:37:33Z","timestamp":1786934253686,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL-047600"],"award-info":[{"award-number":["HL-047600"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.neulet.2011.10.015","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T14:56:46Z","timestamp":1318863406000},"page":"176-179","source":"Crossref","is-referenced-by-count":19,"title":["Rats subjected to chronic-intermittent hypoxia have increased density of noradrenergic terminals in the trigeminal sensory and motor nuclei"],"prefix":"10.1016","volume":"505","author":[{"given":"Pari","family":"Mody","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Rukhadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Kubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2011.10.015_bib0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0361-9230(88)90245-6","article-title":"Catecholamine innervation of the rat hypoglossal nucleus","volume":"21","author":"Aldes","year":"1988","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2011.10.015_bib0010","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1164\/rccm.200605-597OC","article-title":"Endogenous excitatory drive modulating respiratory muscle activity across sleep\u2013wake states","volume":"174","author":"Chan","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/ilar.50.3.262","article-title":"Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease","volume":"50","author":"Dematteis","year":"2009","journal-title":"ILAR J."},{"key":"10.1016\/j.neulet.2011.10.015_bib0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"Dempsey","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2011.10.015_bib0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00424-002-0797-x","article-title":"Influence of nasotrigeminal afferents on medullary respiratory neurones and upper airway patency in the rat","volume":"444","author":"Dutschmann","year":"2002","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.neulet.2011.10.015_bib0030","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1164\/rccm.200412-1750OC","article-title":"REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs","volume":"172","author":"Fenik","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0034-5687(99)00114-0","article-title":"Effect of episodic hypoxia on sympathetic activity and blood pressure","volume":"119","author":"Fletcher","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.neulet.2011.10.015_bib0040","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1523\/JNEUROSCI.4274-09.2010","article-title":"Corticofugal control of vibrissa-sensitive neurons in the interpolaris nucleus of the trigeminal complex","volume":"30","author":"Furuta","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2011.10.015_bib0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cne.902630107","article-title":"Noradrenergic projections to brainstem nuclei: evidence for differential projections from noradrenergic subgroups","volume":"263","author":"Grzanna","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2011.10.015_bib0050","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200610-1527OC","article-title":"Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity","volume":"175","author":"Iiyori","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.1987.sp016816","article-title":"A convergent input from nasal receptors and the larynx to the rostral sensory trigeminal nuclei of the cat","volume":"393","author":"Jordan","year":"1987","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.neulet.2011.10.015_bib0060","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.archoralbio.2009.08.008","article-title":"Role of the spinal trigeminal nucleus in the rat autonomic reflex","volume":"54","author":"Koeda","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.neulet.2011.10.015_bib0065","series-title":"Sleep Apnea. Pathogenesis, Diagnosis, and Treatment","first-page":"99","article-title":"Mechanisms of airway hypotonia","author":"Kubin","year":"2002"},{"key":"10.1016\/j.neulet.2011.10.015_bib0070","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI115751","article-title":"Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism)","volume":"89","author":"Mezzanotte","year":"1992","journal-title":"J. Clin. Invest."},{"issue":"Suppl.","key":"10.1016\/j.neulet.2011.10.015_bib0075","first-page":"A32","article-title":"Rats subjected to chronic-intermittent hypoxia (CIH) have increased density of noradrenergic terminals in the trigeminal sensory (Sp5) and motor (Mo5) nuclei","volume":"34","author":"Mody","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.neulet.2011.10.015_bib0080","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1523\/JNEUROSCI.2803-06.2007","article-title":"Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability","volume":"27","author":"Neverova","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2011.10.015_bib0085","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-8993(00)02549-X","article-title":"Trigemino-autonomic connections in the muskrat: the neural substrate for the diving response","volume":"874","author":"Panneton","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2011.10.015_bib0090","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.neulet.2011.10.015_bib0095","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0100","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/jappl.1978.44.6.931","article-title":"Pathogenesis of upper airway occlusion during sleep","volume":"44","author":"Remmers","year":"1978","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2011.10.015_bib0105","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1164\/rccm.200912-1884OC","article-title":"Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus","volume":"182","author":"Rukhadze","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jchemneu.2006.10.001","article-title":"Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract","volume":"33","author":"Rukhadze","year":"2007","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neulet.2011.10.015_bib0115","first-page":"1144","article-title":"Effect of electrical stimulation of the hypoglossal nerve on airflow mechanics in the isolated upper airway","volume":"147","author":"Schwartz","year":"1993","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neulet.2011.10.015_bib0120","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1113\/jphysiol.2008.159392","article-title":"Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats","volume":"586","author":"Schwarz","year":"2008","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.neulet.2011.10.015_bib0125","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1172\/JCI118235","article-title":"Sympathetic neural mechanisms in obstructive sleep apnea","volume":"96","author":"Somers","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2011.10.015_bib0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1164\/ajrccm\/137.4.889","article-title":"Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects","volume":"137","author":"Suratt","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.neulet.2011.10.015_bib0135","doi-asserted-by":"crossref","first-page":"16886","DOI":"10.1523\/JNEUROSCI.3394-10.2010","article-title":"Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback","volume":"30","author":"Tadjalli","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2011.10.015_bib0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/expphysiol.2006.035733","article-title":"Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension","volume":"92","author":"Weiss","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neulet.2011.10.015_bib0145","doi-asserted-by":"crossref","first-page":"10060","DOI":"10.1523\/JNEUROSCI.0857-07.2007","article-title":"Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model","volume":"27","author":"Zhu","year":"2007","journal-title":"J. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394011014017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394011014017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T15:51:29Z","timestamp":1560786689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394011014017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0304394011014017"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2011.10.015","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}