{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:53:20Z","timestamp":1774882400906,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.neulet.2012.08.042","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T16:39:17Z","timestamp":1346344757000},"page":"100-104","source":"Crossref","is-referenced-by-count":15,"title":["Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals"],"prefix":"10.1016","volume":"527","author":[{"given":"Cecilie","family":"Morland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaja","family":"Nordengen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidar","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2012.08.042_bib0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00964170","article-title":"Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities","volume":"9","author":"Battistin","year":"1984","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nprot.2007.525","article-title":"Immunogold quantification of amino acids and proteins in complex subcellular compartments","volume":"3","author":"Bergersen","year":"2008","journal-title":"Nature Protocols"},{"key":"10.1016\/j.neulet.2012.08.042_bib0015","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0006-8993(92)91038-G","article-title":"The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study","volume":"594","author":"Biggs","year":"1992","journal-title":"Brain Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0020","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1460-9568.1993.tb00958.x","article-title":"Enrichment of glutamate-like immunoreactivity in primary afferent terminals throughout the spinal cord dorsal horn","volume":"5","author":"Broman","year":"1993","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.neulet.2012.08.042_bib0025","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/BF00964888","article-title":"Acute effects of sodium valproate and gamma-vinyl GABA on regional amino acid metabolism in the rat brain: incorporation of 2-[14C]glucose into amino acids","volume":"7","author":"Chapman","year":"1982","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0030","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1528-1157.1987.tb03661.x","article-title":"Common anticonvulsants inhibit Ca2+ uptake and amino acid neurotransmitter release in vitro","volume":"28","author":"Crowder","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/j.neulet.2012.08.042_bib0035","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0028-3908(03)00270-3","article-title":"Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro","volume":"45","author":"Cunningham","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0040","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0026-895X(25)08949-7","article-title":"Selectivity of amino acid transmitters acting at N-methyl-d-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors","volume":"41","author":"Curras","year":"1992","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00213-006-0317-3","article-title":"Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex","volume":"185","author":"Gobbi","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0050","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1471-4159.1969.tb08975.x","article-title":"Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism","volume":"16","author":"Godin","year":"1969","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neulet.2012.08.042_bib0055","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1523\/JNEUROSCI.18-16-06059.1998","article-title":"Synaptic vesicular localization and exocytosis of l-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus","volume":"18","author":"Gundersen","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.neulet.2012.08.042_bib0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00004647-200101000-00006","article-title":"Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study","volume":"21","author":"Gundersen","year":"2001","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.neulet.2012.08.042_bib0065","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mcn.2004.01.017","article-title":"GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission","volume":"26","author":"Gundersen","year":"2004","journal-title":"Molecular and Cellular Neurosciences"},{"key":"10.1016\/j.neulet.2012.08.042_bib0070","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00004647-199711000-00012","article-title":"Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate","volume":"17","author":"Hassel","year":"1997","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.neulet.2012.08.042_bib0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(01)02180-2","article-title":"Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study","volume":"311","author":"He","year":"2001","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neulet.2012.08.042_bib0080","first-page":"541","article-title":"Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it","volume":"46","author":"Hiramatsu","year":"1992","journal-title":"Japanese Journal of Psychiatry and Neurology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0085","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/glia.20672","article-title":"Low-affinity excitatory amino acid uptake in hippocampal astrocytes: a possible role of Na+\/dicarboxylate cotransporters","volume":"56","author":"Holten","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2012.08.042_bib0090","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1471-4159.2007.05065.x","article-title":"Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase","volume":"104","author":"Holten","year":"2008","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neulet.2012.08.042_bib0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-1211(01)00308-4","article-title":"The acute effect of valproate on cerebral energy metabolism in mice","volume":"47","author":"Johannessen","year":"2001","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0100","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1097\/00001756-200112040-00025","article-title":"Estimation of aspartate synthesis in GABAergic neurons in mice by 13C NMR spectroscopy","volume":"12","author":"Johannessen","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2012.08.042_bib0105","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1248\/cpb.25.2257","article-title":"Effects of sodium dipropylacetate on gamma-aminobutyric acid and biogenic amines in rat brain","volume":"25","author":"Kukino","year":"1977","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.neulet.2012.08.042_bib0110","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1471-4159.1977.tb10434.x","article-title":"Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization","volume":"28","author":"Lai","year":"1977","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neulet.2012.08.042_bib0115","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/j.1460-9568.2005.04081.x","article-title":"Different basal levels of CaMKII phosphorylated at Thr286\/287 at nociceptive and low-threshold primary afferent synapses","volume":"21","author":"Larsson","year":"2005","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.neulet.2012.08.042_bib0120","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0197-0186(03)00148-7","article-title":"Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus","volume":"44","author":"Li","year":"2004","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.neulet.2012.08.042_bib0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3940(93)90407-C","article-title":"In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats","volume":"160","author":"Loscher","year":"1993","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neulet.2012.08.042_bib0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action","volume":"58","author":"L\u00f6scher","year":"1999","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0135","first-page":"270","article-title":"Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma","volume":"349","author":"Loscher","year":"1994","journal-title":"Naunyn-Schmiedebergs Archiv fur Pharmakologie"},{"key":"10.1016\/j.neulet.2012.08.042_bib0140","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0304-3940(84)90534-2","article-title":"Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects","volume":"47","author":"Loscher","year":"1984","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neulet.2012.08.042_bib0145","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0006-8993(79)90975-2","article-title":"Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons","volume":"170","author":"Macdonald","year":"1979","journal-title":"Brain Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0150","first-page":"713","article-title":"Anticonvulsant drugs: mechanisms of action","volume":"44","author":"Macdonald","year":"1986","journal-title":"Advances in Neurology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1874467210902010095","article-title":"Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection","volume":"2","author":"Monti","year":"2009","journal-title":"Current Molecular Pharmacology"},{"key":"10.1016\/j.neulet.2012.08.042_bib0160","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/01.WCB.0000138666.25305.A7","article-title":"Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake","volume":"24","author":"Morland","year":"2004","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.neulet.2012.08.042_bib0165","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuint.2007.01.003","article-title":"Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain","volume":"50","author":"Morland","year":"2007","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.neulet.2012.08.042_bib0170","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s11064-010-0291-3","article-title":"Aspartate release and signalling in the hippocampus","volume":"36","author":"Nadler","year":"2011","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00247039","article-title":"Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing","volume":"69","author":"Ottersen","year":"1987","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.neulet.2012.08.042_bib0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0306-4522(92)90141-N","article-title":"Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum","volume":"46","author":"Ottersen","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2012.08.042_bib0185","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s00018-007-7079-x","article-title":"The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?","volume":"64","author":"Rosenberg","year":"2007","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.neulet.2012.08.042_bib0190","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1471-4159.1978.tb06258.x","article-title":"Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity","volume":"31","author":"Schechter","year":"1978","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.neulet.2012.08.042_bib0195","doi-asserted-by":"crossref","first-page":"738","DOI":"10.4088\/JCP.v65n0601","article-title":"Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels","volume":"65","author":"Stahl","year":"2004","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.neulet.2012.08.042_bib0200","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1749-6632.1999.tb11316.x","article-title":"The arrangement of glutamate receptors in excitatory synapses","volume":"868","author":"Takumi","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.neulet.2012.08.042_bib0205","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1523\/JNEUROSCI.3003-04.2005","article-title":"Presynaptic regulation of quantal size by the vesicular glutamate transporter VGLUT1","volume":"25","author":"Wilson","year":"2005","journal-title":"Journal of Neuroscience"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394012011202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394012011202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T15:01:54Z","timestamp":1744038114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394012011202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0304394012011202"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2012.08.042","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}