{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:19:45Z","timestamp":1771269585841,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.neulet.2013.01.025","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T14:16:06Z","timestamp":1359382566000},"page":"15-19","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Presenilin 2 mutation accelerates the onset of impairment in trace eyeblink conditioning in a mouse model of Alzheimer's disease overexpressing human mutant amyloid precursor protein"],"prefix":"10.1016","volume":"538","author":[{"given":"Yasushi","family":"Kishimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kirino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2013.01.025_bib0005","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","article-title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","volume":"19","author":"Borchelt","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2013.01.025_bib0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF01108841","article-title":"Memory deficits in Alzheimer's patients: a comprehensive review","volume":"3","author":"Carlesimo","year":"1992","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neulet.2013.01.025_bib0015","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.neurobiolaging.2005.05.019","article-title":"Associative and motor learning in 12-month-old transgenic APP+PS1 mice","volume":"27","author":"Ewers","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.01.025_bib0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1471-4159.2011.07505.x","article-title":"Assembly of the presenilin \u03b3-\/\u025b-secretase complex","volume":"120","author":"St. George-Hyslop","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2013.01.025_bib0025","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1586\/14737175.8.12.1879","article-title":"Memory loss in Alzheimer's disease: implications for development of therapeutics","volume":"8","author":"Gold","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neulet.2013.01.025_bib0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0197-4580(00)00249-9","article-title":"Correlation between cognitive deficits and A\u03b2 deposits in transgenic APP+PS1 mice","volume":"22","author":"Gordon","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.01.025_bib0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nbd.2008.03.001","article-title":"Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load","volume":"30","author":"Gruart","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2013.01.025_bib0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid \u03b2-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neulet.2013.01.025_bib0045","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1073\/pnas.94.6.2095","article-title":"The Alzheimer family of diseases: many etiologies, one pathogenesis?","volume":"94","author":"Hardy","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.01.025_bib0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","article-title":"Amyloid deposition as the central event in the aetiology of Alzheimer's disease","volume":"12","author":"Hardy","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neulet.2013.01.025_bib0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/35017105","article-title":"Total inactivation of \u03b3-secretase activity in presenilin-deficient embryonic stem cells","volume":"2","author":"Herreman","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2013.01.025_bib0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, A\u03b2 elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neulet.2013.01.025_bib0070","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1074\/jbc.275.5.3173","article-title":"The transmembrane aspartates in presenilin 1 and 2 are obligatory for \u03b3-secretase activity and amyloid \u03b2-protein generation","volume":"275","author":"Kimberly","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2013.01.025_bib0075","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1523\/JNEUROSCI.4142-05.2006","article-title":"Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response","volume":"26","author":"Kishimoto","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neulet.2011.10.071","article-title":"Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease","volume":"506","author":"Kishimoto","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2013.01.025_bib0085","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1097\/00001756-200110290-00040","article-title":"Age-dependent impairment of delay and trace eyeblink conditioning in mice","volume":"12","author":"Kishimoto","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.neulet.2013.01.025_bib0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molmed.2005.02.009","article-title":"Alzheimer's disease: A\u03b2, tau and synaptic dysfunction","volume":"11","author":"LaFerla","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neulet.2013.01.025_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.07.023","article-title":"Early temporal short-term memory deficits in double transgenic APP\/PS1 mice","volume":"33","author":"Lagadec","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.01.025_bib0100","doi-asserted-by":"crossref","first-page":"627.e13","DOI":"10.1016\/j.neurobiolaging.2011.04.005","article-title":"Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence","volume":"33","author":"L\u00f3pez-Ramos","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.01.025_bib0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1037\/0735-7044.104.2.243","article-title":"Hippocampectomy disrupts trace eye-blink conditioning in rabbits","volume":"104","author":"Moyer","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1471-4159.1998.71010313.x","article-title":"Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid \u03b2-protein 42 in the brain","volume":"71","author":"Oyama","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2013.01.025_bib0115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.neuro.21.1.479","article-title":"Mutant genes in familial Alzheimer's disease and transgenic models","volume":"21","author":"Price","year":"1998","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0120","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/nbdi.2002.0481","article-title":"Hippocampal A\u03b2 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice","volume":"9","author":"Puoliv\u00e4li","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2013.01.025_bib0125","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1523\/JNEUROSCI.23-26-08989.2003","article-title":"PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation","volume":"23","author":"Richards","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0130","doi-asserted-by":"crossref","first-page":"27901","DOI":"10.1074\/jbc.M004308200","article-title":"Mutant presenilin 2 transgenic mice. A large increase in the levels of A\u03b2 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin","volume":"275","author":"Sawamura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2013.01.025_bib0135","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.93.24.13438","article-title":"Memory systems in the brain and localization of a memory","volume":"93","author":"Thompson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.01.025_bib0140","doi-asserted-by":"crossref","first-page":"617974","DOI":"10.1155\/2011\/617974","article-title":"Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease","volume":"2011","author":"Toda","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.neulet.2013.01.025_bib0145","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0959-4388(00)00253-1","article-title":"The cell biology of Alzheimer's disease: uncovering the secrets of secretases","volume":"11","author":"Walter","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neulet.2013.01.025_bib0150","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1073\/pnas.1001422107","article-title":"Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.01.025_bib0155","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1006\/nbdi.2002.0555","article-title":"Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice","volume":"11","author":"Weiss","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2013.01.025_bib0160","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1523\/JNEUROSCI.22-05-01858.2002","article-title":"The relationship between A\u03b2 and memory in the Tg2576 mouse model of Alzheimer's disease","volume":"22","author":"Westerman","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2013.01.025_bib0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0197-4580(96)00022-X","article-title":"Alzheimer's disease and eyeblink conditioning: 750ms trace vs. 400ms delay paradigm","volume":"17","author":"Woodruff-Pak","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.01.025_bib0170","series-title":"Eyeblink Classical Conditioning, Volume 1: Applications in Humans","author":"Woodruff-Pak","year":"2000"},{"key":"10.1016\/j.neulet.2013.01.025_bib0175","series-title":"Eyeblink Classical Conditioning, Volume 2: Animal Models","author":"Woodruff-Pak","year":"2000"},{"key":"10.1016\/j.neulet.2013.01.025_bib0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02734044","article-title":"Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease","volume":"36","author":"Woodruff-Pak","year":"2001","journal-title":"Integr. Physiol. Behav. Sci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013000578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013000578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T17:15:18Z","timestamp":1644167718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394013000578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":36,"alternative-id":["S0304394013000578"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2013.01.025","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}