{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:33:43Z","timestamp":1791063223705,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.neulet.2013.06.011","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T07:08:50Z","timestamp":1371452930000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["CYP46A1 intron-2T\/C polymorphism and Alzheimer's disease: An updated meta-analysis of 16 studies including 3960 cases and 3828 controls"],"prefix":"10.1016","volume":"549","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2013.06.011_bib0005","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Bertram","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2013.06.011_bib0010","doi-asserted-by":"crossref","first-page":"30178","DOI":"10.1074\/jbc.272.48.30178","article-title":"Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro","volume":"272","author":"Bjorkhem","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2013.06.011_bib0015","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32188-X","article-title":"Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation","volume":"39","author":"Bjorkhem","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neulet.2013.06.011_bib0020","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neurobiolaging.2003.08.004","article-title":"Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer disease: from risk factors to disease modulators","volume":"25","author":"Borroni","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.06.011_bib0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00001756-200401190-00019","article-title":"APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease","volume":"15","author":"Chalmers","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2013.06.011_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000080025","article-title":"Genetic association of CYP46 and risk for Alzheimer's disease","volume":"18","author":"Combarros","year":"2004","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neulet.2013.06.011_bib0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(02)00443-3","article-title":"Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease","volume":"328","author":"Desai","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2013.06.011_bib0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein Egenotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neulet.2013.06.011_bib0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000090215","article-title":"Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease","volume":"21","author":"Fernandez","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neulet.2013.06.011_bib0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-2009-1055","article-title":"Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes","volume":"17","author":"Golanska","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2013.06.011_bib0060","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1111\/j.1471-4159.1991.tb03469.x","article-title":"Cholesterol from degenerating nerve myelin becomes associated with lipoproteins containing apolipoprotein E","volume":"56","author":"Goodrum","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2013.06.011_bib0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1136\/jnnp.2005.071928","article-title":"Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary","volume":"77","author":"Helisalmi","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2013.06.011_bib0075","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neulet.2004.06.011","article-title":"Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease","volume":"367","author":"Ingelsson","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2013.06.011_bib0080","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(00)03155-X","article-title":"Statins and the risk of dementia","volume":"356","author":"Jick","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2013.06.011_bib0085","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00439-004-1107-9","article-title":"Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease","volume":"114","author":"Johansson","year":"2004","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neulet.2013.06.011_bib0095","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1471-4159.1995.64020895.x","article-title":"Cholesterol for synthesis of myelin is made locally, not imported into brain","volume":"64","author":"Jurevics","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2013.06.011_bib0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neulet.2004.03.066","article-title":"Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population","volume":"363","author":"Kabbara","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2013.06.011_bib0105","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/bmj.322.7300.1447","article-title":"Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study","volume":"322","author":"Kivipelto","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.neulet.2013.06.011_bib0110","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/sj.mp.4001109","article-title":"Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease","volume":"7","author":"K\u01d2lsch","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2013.06.011_bib0115","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJM199207233270406","article-title":"Cumulative meta-analysis of therapeutic trials for myocardial infarction","volume":"327","author":"Lau","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2013.06.011_bib0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1159\/000095723","article-title":"Intron 2 (T\/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients","volume":"22","author":"Li","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neulet.2013.06.011_bib0125","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1093\/hmg\/ddl178","article-title":"DAPK1 variants are associated with Alzheimer's disease and allele-specific expression","volume":"15","author":"Li","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2013.06.011_bib0130","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","article-title":"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasisin the brain","volume":"96","author":"Lund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl.","key":"10.1016\/j.neulet.2013.06.011_bib0135","article-title":"24S-hydroxycholesterol: a marker of brain cholesterol metabolism","volume":"36","author":"Lutjohann","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.neulet.2013.06.011_bib0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S1041610205003108","article-title":"Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population","volume":"18","author":"Ma","year":"2006","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.neulet.2013.06.011_bib0145","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.neulet.2013.06.011_bib0150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000026149","article-title":"Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease","volume":"17","author":"Notkola","year":"1998","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neulet.2013.06.011_bib0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archneur.60.1.29","article-title":"Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism","volume":"60","author":"Papassotiropoulos","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2013.06.011_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(00)00903-1","article-title":"Genetic susceptibility factors for Alzheimer's disease","volume":"412","author":"Richard","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2013.06.011_bib0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000017120","article-title":"Apolipoprotein E genetic variation and Alzheimer's disease. A meta-analysis","volume":"10","author":"Rubinsztein","year":"1999","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neulet.2013.06.011_bib0170","doi-asserted-by":"crossref","first-page":"773.e1","DOI":"10.1016\/j.neurobiolaging.2005.03.029","article-title":"Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease","volume":"27","author":"Tedde","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.06.011_bib0175","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/jmg.2006.048470","article-title":"Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population","volume":"44","author":"Vepsalainen","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neulet.2013.06.011_bib0180","first-page":"114734","article-title":"Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese","author":"Wang","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2013.06.011_bib0185","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2004.07.020","article-title":"Association between a T\/C polymorphism in intron 2 of cholesterol 24S-hydroxylasegene and Alzheimer's disease in Chinese","volume":"369","author":"Wang","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2013.06.011_bib0190","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/archneur.57.10.1439","article-title":"Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors","volume":"57","author":"Wolozin","year":"2000","journal-title":"Arch. Neurol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013005582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013005582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T12:48:57Z","timestamp":1645793337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394013005582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":35,"alternative-id":["S0304394013005582"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2013.06.011","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CYP46A1 intron-2T\/C polymorphism and Alzheimer's disease: An updated meta-analysis of 16 studies including 3960 cases and 3828 controls","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2013.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}