{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:17:40Z","timestamp":1792149460488,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.neulet.2013.07.035","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T12:47:18Z","timestamp":1375274838000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Repeated valproate treatment facilitates fear extinction under specific stimulus conditions"],"prefix":"10.1016","volume":"552","author":[{"given":"Stephen C.","family":"Heinrichs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Leite-Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Rasmusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary B.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2013.07.035_bib0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learning & Memory"},{"key":"10.1016\/j.neulet.2013.07.035_bib0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learning & Memory"},{"key":"10.1016\/j.neulet.2013.07.035_bib0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1037\/0097-7403.29.4.323","article-title":"Temporally massed CS presentations generate more fear extinction than spaced presentations Journal of experimental psychology","volume":"29","author":"Cain","year":"2003","journal-title":"Animal Behavior Processes"},{"key":"10.1016\/j.neulet.2013.07.035_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1024797014210","article-title":"Divalproex in posttraumatic stress disorder: an open-label clinical trial","volume":"12","author":"Clark","year":"1999","journal-title":"Journal of Traumatic Stress"},{"key":"10.1016\/j.neulet.2013.07.035_bib0025","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/JCP.0b013e318160f83b","article-title":"Divalproex in the treatment of posttraumatic stress disorder: a randomized double-blind, placebo-controlled trial in a veteran population,","volume":"28","author":"Davis","year":"2008","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0896-6273(02)01001-2","article-title":"Cellular and systems reconsolidation in the hippocampus","volume":"36","author":"Debiec","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2013.07.035_bib0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuropharm.2009.04.008","article-title":"Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety","volume":"57","author":"Gundersen","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0040","first-page":"89","article-title":"A preliminary controlled trial of divalproex in posttraumatic stress disorder","volume":"21","author":"Hamner","year":"2009","journal-title":"Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists"},{"key":"10.1016\/j.neulet.2013.07.035_bib0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.pbb.2011.01.009","article-title":"The use of cognitive enhancers in animal models of fear extinction","volume":"99","author":"Kaplan","year":"2011","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.neulet.2013.07.035_bib0050","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1037\/0735-7044.121.5.1125","article-title":"Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction","volume":"121","author":"Lattal","year":"2007","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.neulet.2013.07.035_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.beproc.2012.03.008","article-title":"A parametric analysis of factors affecting acquisition and extinction of contextual fear in C57BL\/6 and DBA\/2 mice","volume":"90","author":"Lattal","year":"2012","journal-title":"Behavioural Processes"},{"key":"10.1016\/j.neulet.2013.07.035_bib0060","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pbb.2006.08.015","article-title":"The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder","volume":"85","author":"Li","year":"2006","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.neulet.2013.07.035_bib0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopsych.2009.07.032","article-title":"Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference","volume":"67","author":"Malvaez","year":"2010","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.neulet.2013.07.035_bib0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/FBP.0b013e32833c20c0","article-title":"Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain","volume":"21","author":"Morris","year":"2010","journal-title":"Behavioural Pharmacology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0075","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0896-6273(03)00352-0","article-title":"Protein synthesis subserves reconsolidation or extinction depending on reminder duration","volume":"38","author":"Pedreira","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2013.07.035_bib0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biopsycho.2012.02.005","article-title":"Human fear conditioning and extinction: timing is everything\u2026or is it?","volume":"92","author":"Prenoveau","year":"2013","journal-title":"Biological Psychology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","article-title":"Neural mechanisms of extinction learning and retrieval","volume":"33","author":"Quirk","year":"2008","journal-title":"Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0090","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.conb.2009.05.011","article-title":"Regulation of chromatin structure in memory formation","volume":"19","author":"Roth","year":"2009","journal-title":"Current Opinion in Neurobiology"},{"key":"10.1016\/j.neulet.2013.07.035_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biopsych.2006.06.036","article-title":"Antidepressant-like effects of the histone deacetylase inhibitor sodium butyrate, in the mouse","volume":"62","author":"Schroeder","year":"2007","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.neulet.2013.07.035_bib0100","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jpsychires.2011.01.020","article-title":"d-Cycloserine does not improve but might slightly speed up the outcome of in-vivo exposure therapy in patients with severe agoraphobia and panic disorder in a randomized double blind clinical trial","volume":"45","author":"Siegmund","year":"2011","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.neulet.2013.07.035_bib0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2010.07.080","article-title":"The extinction of morphine-induced conditioned place preference by histone deacetylase inhibition","volume":"483","author":"Wang","year":"2010","journal-title":"Neuroscience Letters"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013006812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013006812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T03:22:27Z","timestamp":1539487347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394013006812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":21,"alternative-id":["S0304394013006812"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2013.07.035","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated valproate treatment facilitates fear extinction under specific stimulus conditions","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2013.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}