{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:16:06Z","timestamp":1791915366671,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81070967"],"award-info":[{"award-number":["81070967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271338"],"award-info":[{"award-number":["81271338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Jiang Su Province","award":["BK2009296"],"award-info":[{"award-number":["BK2009296"]}]},{"name":"Natural Science Foundation of Jiang Su Province","award":["BK20130653"],"award-info":[{"award-number":["BK20130653"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JKZD2013006"],"award-info":[{"award-number":["JKZD2013006"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.neulet.2013.10.052","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T22:07:14Z","timestamp":1383257234000},"page":"90-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"PB","title":["Glimepiride attenuates A\u03b2 production via suppressing BACE1 activity in cortical neurons"],"prefix":"10.1016","volume":"557","author":[{"given":"Feiyang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2013.10.052_bib0005","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1212\/01.wnl.0000262031.18018.1a","article-title":"Blood\u2013brain barrier impairment in Alzheimer disease: stability and functional significance","volume":"68","author":"Bowman","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2013.10.052_bib0010","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1523\/JNEUROSCI.3987-04.2004","article-title":"Peroxisome proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide","volume":"24","author":"Camacho","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2013.10.052_bib0015","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1073\/pnas.0807991106","article-title":"Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.10.052_bib0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1326-2-22","article-title":"The Alzheimer's disease beta-secretase enzyme, BACE1","volume":"2","author":"Cole","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neulet.2013.10.052_bib0025","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1073\/pnas.0809158106","article-title":"Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers","volume":"106","author":"De Felice","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.10.052_bib0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1472-8206.2005.00375.x","article-title":"Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic beta-cell: implications for the treatment of type 2 diabetes","volume":"19","author":"Farret","year":"2005","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2013.10.052_bib0035","doi-asserted-by":"crossref","first-page":"23653","DOI":"10.1074\/jbc.M412113200","article-title":"Sulfonylurea agents exhibit peroxisome proliferator-activated receptor gamma agonistic activity","volume":"280","author":"Fukuen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2013.10.052_bib0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neurobiolaging.2010.02.014","article-title":"Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP\/PS1 mice","volume":"33","author":"Gengler","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.10.052_bib0045","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1046\/j.1471-4159.1998.71051920.x","article-title":"Generation and regulation of beta-amyloid peptide variants by neurons","volume":"71","author":"Gouras","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2013.10.052_bib0050","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2202-9-S3-S5","article-title":"Intranasal delivery bypasses the blood\u2013brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease","volume":"9","author":"Hanson","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neulet.2013.10.052_bib0055","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbrc.2004.12.190","article-title":"Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes","volume":"328","author":"Inukai","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2013.10.052_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archneurol.2007.29","article-title":"Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the cardiovascular health study cognition study","volume":"65","author":"Irie","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2013.10.052_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00023210-200822010-00001","article-title":"The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications","volume":"22","author":"Jiang","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neulet.2013.10.052_bib0070","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/0168-8227(95)01074-N","article-title":"Influence of oral sulfonylurea agents on hepatic glucose uptake","volume":"28","author":"Kawamori","year":"1995","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.neulet.2013.10.052_bib0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2165\/00003495-199855040-00007","article-title":"Glimepiride. A review of its use in the management of type 2 diabetes mellitus","volume":"55","author":"Langtry","year":"1998","journal-title":"Drugs"},{"key":"10.1016\/j.neulet.2013.10.052_bib0080","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4093\/dmj.2011.35.4.340","article-title":"Effects of sulfonylureas on peroxisome proliferator-activated receptor r activity and on glucose uptake by thiazolidinediones","volume":"35","author":"Lee","year":"2011","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.neulet.2013.10.052_bib0085","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3233\/JAD-2010-1314","article-title":"Glp-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease","volume":"19","author":"Li","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2013.10.052_bib0090","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","article-title":"Defects in IGF-1 receptor, insulin receptor and IRS-1\/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling","volume":"31","author":"Moloney","year":"2010","journal-title":"Neurobiol. Aging (Milano)"},{"key":"10.1016\/j.neulet.2013.10.052_bib0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2890509","article-title":"The sulphonylurea drug, glimepiride, stimulates release of glycosylphosphatidylinositol-anchored plasma-membrane proteins from 3T3 adipocytes","volume":"289","author":"M\u00fcller","year":"1993","journal-title":"J. Biochem."},{"key":"10.1016\/j.neulet.2013.10.052_bib0100","series-title":"Annual Reports in Medicinal Chemistry","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-7743(07)42003-6","article-title":"Secretase inhibitors and modulators for the treatment of Alzheimer's disease","author":"Olson","year":"2007"},{"key":"10.1016\/j.neulet.2013.10.052_bib0105","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: the Rotterdam study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2013.10.052_bib0110","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/archneurol.2008.588","article-title":"PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia","volume":"66","author":"Qin","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2013.10.052_bib0115","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1212\/01.WNL.0000265401.62434.36","article-title":"Intranasal insulin improves cognition and modulates beta-amyloid in early AD","volume":"70","author":"Reger","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2013.10.052_bib0120","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2013.10.052_bib0125","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.neurobiolaging.2009.10.009","article-title":"Efficacy of PPAR-\u03b3 agonist pioglitazone in mild Alzheimer disease","volume":"32","author":"Sato","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2013.10.052_bib0130","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1124\/mol.106.024596","article-title":"Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach","volume":"71","author":"Scarsi","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2013.10.052_bib0135","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jnnp.74.1.70","article-title":"Increased blood\u2013brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging","volume":"74","author":"Starr","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2013.10.052_bib0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-2005-7107","article-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease\u2014is this type 3 diabetes?","volume":"7","author":"Steen","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2013.10.052_bib0145","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/jama.280.17.1490","article-title":"Health economic benefits and quality of life during improved glycemic control in patients with type 2 diabetes mellitus: a randomized, controlled, double-blind trial","volume":"280","author":"Testa","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.neulet.2013.10.052_bib0150","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrn2294","article-title":"Glucose neurotoxicity","volume":"9","author":"Tomlinson","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2013.10.052_bib0155","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.3390\/molecules14093589","article-title":"Development of a high-throughput assay for screening of gamma-secretase inhibitor with endogenous human, mouse or Drosophila gamma-secretase","volume":"14","author":"Wang","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.neulet.2013.10.052_bib0160","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.2337\/db10-0539","article-title":"Accelerated progression from mild cognitive impairment to dementia in people with diabetes","volume":"59","author":"Xu","year":"2010","journal-title":"Diabetes"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013009567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013009567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T16:02:01Z","timestamp":1589212921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394013009567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":32,"alternative-id":["S0304394013009567"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2013.10.052","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glimepiride attenuates A\u03b2 production via suppressing BACE1 activity in cortical neurons","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2013.10.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}