{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:24:33Z","timestamp":1773717873446,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23229009"],"award-info":[{"award-number":["23229009"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24592545"],"award-info":[{"award-number":["24592545"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.neulet.2013.11.062","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T20:33:59Z","timestamp":1386880439000},"page":"7-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea"],"prefix":"10.1016","volume":"560","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-4254","authenticated-orcid":false,"given":"Yushi","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-0710","authenticated-orcid":false,"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6964-5638","authenticated-orcid":false,"given":"Takayuki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2013.11.062_bib0005","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ijc.11487","article-title":"The IGF-1 receptor in cancer biology","volume":"107","author":"Baserga","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neulet.2013.11.062_bib0010","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/jmg.40.12.913","article-title":"A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency","volume":"40","author":"Bonapace","year":"2003","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neulet.2013.11.062_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1995.1031","article-title":"The earliest patterns of neuronal differentiation and migration in the mammalian central nervous system","volume":"134","author":"Brittis","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0020","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0006-2952(00)00422-6","article-title":"Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy","volume":"60","author":"Brodt","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0025","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1460-9568.2005.04584.x","article-title":"Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness","volume":"23","author":"Cediel","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2013.11.062_bib0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/157015906778520782","article-title":"Molecular mechanisms, biological actions, and neuropharmacology of the growth-associated protein GAP-43","volume":"4","author":"Denny","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0035","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1460-9568.1999.00455.x","article-title":"The protein kinase C (PKC) substrate GAP-43 is already expressed in neural precursor cells, colocalizes with PKCeta and binds calmodulin","volume":"11","author":"Esdar","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2013.11.062_bib0040","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0045","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/cdd.2008.188","article-title":"GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986","volume":"16","author":"Gupta","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2013.11.062_bib0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mcn.2013.03.003","article-title":"Insulin-like growth factor 1 inhibits hair-cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice","volume":"56","author":"Hayashi","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2013.11.062_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0896-6273(90)90444-K","article-title":"The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans","volume":"4","author":"Hedgecock","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2013.11.062_bib0060","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1523\/JNEUROSCI.06-06-01843.1986","article-title":"A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS","volume":"6","author":"Jacobson","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2013.11.062_bib0065","doi-asserted-by":"crossref","first-page":"e26776","DOI":"10.1371\/journal.pone.0026776","article-title":"Intracellular kinases mediate increased translation and secretion of netrin-1 from renal tubular epithelial cells","volume":"6","author":"Jayakumar","year":"2011","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.neulet.2013.11.062_bib0070","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1530\/eje.0.151s017","article-title":"Evidence for a link between IGF-I and cancer","volume":"151","author":"Jenkins","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0169-328X(96)00008-3","article-title":"GAP-43 mRNA expression in early development of human nervous system","volume":"38","author":"Kanazir","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2013.11.062_bib0080","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.044529","article-title":"Netrins: versatile extracellular cues with diverse functions","volume":"138","author":"Lai Wing Sun","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.neulet.2013.11.062_bib0085","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0006-8993(99)02042-9","article-title":"Targeted disruption of GAP-43 in P19 embryonal carcinoma cells inhibits neuronal differentiation. As well as acquisition of the morphological phenotype","volume":"853","author":"Mani","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2013.11.062_bib0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/mcne.2000.0931","article-title":"Failure to express GAP-43 during neurogenesis affects cell cycle regulation and differentiation of neural precursors and stimulates apoptosis of neurons","volume":"17","author":"Mani","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2013.11.062_bib0095","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1387\/ijdb.072273tm","article-title":"Analysis of Netrin 1 receptors during inner ear development","volume":"51","author":"Matilainen","year":"2007","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0100","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1073\/pnas.83.10.3537","article-title":"Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones","volume":"83","author":"Meiri","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neulet.2013.11.062_bib0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1741-7015-8-76","article-title":"Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial","volume":"8","author":"Nakagawa","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.neulet.2013.11.062_bib0110","doi-asserted-by":"crossref","first-page":"e8699","DOI":"10.1371\/journal.pone.0008699","article-title":"RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors","volume":"5","author":"Sanchez-Calderon","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2013.11.062_bib0115","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1126\/science.3738509","article-title":"A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes","volume":"233","author":"Skene","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.neulet.2013.11.062_bib0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/mp.54.3.133","article-title":"IGF-I receptor signalling in transformation and differentiation","volume":"54","author":"Valentinis","year":"2001","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/MN:28:1:23","article-title":"Cell death in the nervous system: lessons from insulin and insulin-like growth factors","volume":"28","author":"Varela-Nieto","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0130","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2174\/138161207780249164","article-title":"Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation","volume":"13","author":"Varela-Nieto","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neulet.2013.11.062_bib0135","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1210\/jc.2004-1254","article-title":"Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation","volume":"90","author":"Walenkamp","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2013.11.062_bib0140","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2353\/ajpath.2009.090224","article-title":"Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis","volume":"175","author":"Wang","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0145","doi-asserted-by":"crossref","first-page":"F723","DOI":"10.1152\/ajprenal.90686.2008","article-title":"Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor","volume":"296","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.neulet.2013.11.062_bib0150","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM199610313351805","article-title":"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene","volume":"335","author":"Woods","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2013.11.062_bib0155","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1073\/pnas.0130116100","article-title":"Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis","volume":"100","author":"Yabe","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neulet.2013.11.062_bib0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00109-005-0706-9","article-title":"Inhibition of Notch\/RBP-J signaling induces hair cell formation in neonate mouse cochleas","volume":"84","author":"Yamamoto","year":"2006","journal-title":"J. Mol. Med. (Berl)"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013010811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394013010811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:17:02Z","timestamp":1759609022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394013010811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":32,"alternative-id":["S0304394013010811"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2013.11.062","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2013.11.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}