{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:21:56Z","timestamp":1791278516012,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neulet.2014.03.037","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T04:46:38Z","timestamp":1396068398000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"special_numbering":"C","title":["Apelin-13 protects the brain against ischemia\/reperfusion injury through activating PI3K\/Akt and ERK1\/2 signaling pathways"],"prefix":"10.1016","volume":"568","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2014.03.037_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrn1106","article-title":"Mechanisms, challenges and opportunities in stroke","volume":"4","author":"Lo","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2014.03.037_bib0010","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2014.03.037_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.regpep.2005.01.013","article-title":"Apelin cells in the rat stomach","volume":"129","author":"Susaki","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2014.03.037_bib0020","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1152\/ajpheart.00097.2011","article-title":"Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion","volume":"301","author":"Tao","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neulet.2014.03.037_bib0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12031-012-9808-3","article-title":"Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia","volume":"48","author":"Khaksari","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2014.03.037_bib0030","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1161\/STROKEAHA.107.490904","article-title":"Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke","volume":"38","author":"Li","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2014.03.037_bib0035","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2014.03.037_bib0040","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1523\/JNEUROSCI.4288-04.2005","article-title":"Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133","volume":"25","author":"Lee","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2014.03.037_bib0045","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/jcbfm.1988.96","article-title":"Ischemic brain edema and the osomotic gradient between blood and brain","volume":"8","author":"Hatashita","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2014.03.037_bib0050","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"ischemic cell death in brain neurons","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2014.03.037_bib0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35040009","article-title":"Apoptosis in neurodegenerative disorders","volume":"1","author":"Mattson","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neulet.2014.03.037_bib0060","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(03)00601-9","article-title":"Diversity in the mechanisms of neuronal cell death","volume":"40","author":"Yuan","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2014.03.037_bib0065","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10495-005-1681-x","article-title":"Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons","volume":"10","author":"Chauvier","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.neulet.2014.03.037_bib0070","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","article-title":"Death receptors: signaling and modulation","volume":"281","author":"Ashkenazi","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neulet.2014.03.037_bib0075","first-page":"2922","article-title":"The expanding role of mitochondria in apoptosis","volume":"15","author":"Wang","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2014.03.037_bib0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0074-7696(02)21011-6","article-title":"Molecular mechanisms of cerebral ischemia-induced neuronal death","volume":"221","author":"Hou","year":"2002","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.neulet.2014.03.037_bib0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.immunol.17.1.331","article-title":"Tumor necrosis factor receptor and Fas signaling mechanisms","volume":"17","author":"Wallach","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neulet.2014.03.037_bib0090","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1523\/JNEUROSCI.21-18-07127.2001","article-title":"Specific caspase pathways are activated in the two stages of cerebral infarction","volume":"21","author":"Benchoua","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2014.03.037_bib0095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cardiores.2003.09.031","article-title":"Protein kinase activation and myocardial ischemia\/reperfusion injury","volume":"3","author":"Armstrong","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neulet.2014.03.037_bib0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/excr.2000.4836","article-title":"Serine\/threonine protein kinases and apoptosis","volume":"1","author":"Cross","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neulet.2014.03.037_bib0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/156802606777057553","article-title":"Survival signaling pathways activated by NMDA receptors","volume":"8","author":"Hetman","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.neulet.2014.03.037_bib0110","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/j.1471-4159.2007.04645.x","article-title":"Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury","volume":"102","author":"O\u2019Donnell","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2014.03.037_bib0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.regpep.2007.10.002","article-title":"Apelin reduces myocardial reperfusion injury independently of PI3K\/Akt and P70S6 kinase","volume":"146","author":"Kleinz","year":"2008","journal-title":"Regul. Pept."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014002365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014002365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T21:56:30Z","timestamp":1565301390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394014002365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":23,"alternative-id":["S0304394014002365"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2014.03.037","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin-13 protects the brain against ischemia\/reperfusion injury through activating PI3K\/Akt and ERK1\/2 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2014.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}