{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:04:20Z","timestamp":1784873060988,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":355,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Rio Grande do Sul","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neulet.2014.03.063","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T15:18:59Z","timestamp":1396538339000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain"],"prefix":"10.1016","volume":"569","author":[{"given":"Andr\u00e9a","family":"Horst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Kolberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira S.","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula K.","family":"Riffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela A.","family":"Finamor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane","family":"Bell\u00f3-Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Am\u00e1lia","family":"Pavanato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wania A.","family":"Partata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2014.03.063_bib0005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejpain.2005.08.006","article-title":"Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-l-cysteine in rats","volume":"10","author":"Naik","year":"2006","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.neulet.2014.03.063_bib0010","doi-asserted-by":"crossref","first-page":"e41086","DOI":"10.1371\/journal.pone.0041086","article-title":"Neuroprotective effects of N-acetyl-cysteine and acetyl-l-carnitine after spinal cord injury in adult rats","volume":"7","author":"Karalija","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2014.03.063_bib0015","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bjps.2005.04.012","article-title":"Motorneuron protection by N-acetyl-cysteine after ventral root avulsion and ventral rhizotomy","volume":"58","author":"Zhang","year":"2005","journal-title":"Br. J. Plast. Surg."},{"key":"10.1016\/j.neulet.2014.03.063_bib0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2009.06.038","article-title":"Effects of N-acetyl-cysteine on the survival and regeneration of sural sensory neurons in adult rats","volume":"1287","author":"Welin","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2014.03.063_bib0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2003.12.040","article-title":"Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury","volume":"125","author":"Hart","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2014.03.063_bib0030","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12011-012-9320-1","article-title":"N-acetylcysteine attenuates copper overload-induced oxidative injury in brain of rat","volume":"147","author":"\u00d6zcelik","year":"2012","journal-title":"Biol. Trace. Elem. Res."},{"key":"10.1016\/j.neulet.2014.03.063_bib0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/niox.2001.0356","article-title":"N-acetylcysteine inhibits in vivo nitric oxide production by inducible nitric oxide synthase","volume":"5","author":"Bergamini","year":"2001","journal-title":"Nitric Oxide: Biol. Chem."},{"key":"10.1016\/j.neulet.2014.03.063_bib0040","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","article-title":"The chemistry and biological activities of N-acetylcysteine","volume":"1830","author":"Samuni","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2014.03.063_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(00)00306-1","article-title":"Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology","volume":"153","author":"Mat\u00e9s","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.neulet.2014.03.063_bib0050","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2006.8.1941","article-title":"Redox control of neural function: background, mechanisms, and significance","volume":"8","author":"Maher","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neulet.2014.03.063_bib0055","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1053\/meta.2002.35192","article-title":"Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin dependent diabetes mellitus","volume":"51","author":"Dincer","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.neulet.2014.03.063_bib0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1155\/2013\/147043","article-title":"Effects of hyperbaric oxygen on pain-related behaviours and nitric oxide synthase expression in a rat model of neuropathic pain","volume":"18","author":"Han","year":"2013","journal-title":"Pain Res. Manag."},{"key":"10.1016\/j.neulet.2014.03.063_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2014.03.063_bib0070","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1007\/s11064-012-0815-0","article-title":"Assessment of oxidative parameters in rat spinal cord after chronic constriction of the sciatic nerve","volume":"37","author":"Goecks","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2014.03.063_bib0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neulet.2014.03.063_bib0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0076-6879(81)77030-7","article-title":"Glutathione transferase (human placenta)","volume":"77","author":"Mannervik","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neulet.2014.03.063_bib0085","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0076-6879(81)77050-2","article-title":"Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples","volume":"77","author":"Akerboom","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neulet.2014.03.063_bib0090","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10571-008-9279-9","article-title":"Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain","volume":"28","author":"Guedes","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2014.03.063_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0076-6879(99)01068-X","article-title":"Measuring nitric oxide production in human clinical studies","volume":"301","author":"Granger","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neulet.2014.03.063_bib0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2014.03.063_bib0105","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jpain.2009.09.016","article-title":"Spinal levels of nonprotein thiols are related to nociception in mice","volume":"11","author":"Rossato","year":"2010","journal-title":"J. Pain"},{"key":"10.1016\/j.neulet.2014.03.063_bib0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1744-8069-8-77","article-title":"N-acetylcysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors","volume":"8","author":"Bernabucci","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neulet.2014.03.063_bib0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s002210050886","article-title":"Different strains and substrains of rats show different levels of neuropathic pain behaviors","volume":"129","author":"Yoon","year":"1999","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neulet.2014.03.063_bib0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system xc (\u2212): cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.neulet.2014.03.063_bib0125","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/sc.2010.21","article-title":"Comparison of changes in mRNA expression of spinal glutamate transporters following induction of two neuropathic pain models","volume":"48","author":"Mirzaei","year":"2010","journal-title":"Spinal Cord"},{"key":"10.1016\/j.neulet.2014.03.063_bib0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00726-010-0633-0","article-title":"Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain","volume":"42","author":"Little","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.neulet.2014.03.063_bib0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.niox.2011.06.004","article-title":"Pain and analgesia: the dual effect of nitric oxide in the nociceptive system","volume":"25","author":"Cury","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.neulet.2014.03.063_bib0140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-2094-8-6","article-title":"Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain","volume":"8","author":"Mei","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2014.03.063_bib0145","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ejpain.2011.04.005","article-title":"Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury","volume":"15","author":"Anand","year":"2011","journal-title":"Eur. J. Pain"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014002626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014002626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T18:42:38Z","timestamp":1648752158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394014002626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":29,"alternative-id":["S0304394014002626"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2014.03.063","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2014.03.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}