{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:24:58Z","timestamp":1759616698799,"version":"3.40.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministerio de Ciencia e Innovacion","award":["PSI2011-28934\/PSIC"],"award-info":[{"award-number":["PSI2011-28934\/PSIC"]}]},{"name":"CICYT","award":["BES-2009-024438"],"award-info":[{"award-number":["BES-2009-024438"]}]},{"name":"Red de Trastornos Adictivos, Ministerio de Sanidad y Politica Social","award":["RD06\/0001\/0028"],"award-info":[{"award-number":["RD06\/0001\/0028"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.neulet.2014.07.046","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T21:46:07Z","timestamp":1407015967000},"page":"68-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation"],"prefix":"10.1016","volume":"580","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-5585","authenticated-orcid":false,"given":"E.","family":"Tarragon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bali\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.G.","family":"Aragon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2014.07.046_bib0005","doi-asserted-by":"crossref","first-page":"re7","DOI":"10.1126\/scisignal.128re7","article-title":"Ethanol's molecular targets","volume":"1","author":"Harris","year":"2008","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neulet.2014.07.046_bib0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/jm9902741","article-title":"N-terminal dipeptides of d(\u2212)-penicillamine as sequestration agents for acetaldehyde","volume":"43","author":"Cohen","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neulet.2014.07.046_bib0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-2952(92)90042-H","article-title":"Ethanol metabolism in rat brain homogenates by a catalase\u2013H2O2 system","volume":"44","author":"Aragon","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/alcalc\/agm059","article-title":"Ethanol oxidation in the living brain","volume":"42","author":"Zimatkin","year":"2007","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1874473710801010003","article-title":"Putative role of brain acetaldehyde in ethanol addiction","volume":"1","author":"Deng","year":"2008","journal-title":"Curr. Drug Abuse Rev."},{"key":"10.1016\/j.neulet.2014.07.046_bib0030","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/138920007782109797","article-title":"Brain metabolism of ethanol and alcoholism: an update","volume":"8","author":"Hipolito","year":"2007","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.neulet.2014.07.046_bib0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00213-011-2407-0","article-title":"alpha-Lipoic acid, a scavenging agent for H(2)O(2), reduces ethanol-stimulated locomotion in mice","volume":"219","author":"Ledesma","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/acer.12253","article-title":"Reduction in central H(2)O(2) levels prevents voluntary ethanol intake in mice: a role for the brain catalase\u2013H(2)O(2) system in alcohol binge drinking","volume":"38","author":"Ledesma","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0045","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/acer.12169","article-title":"Alpha-lipoic acid reduces ethanol self-administration in rats","volume":"37","author":"Peana","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0050","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12097","article-title":"Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area","author":"Melis","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0055","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0028-3908(92)90150-N","article-title":"The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: evidence for brain catalase involvement in the mechanism of action","volume":"31","author":"Aragon","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.15288\/jsa.2000.61.493","article-title":"A psychopharmacological study of the relationship between brain catalase activity and ethanol-induced locomotor activity in mice","volume":"61","author":"Escarabajal","year":"2000","journal-title":"J. Stud. Alcohol"},{"key":"10.1016\/j.neulet.2014.07.046_bib0065","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.physbeh.2007.11.026","article-title":"Involvement of brain catalase activity in the acquisition of ethanol-induced conditioned place preference","volume":"93","author":"Font","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2014.07.046_bib0070","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/01.ALC.0000171945.30494.AF","article-title":"Prevention of ethanol-induced behavioral stimulation by d-penicillamine: a sequestration agent for acetaldehyde","volume":"29","author":"Font","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00213-013-3065-1","article-title":"Efficacy of d-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse-like drinking in rats","volume":"228","author":"Orrico","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1530-0277.2007.00574.x","article-title":"Key role of ethanol-derived acetaldehyde in the motivational properties induced by intragastric ethanol: a conditioned place preference study in the rat","volume":"32","author":"Peana","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2010.07.081","article-title":"Systemic administration of d-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats","volume":"483","author":"Marti-Prats","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2014.07.046_bib0090","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00213-012-2920-9","article-title":"The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats","volume":"226","author":"March","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00213-004-1911-x","article-title":"Behavioral characterization of acetaldehyde in C57BL\/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects","volume":"177","author":"Quertemont","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0100","first-page":"1974","article-title":"Exogenous sodium hydrosulfide can attenuate naloxone-precipitated withdrawal syndromes and affect cAMP signaling pathway in heroin-dependent rat's nucleus accumbens","volume":"16","author":"Jiang","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.neulet.2014.07.046_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1997.77.1.1","article-title":"Cellular and molecular neuroscience of alcoholism","volume":"77","author":"Diamond","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2014.07.046_bib0110","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1523\/JNEUROSCI.4273-04.2005","article-title":"Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity","volume":"25","author":"Maas","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2014.07.046_bib0115","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/acer.12289","article-title":"In vivo study of ethanol-activated brain protein kinase A: manipulations of Ca2+ distribution and flux","volume":"38","author":"Balino","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0120","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1523\/JNEUROSCI.21-14-05297.2001","article-title":"The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol","volume":"21","author":"Wand","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2014.07.046_bib0125","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1172\/JCI24381","article-title":"Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism","volume":"115","author":"Pandey","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neulet.2014.07.046_bib0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1369-1600.2011.00336.x","article-title":"Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice","volume":"17","author":"Hayes","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0135","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-012-2831-9","article-title":"Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H(2)O(2) scavenger alpha lipoic acid","volume":"226","author":"Ledesma","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0140","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0016-5085(87)91072-9","article-title":"Early invasive cancer in adenomatous colonic polyps (malignant polyps). Evaluation of the therapeutic options by decision analysis","volume":"92","author":"Wilcox","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0145","doi-asserted-by":"crossref","first-page":"10217","DOI":"10.1073\/pnas.93.19.10217","article-title":"Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus","volume":"93","author":"Dohrman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2014.07.046_bib0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1124\/jpet.301.1.66","article-title":"Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase","volume":"301","author":"Asher","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2014.07.046_bib0155","first-page":"930","article-title":"Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal","volume":"24","author":"Li","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neulet.2014.07.046_bib0160","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neubiorev.2011.07.009","article-title":"Piecing together the puzzle of acetaldehyde as a neuroactive agent","volume":"36","author":"Correa","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2014.07.046_bib0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.drugalcdep.2011.12.003","article-title":"The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice","volume":"124","author":"Ledesma","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neulet.2014.07.046_bib0170","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbr.2012.05.046","article-title":"Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex","volume":"233","author":"Tarragon","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0175","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.expneurol.2012.01.016","article-title":"Intracellular calcium chelation with BAPTA-AM modulates ethanol-induced behavioral effects in mice","volume":"234","author":"Balino","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0180","article-title":"Role of Ca2+\/calmodulin on ethanol neurobehavioral effects","author":"Balino","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2014.07.046_bib0185","doi-asserted-by":"crossref","first-page":"C1366","DOI":"10.1152\/ajpcell.2000.279.5.C1366","article-title":"H(2)O(2) and ethanol act synergistically to gate ryanodine receptor\/calcium-release channel","volume":"279","author":"Oba","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0190","doi-asserted-by":"crossref","first-page":"C1188","DOI":"10.1152\/ajpcell.00388.2003","article-title":"Acetaldehyde alters Ca2+-release channel gating and muscle contraction in a dose-dependent manner","volume":"286","author":"Oba","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2007.08.040","article-title":"Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes","volume":"1178","author":"Gonzalez","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2014.07.046_bib0200","doi-asserted-by":"crossref","first-page":"H121","DOI":"10.1152\/ajpheart.00520.2007","article-title":"Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum","volume":"294","author":"Oba","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neulet.2014.07.046_bib0205","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0022-3565(24)38104-2","article-title":"Necessary role for ventral tegmental area adenylate cyclase and protein kinase A in induction of behavioral sensitization to intraventral tegmental area amphetamine","volume":"289","author":"Tolliver","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2014.07.046_bib0210","doi-asserted-by":"crossref","first-page":"RC75","DOI":"10.1523\/JNEUROSCI.20-10-j0003.2000","article-title":"High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice","volume":"20","author":"Thiele","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2014.07.046_bib0215","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.drugalcdep.2005.02.007","article-title":"Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice","volume":"79","author":"Manrique","year":"2005","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neulet.2014.07.046_bib0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0376-8716(01)00142-9","article-title":"Influence of brain catalase on ethanol-induced loss of righting reflex in mice","volume":"65","author":"Correa","year":"2001","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neulet.2014.07.046_bib0225","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-008-1219-3","article-title":"Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde: the role of catalase inhibitors and acetaldehyde-sequestering agents","volume":"200","author":"Correa","year":"2008","journal-title":"Psychopharmacology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014006272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014006272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:52:12Z","timestamp":1746323532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394014006272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":45,"alternative-id":["S0304394014006272"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2014.07.046","relation":{},"ISSN":["0304-3940"],"issn-type":[{"type":"print","value":"0304-3940"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2014.07.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}