{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:09Z","timestamp":1786994769126,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Scientific Research Common Program of Beijing Municipal Commission of Education","award":["KZ201210025028"],"award-info":[{"award-number":["KZ201210025028"]}]},{"name":"Beijing municipal science and technology plan","award":["Z11110005880000"],"award-info":[{"award-number":["Z11110005880000"]}]},{"name":"High Level Technical Talent Training Program in Beijing Healthcare System","award":["2011-3-022"],"award-info":[{"award-number":["2011-3-022"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.neulet.2014.08.053","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T07:34:38Z","timestamp":1410334478000},"page":"99-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The predictive value of transcranial sonography in clinically diagnosed patients with early stage Parkinson's disease: Comparison with DAT PET scans"],"prefix":"10.1016","volume":"582","author":[{"given":"Ping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-hong","family":"Ou-Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2014.08.053_bib0005","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2014.08.053_bib0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/NRL.0b013e318183fdd8","article-title":"Molecular imaging studies in Parkinson disease: reducing diagnostic uncertainty","volume":"15","author":"Felicio","year":"2009","journal-title":"Neurologist"},{"key":"10.1016\/j.neulet.2014.08.053_bib0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-3-211-45295-0_38","article-title":"Transcranial sonography in the early and differential diagnosis of Parkinson's disease","author":"Berg","year":"2006","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.neulet.2014.08.053_bib0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/ene.12022","article-title":"EFNS\/MDS-ES\/ENS [corrected] recommendations for the diagnosis of Parkinson's disease","volume":"20","author":"Berardelli","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-002613","article-title":"Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients","volume":"3","author":"Bouwmans","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.neulet.2014.08.053_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jnnp.2008.157370","article-title":"The role of DAT-SPECT in movement disorders","volume":"81","author":"Kagi","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2014.08.053_bib0035","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2014.08.053_bib0040","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1212\/WNL.53.5.1026","article-title":"Vulnerability of the nigrostriatal system as detected by transcranial ultrasound","volume":"53","author":"Berg","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2014.08.053_bib0045","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1001\/archneur.64.11.1635","article-title":"Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson disease","volume":"64","author":"Walter","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0050","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/S0317167100038051","article-title":"Systemic therapy of dystonia","volume":"14","author":"Fahn","year":"1987","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2014.08.053_bib0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.45.1.182","article-title":"Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography","volume":"45","author":"Becker","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2014.08.053_bib0060","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s004150170114","article-title":"Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings","volume":"248","author":"Berg","year":"2001","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s007020200015","article-title":"Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease","volume":"109","author":"Walter","year":"2002","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.neulet.2014.08.053_bib0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0404.2008.01056.x","article-title":"Distinguishing Parkinson's disease and essential tremor with transcranial sonography","volume":"119","author":"Budisic","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neulet.2014.08.053_bib0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2377-8-42","article-title":"The predictive value of transcranial duplex sonography for the clinical diagnosis in undiagnosed parkinsonian syndromes: comparison with SPECT scans","volume":"8","author":"Vlaar","year":"2008","journal-title":"BMC Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0080","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1474-4422(08)70067-X","article-title":"The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study","volume":"7","author":"Gaenslen","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0085","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1001\/archneur.61.8.1224","article-title":"(123I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis","volume":"61","author":"Jennings","year":"2004","journal-title":"Arch Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ageing\/28.2.99","article-title":"Accuracy of diagnosis in patients with presumed Parkinson's disease","volume":"28","author":"Meara","year":"1999","journal-title":"Age Ageing"},{"key":"10.1016\/j.neulet.2014.08.053_bib0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/jnnp.73.5.529","article-title":"How valid is the clinical diagnosis of Parkinson's disease in the community","volume":"73","author":"Schrag","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2014.08.053_bib0100","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1212\/WNL.57.8.1497","article-title":"Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease","volume":"57","author":"Hughes","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2014.08.053_bib0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S0317167100031814","article-title":"Accuracy of clinical diagnosis in parkinsonism \u2013 a prospective study","volume":"18","author":"Rajput","year":"1991","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2014.08.053_bib0110","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jns.2009.12.024","article-title":"Evaluation of patients with clinically unclear Parkinsonian syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1","volume":"291","author":"Felicio","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2014.08.053_bib0115","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2967\/jnumed.106.037432","article-title":"Optimized, automated striatal uptake analysis applied to SPECT brain scans of Parkinson's disease patients","volume":"48","author":"Zubal","year":"2007","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.neulet.2014.08.053_bib0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00415-006-0403-9","article-title":"Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism","volume":"254","author":"Tsai","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2014.08.053_bib0125","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/mds.22665","article-title":"Substantia nigra echogenicity: a structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease","volume":"24","author":"Weise","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2014.08.053_bib0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/mds.20311","article-title":"Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease","volume":"20","author":"Berg","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2014.08.053_bib0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mds.20669","article-title":"Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease","volume":"21","author":"Schweitzer","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2014.08.053_bib0140","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/mds.21372","article-title":"Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease","volume":"22","author":"Huang","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2014.08.053_bib0145","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/brain\/awl042","article-title":"Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease","volume":"129","author":"Spiegel","year":"2006","journal-title":"Brain"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014007368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394014007368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T19:00:34Z","timestamp":1538247634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394014007368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":29,"alternative-id":["S0304394014007368"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2014.08.053","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The predictive value of transcranial sonography in clinically diagnosed patients with early stage Parkinson's disease: Comparison with DAT PET scans","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2014.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}