{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:08:53Z","timestamp":1790662133160,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.neulet.2015.01.084","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T17:07:08Z","timestamp":1424106428000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain"],"prefix":"10.1016","volume":"594","author":[{"given":"L.","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Kopach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Minett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.T.","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Meert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.N.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.01.084_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1651-2227.2002.tb03102.x","article-title":"Angiokeratoma corporis diffusum\u2013Fabry disease: historical review from the original description to the introduction of enzyme replacement therapy","volume":"91","author":"Fabry","year":"2002","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.neulet.2015.01.084_bib0010","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ana.410230513","article-title":"Nervous system involvement in Fabry\u2019s disease: clinicopathological and biochemical correlation","volume":"23","author":"Kaye","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2015.01.084_bib0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncpneuro0407","article-title":"Neurological manifestations in Fabry\u2019s disease","volume":"3","author":"M\u00f8ller","year":"2007","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.neulet.2015.01.084_bib0020","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00004691-200212000-00011","article-title":"Small fiber dysfunction predominates in Fabry neuropathy","volume":"19","author":"D\u00fctsch","year":"2002","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.neulet.2015.01.084_bib0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10545-005-5263-4","article-title":"Measurement of urinary CDH and CTH by tandem mass spectrometry in patients hemizygous and heterozygous for Fabry disease","volume":"28","author":"Mills","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neulet.2015.01.084_bib0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/08035320510028111","article-title":"Is globotriaosylceramide a useful biomarker in Fabry disease?","volume":"94","author":"Young","year":"2005","journal-title":"Acta Pediatr. Suppl."},{"key":"10.1016\/j.neulet.2015.01.084_bib0035","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1073\/pnas.0712309105","article-title":"Elevated globotriaosylsphingosine is a hallmark of Fabry disease","volume":"105","author":"Aerts","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2015.01.084_bib0040","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1073\/pnas.94.6.2540","article-title":"Alpha-galactosidase A deficient mice: a model of Fabry disease","volume":"94","author":"Ohshima","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2015.01.084_bib0045","doi-asserted-by":"crossref","first-page":"e57631","DOI":"10.1371\/journal.pone.0057631","article-title":"Migalastat HCl reduces globotriaosylsphingosine (lyso-Gb3) in Fabry transgenic mice and in the plasma of Fabry patients","volume":"8","author":"Young-Gqamana","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2015.01.084_bib0050","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1517\/21678707.2013.780970","article-title":"Emerging therapies and therapeutic concepts for lysosomal storage diseases","volume":"1","author":"Kierkegaard","year":"2013","journal-title":"Expert Opin. Orphan Drugs"},{"key":"10.1016\/j.neulet.2015.01.084_bib0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2015.01.084_bib0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ncomms1795","article-title":"Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons","volume":"3","author":"Minett","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2015.01.084_bib0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/092986713804806685","article-title":"A metabolomic study reveals novel plasma lyso-Gb3 analogs as Fabry disease biomarkers","volume":"20","author":"Dupont","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neulet.2015.01.084_bib0070","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1021\/ac401542k","article-title":"A metabolomic study to identify new globotriaosylceramide-related biomarkers in the plasma of Fabry disease patients","volume":"85","author":"Manwaring","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.neulet.2015.01.084_bib0075","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999","article-title":"Isolectin B(4)-positive and -negative nociceptors are functionally distinct","volume":"19","author":"Stucky","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.01.084_bib0080","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1152\/jn.00371.2002","article-title":"Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicin","volume":"89","author":"Dirajlal","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2015.01.084_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neulet.2015.01.084_bib0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.md.0000178976.62537.6b","article-title":"The relationship of vascular glycolipid storage to clinical manifestations of Fabry disease: a cross-sectional study of a large cohort of clinically affected heterozygous women","volume":"84","author":"Gupta","year":"2005","journal-title":"Med. (Baltimore)"},{"key":"10.1016\/j.neulet.2015.01.084_bib0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium dependent neurodegeneration in excitotoxicity","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neulet.2015.01.084_bib0100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0306-4522(99)00453-4","article-title":"Effect of streptozotocin-induced diabetes on the activity of calcium channels in rat dorsal horn neurons","volume":"95","author":"Voitenko","year":"2000","journal-title":"Neuroscience"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015001196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015001196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:53:59Z","timestamp":1566330839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015001196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":20,"alternative-id":["S0304394015001196"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.01.084","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.01.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}