{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:02:53Z","timestamp":1791270173575,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.neulet.2015.07.005","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:39:42Z","timestamp":1436315982000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Alpha-synuclein immunoreactivity patterns in the enteric nervous system"],"prefix":"10.1016","volume":"602","author":[{"given":"Iban","family":"Aldecoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Navarro-Otano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Stefanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne S.","family":"Sprenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cuatrecasas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Valldeoriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Tolosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6645","key":"10.1016\/j.neulet.2015.07.005_bib0005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.neulet.2015.07.005_bib0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Arizona Parkinson's Disease Consortium, multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.neulet.2015.07.005_bib0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric alpha-synuclein immunoreactive inclusions in Meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson's disease-related brain pathology","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.neulet.2015.07.005_bib0020","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00401-010-0665-2","article-title":"Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease","volume":"119","author":"Del Tredici","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"8","key":"10.1016\/j.neulet.2015.07.005_bib0025","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/mds.25776","article-title":"Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders","volume":"29","author":"Gelpi","year":"2014","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.neulet.2015.07.005_bib0030","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1111\/j.1365-2982.2009.01368.x","article-title":"Routine colonic biopsies as a new tool to study the enteric nervous system in living patients","volume":"22","author":"Lebouvier","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"issue":"9","key":"10.1016\/j.neulet.2015.07.005_bib0035","doi-asserted-by":"crossref","first-page":"e12728","DOI":"10.1371\/journal.pone.0012728","article-title":"Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms","volume":"5","author":"Lebouvier","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neulet.2015.07.005_bib0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2011.08.014","article-title":"A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson\u2019s disease","volume":"45","author":"Pouclet","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.neulet.2015.07.005_bib0045","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1111\/j.1365-2982.2012.01887.x","article-title":"A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson\u2019s disease","volume":"24","author":"Pouclet","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"issue":"12","key":"10.1016\/j.neulet.2015.07.005_bib0050","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1136\/gut.2008.162503","article-title":"Pathological lesions in colonic biopsies during Parkinson\u2019s disease","volume":"57","author":"Lebouvier","year":"2008","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.neulet.2015.07.005_bib0055","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.parkreldis.2012.04.020","article-title":"Analysis of colonic alpha-synuclein pathology in multiple system atrophy","volume":"18","author":"Pouclet","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"issue":"6","key":"10.1016\/j.neulet.2015.07.005_bib0060","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/mds.23838","article-title":"Alpha-Synuclein in colonic submucosa in early untreated Parkinson's disease","volume":"27","author":"Shannon","year":"2012","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.neulet.2015.07.005_bib0065","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/mds.25020","article-title":"Is alpha-synuclein in the colon a biomarker for premotor Parkinson\u2019s disease? Evidence from 3 cases","volume":"27","author":"Shannon","year":"2012","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.neulet.2015.07.005_bib0070","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nbd.2012.07.018","article-title":"Expression pattern and localization of alpha-synuclein in the human enteric nervous system","volume":"48","author":"B\u00f6ttner","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.neulet.2015.07.005_bib0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/mds.25298","article-title":"Enteric alpha-synuclein expression is increased in Parkinson\u2019s disease but not Alzheimer\u2019s disease","volume":"28","author":"Gold","year":"2013","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.neulet.2015.07.005_bib0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-013-1214-6","article-title":"Accumulation of \u03b1\u2011synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease","volume":"127","author":"Hilton","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.neulet.2015.07.005_bib0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/mds.25988","article-title":"In vivo gastric detection of \u03b1-synuclein inclusions in Parkinson\u2019s disease","volume":"30","author":"S\u00e1nchez-Ferro","year":"2015","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.neulet.2015.07.005_bib0090","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1212\/WNL.0000000000001240","article-title":"Colonic mucosal \u03b1-synuclein lacks specificity as a biomarker for Parkinson disease","volume":"84","author":"Visanji","year":"2015","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.neulet.2015.07.005_bib0095","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1136\/jcp.2007.047720","article-title":"Technical pitfalls potentially affecting diagnoses in Immunohistochemistry","volume":"61","author":"Bussolati","year":"2008","journal-title":"J. Clin. Pathol."},{"issue":"12","key":"10.1016\/j.neulet.2015.07.005_bib0100","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnen\/62.12.1241","article-title":"Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62","volume":"62","author":"Kuusisto","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.neulet.2015.07.005_bib0105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/nen.0b013e3181633526","article-title":"Brainnet Europe Consortium, assessment of \u00e1-synuclein pathology: a study of the brainnet Europe Consortium","volume":"67","author":"Alafuzoff","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2015.07.005_bib0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2990.2006.00722.x","article-title":"Comparative study of commercially available anti-alpha-synuclein antibodies","volume":"32","author":"Croisier","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"2","key":"10.1016\/j.neulet.2015.07.005_bib0115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"Alpha synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"40","key":"10.1016\/j.neulet.2015.07.005_bib0120","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alphasynuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.neulet.2015.07.005_bib0125","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/mds.25789","article-title":"Alimentary, my dear Watson? The challenges of enteric \u03b1-synuclein as a Parkinson's disease biomarker","volume":"29","author":"Visanji","year":"2014","journal-title":"Mov. Disord."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015300239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015300239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:06:58Z","timestamp":1717970818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015300239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":25,"alternative-id":["S0304394015300239"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.07.005","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha-synuclein immunoreactivity patterns in the enteric nervous system","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}