{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:38:34Z","timestamp":1781188714123,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hamadan University of Medical Science, Hamadan, Iran"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.neulet.2015.07.050","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T19:08:47Z","timestamp":1438801727000},"page":"157-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats"],"prefix":"10.1016","volume":"604","author":[{"given":"Abdolrahman","family":"Sarihi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hosseini","family":"Panah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadegh","family":"Seif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Vafaeirad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Alaii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.07.050_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1463-1326.2002.00234.x","article-title":"Orexin reverses cholecystokinin-induced reduction in feeding","volume":"4","author":"Asakawa","year":"2002","journal-title":"Diabetes Obesity Metab."},{"key":"10.1016\/j.neulet.2015.07.050_bib0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pbb.2013.09.018","article-title":"Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test","volume":"112","author":"Azhdari-Zarmehri","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2015.07.050_bib0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yfrne.2007.05.003","article-title":"Topography in the preoptic region: differential regulation of appetitive and consummatory male sexual behaviors","volume":"28","author":"Balthazart","year":"2007","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0020","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.cbpa.2006.06.032","article-title":"Physiology of temperature regulation: comparative aspects","volume":"147","author":"Bicego","year":"2007","journal-title":"Comp. Biochem. Physiol. A: Mol. Integr. Physiol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/frne.1994.1010","article-title":"Osmoreceptors, osmoreception, and osmoregulation","volume":"15","author":"Bourque","year":"1994","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0030","doi-asserted-by":"crossref","first-page":"E332","DOI":"10.1152\/ajpendo.1983.245.4.E332","article-title":"Evidence for a longitudinal pathway in rat hypothalamus that controls FFA mobilization","volume":"245","author":"Coimbra","year":"1983","journal-title":"Am. J. Physiol.\u2014Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2015.07.050_bib0035","doi-asserted-by":"crossref","first-page":"E703","DOI":"10.1152\/ajpendo.1986.251.6.E703","article-title":"Insulin-sensitive glucoreceptors in rat preoptic area that regulate FFA mobilization","volume":"251","author":"Coimbra","year":"1986","journal-title":"Am. J. Physiol.\u2014Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2015.07.050_bib0040","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2015.07.050_bib0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.physbeh.2005.08.006","article-title":"Dopamine, the medial preoptic area, and male sexual behavior","volume":"86","author":"Dominguez","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2015.07.050_bib0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0006-8993(99)01824-7","article-title":"Food intake elicited by central administration of orexins\/hypocretins: identification of hypothalamic sites of action","volume":"842","author":"Dube","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.07.050_bib0055","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.160R007","article-title":"The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin","volume":"160","author":"Edwards","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0060","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/jn\/134.3.648","article-title":"Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism","volume":"134","author":"Fahrenkrog","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.neulet.2015.07.050_bib0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0006-8993(03)03158-5","article-title":"Medial preoptic area adrenergic receptors modulate glycemia and insulinemia in freely moving rats","volume":"985","author":"F\u00f3scolo","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.07.050_bib0070","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0306-4522(02)00877-1","article-title":"Orexin A (hypocretin-1) application at the medial preoptic area potentiates male sexual behavior in rats","volume":"116","author":"Gulia","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2015.07.050_bib0075","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0196-9781(99)00105-9","article-title":"Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat","volume":"20","author":"Haynes","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.neulet.2015.07.050_bib0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0167-0115(01)00346-9","article-title":"Feeding and activity induced by orexin A in the lateral hypothalamus in rats","volume":"104","author":"Kotz","year":"2002","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2015.07.050_bib0085","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuint.2007.02.004","article-title":"Noradrenergic afferents and receptors in the medial preoptic area: neuroanatomical and neurochemical links between the regulation of sleep and body temperature","volume":"50","author":"Kumar","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2015.07.050_bib0090","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2826.2007.01584.x","article-title":"Increased caloric intake on a fat-rich diet: role of ovarian steroids and galanin in the medial preoptic and paraventricular nuclei and anterior pituitary of female rats","volume":"19","author":"Leibowitz","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/bbrc.1998.9750","article-title":"Independent feeding and metabolic actions of orexins in mice","volume":"253","author":"Lubkin","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2015.07.050_bib0100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1385\/ENDO:28:3:271","article-title":"Regulatory role of excitatory amino acids in reproduction","volume":"28","author":"Mahesh","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.neulet.2015.07.050_bib0105","doi-asserted-by":"crossref","first-page":"E1367","DOI":"10.1152\/ajpendo.00413.2013","article-title":"The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA\/kainate receptors","volume":"305","author":"Mietlicki-Baase","year":"2013","journal-title":"Am. J. physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2015.07.050_bib0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00001756-200001170-00021","article-title":"Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites","volume":"11","author":"Mullett","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2015.07.050_bib0115","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2826.2006.01415.x","article-title":"Regulation by orexin of feeding behaviour and locomotor activity in the goldfish","volume":"18","author":"Nakamachi","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(85)91586-0","article-title":"Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity","volume":"333","author":"Nicholson","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.07.050_bib0125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1365-2826.1997.t01-1-00597.x","article-title":"Projection sites of medial preoptic area and ventral bed nucleus of the stria terminalis neurons that express Fos during maternal behavior in female rats","volume":"9","author":"Numan","year":"1997","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2015.07.050_bib0130","series-title":"The Rat Brain in Stereotaxic Coordinates George Paxinos","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.neulet.2015.07.050_bib0135","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.peptides.2005.12.009","article-title":"Neuropeptide Y administration into the amygdala alters high fat food intake","volume":"27","author":"Primeaux","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.neulet.2015.07.050_bib0140","first-page":"133","article-title":"Orexins a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner","volume":"78","author":"Pu","year":"1998","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2015.07.050_bib0145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neulet.2011.05.006","article-title":"The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area","volume":"498","author":"Rusyniak","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2015.07.050_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2015.07.050_bib0155","first-page":"5","article-title":"The functional neuroanatomy of corticotropin-releasing factor","volume":"172","author":"Sawchenko","year":"1993","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.neulet.2015.07.050_bib0160","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0196-9781(99)00120-5","article-title":"Structure, tissue distribution, and pharmacological characterization of Xenopus orexins","volume":"20","author":"Shibahara","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.neulet.2015.07.050_bib0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0006-8993(99)01136-1","article-title":"Feeding response to central orexins","volume":"821","author":"Sweet","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.07.050_bib0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.sleep.2007.03.013","article-title":"Hypothalamic control of sleep","volume":"8","author":"Szymusiak","year":"2007","journal-title":"Sleep Med."},{"key":"10.1016\/j.neulet.2015.07.050_bib0175","first-page":"358","article-title":"Neurochemical mechanisms of the septum in food getting conditioned responses in rats","volume":"26","author":"Talalaenko","year":"1976","journal-title":"Z. Vyssh. Nerv. Deiat. Im. I P Pavlova"},{"key":"10.1016\/j.neulet.2015.07.050_bib0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2006.09.075","article-title":"Orexin A in the rostrolateral hypothalamic area induces feeding by modulating GABAergic transmission","volume":"1125","author":"Thorpe","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.07.050_bib0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1037\/a0018928","article-title":"Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol","volume":"124","author":"Travers","year":"2010","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neulet.2015.07.050_bib0190","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1523\/JNEUROSCI.18-19-07962.1998","article-title":"Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin\/orexin","volume":"18","author":"van den Pol","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.07.050_bib0195","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000084893","article-title":"Differential regulation of female rat olfactory preference and copulatory pacing by the lateral septum and medial preoptic area","volume":"81","author":"Xiao","year":"2005","journal-title":"Neuroendocrinology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015300707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015300707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T02:53:21Z","timestamp":1567047201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015300707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":39,"alternative-id":["S0304394015300707"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.07.050","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.07.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}