{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:58:33Z","timestamp":1789905513608,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.neulet.2015.10.011","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T20:35:28Z","timestamp":1445286928000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Altered histamine neurotransmission in HPRT-deficient mice"],"prefix":"10.1016","volume":"609","author":[{"given":"Sarah K.","family":"Tschirner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Gutzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkhard","family":"Kaever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich H.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.10.011_bib0005","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1093\/brain\/awt202","article-title":"Lesch\u2013Nyhan disease international study group: genotype-phenotype correlations in neurogenetics: Lesch\u2013Nyhan disease as a model disorder","volume":"137","author":"Fu","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2015.10.011_bib0010","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/brain\/awl056","article-title":"Delineation of the motor disorder of Lesch\u2013Nyhan disease","volume":"129","author":"Jinnah","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2015.10.011_bib0015","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1017\/S135561770177703X","article-title":"Neurocognitive functioning in Lesch\u2013Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiency","volume":"7","author":"Schretlen","year":"2001","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neulet.2015.10.011_bib0020","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1017\/S0012162205001374","article-title":"Behavioral aspects in Lesch\u2013Nyhan disease and its variants","volume":"47","author":"Schretlen","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.neulet.2015.10.011_bib0025","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0165-0173(99)00094-6","article-title":"Lesch\u2013Nyhan disease and the basal ganglia","volume":"32","author":"Visser","year":"2000","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neulet.2015.10.011_bib0030","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1055\/s-2007-973462","article-title":"Dopamine receptor upregulation in Lesch\u2013Nyhan syndrome: a postmortem study","volume":"30","author":"Saito","year":"1999","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neulet.2015.10.011_bib0035","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0022-3565(25)10390-X","article-title":"Functional analysis of brain dopamine systems in a genetic mouse model of Lesch\u2013Nyhan syndrome","volume":"263","author":"Jinnah","year":"1992","journal-title":"J. Pharmacol. Exp.Ther."},{"key":"10.1016\/j.neulet.2015.10.011_bib0040","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1523\/JNEUROSCI.14-03-01164.1994","article-title":"Dopamine deficiency in a genetic mouse model of Lesch\u2013Nyhan disease","volume":"14","author":"Jinnah","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.10.011_bib0045","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1471-4159.1999.0720225.x","article-title":"Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch\u2013Nyhan disease","volume":"72","author":"Jinnah","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2015.10.011_bib0050","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0022-510X(88)90099-8","article-title":"Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch\u2013Nyhan syndrome","volume":"86","author":"Finger","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2015.10.011_bib0055","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0091-3057(02)00841-9","article-title":"Pharmacologic thresholds for self-injurious behavior in a genetic mouse model of Lesch\u2013Nyhan disease","volume":"73","author":"Kasim","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2015.10.011_bib0060","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01244933","article-title":"Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors","volume":"93","author":"Schlicker","year":"1993","journal-title":"J. Neural. Transm. Gen. Sect."},{"key":"10.1016\/j.neulet.2015.10.011_bib0065","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.neubiorev.2012.11.004","article-title":"The functional anatomy of Gilles de la Tourette syndrome","volume":"37","author":"Ganos","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2015.10.011_bib0070","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.braindev.2014.11.005","article-title":"Tourette syndrome: update","volume":"37","author":"Hallett","year":"2015","journal-title":"Brain Dev."},{"key":"10.1016\/j.neulet.2015.10.011_bib0075","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1056\/NEJMoa0907006","article-title":"l-Histidine decarboxylase and Tourette\u2019s syndrome","volume":"362","author":"Ercan-Sencicek","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2015.10.011_bib0080","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice","volume":"81","author":"Castellan Baldan","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2015.10.011_bib0085","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.neuron.2014.05.023","article-title":"Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice (erratum)","volume":"82","author":"Castellan Baldan","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2015.10.011_bib0090","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/326292a0","article-title":"HPRT-deficient (Lesch\u2013Nyhan) mouse embryos derived from germline colonization by cultured cells","volume":"326","author":"Hooper","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2015.10.011_bib0095","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ygeno.2008.09.014","article-title":"Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus","volume":"93","author":"Yang","year":"2009","journal-title":"Genomics"},{"key":"10.1016\/j.neulet.2015.10.011_bib0100","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrn1034","article-title":"The role of histamine and the tuberomamillary nucleus in the nervous system","volume":"4","author":"Haas","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2015.10.011_bib0105","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1046\/j.1471-4159.1997.68010142.x","article-title":"Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors","volume":"68","author":"Prell","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2015.10.011_bib0110","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0006-8993(76)91029-5","article-title":"Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area","volume":"106","author":"Garbag","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2015.10.011_bib0115","doi-asserted-by":"publisher","DOI":"10.1007\/BF02007743","article-title":"Measurement of histamine metabolites in brain and cerebrospinal fluid provides insights into histaminergic activity","volume":"41","author":"Prell","year":"1994","journal-title":"Agents Actions"},{"key":"10.1016\/j.neulet.2015.10.011_bib0120","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","article-title":"The physiology of brain histamine","volume":"63","author":"Brown","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2015.10.011_bib0125","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tins.2014.02.007","article-title":"The other side of the histamine H3 receptor","volume":"37","author":"Ellenbroek","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2015.10.011_bib0130","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1113\/jphysiol.2010.203257","article-title":"l-Dopa activates histaminergic neurons","volume":"589","author":"Yanovsky","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2015.10.011_bib0135","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/nen.0b013e3180515319","article-title":"Multifocal atrophy of cerebellar internal granular neurons in Lesch\u2013Nyhan disease: case reports and review","volume":"66","author":"Del Bigio","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2015.10.011_bib0140","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainresrev.2006.01.003","article-title":"The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration","volume":"52","author":"Zhu","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neulet.2015.10.011_bib0145","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1136\/jmedgenet-2013-101637","article-title":"Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families","volume":"50","author":"Karagiannidis","year":"2013","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neulet.2015.10.011_bib0150","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1046\/j.1460-9568.1999.00453.x","article-title":"Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington\u2019s and Parkinson\u2019s disease cases","volume":"11","author":"Goodchild","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2015.10.011_bib0155","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/syn.890150306","article-title":"Loss of striatal histamine H2 receptors in Huntington's chorea but not in Parkinson\u2019s disease: comparison with animal models","volume":"15","author":"Mart\u00ednez-Mir","year":"1993","journal-title":"Synapse"},{"key":"10.1016\/j.neulet.2015.10.011_bib0160","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mehy.2004.01.019","article-title":"The biochemical basis of the neurobehavioral abnormalities in the Lesch\u2013Nyhan syndrome: a hypothesis","volume":"63","author":"Neychev","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neulet.2015.10.011_bib0165","article-title":"Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions","author":"Rapanelli","year":"2015","journal-title":"Neuropharmacology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015301749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015301749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:24:22Z","timestamp":1748658262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015301749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":33,"alternative-id":["S0304394015301749"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.10.011","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered histamine neurotransmission in HPRT-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}