{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:31:54Z","timestamp":1778283114756,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2011CB200902"],"award-info":[{"award-number":["2011CB200902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2005CB522604"],"award-info":[{"award-number":["2005CB522604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["Yz200947"],"award-info":[{"award-number":["Yz200947"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["KSCX2-YW-R-2"],"award-info":[{"award-number":["KSCX2-YW-R-2"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.neulet.2015.11.003","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T05:48:07Z","timestamp":1453960087000},"page":"283-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effect of mutated defensin NP-1 on sciatic nerve regeneration after transection\u2014A pivot study"],"prefix":"10.1016","volume":"617","author":[{"given":"Chungui","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengming","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanmin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.11.003_bib0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1471-4906(02)02246-9","article-title":"Mammalian defensins in immunity: more than just microbicidal","volume":"23","author":"Yang","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0014-5793(93)81287-A","article-title":"Chemotactic and protease-inhibiting activities of antibiotic peptide precursors","volume":"371","author":"Verbanac","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neulet.2015.11.003_bib0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1365-2567.2002.01430.x","article-title":"Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells","volume":"106","author":"Duits","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.neulet.2015.11.003_bib0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/icb\/43.2.300","article-title":"The role of antimicrobial peptides in innate immunity","volume":"43","author":"Ganz","year":"2003","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/iai.45.1.150-154.1984","article-title":"Purification and antibacterial activities of antimicrobial peptides of rabbit granulocytes","volume":"45","author":"Selsted","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1016\/j.neulet.2015.11.003_bib0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11055-006-0018-8","article-title":"The role of defensin NP-1 in restoring the functions of an injured nerve trunk","volume":"36","author":"Nozdrachev","year":"2006","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0035","doi-asserted-by":"crossref","first-page":"e54966","DOI":"10.1371\/journal.pone.0054966","article-title":"A new strategy to produce a defensin: stable production of mutated NP-1 in nitrate reductase-deficient chlorella ellipsoidea","volume":"8","author":"Bai","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2015.11.003_bib0040","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF00270698","article-title":"Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve","volume":"66","author":"Bhisitkul","year":"1987","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neulet.2015.11.003_bib0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4522(00)00143-3","article-title":"Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures","volume":"98","author":"Coronas","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2015.11.003_bib0050","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1523\/JNEUROSCI.08-07-02394.1988","article-title":"Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons","volume":"8","author":"Lindsay","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.003_bib0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0014-4886(03)00173-0","article-title":"FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers","volume":"183","author":"Udina","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/exnr.2002.7878","article-title":"FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation","volume":"175","author":"Sulaiman","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0065","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1172\/JCI112120","article-title":"Defensins: natural peptide antibiotics of human neutrophils","volume":"76","author":"Ganz","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2015.11.003_bib0070","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1172\/JCI114394","article-title":"Monocyte-chemotactic activity of defensins from human neutrophils","volume":"84","author":"Territo","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2015.11.003_bib0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s004410100433","article-title":"Identification of a novel, multifunctional-defensin (human beta-defensin 3) with specific antimicrobial activity: its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction","volume":"306","author":"Garc\u00eda","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2015.11.003_bib0080","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1096\/fj.00-0865fje","article-title":"Human beta-defensin 4: a novel inducible peptide with a specific saltsensitive spectrum of antimicrobial activity","volume":"15","author":"Garc\u00eda","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2015.11.003_bib0085","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","article-title":"Identification of myelin-associated glycoprotein as a major myelinderived nhibitor of neurite growth","volume":"13","author":"McKerracher","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2015.11.003_bib0090","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/BF01179817","article-title":"Schwann cells degrade myelin and proliferate in the absence of macrophages: evidence from in vitro studies of Wallerian degeneration","volume":"24","author":"Fernandez-Valle","year":"1995","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.neulet.2015.11.003_bib0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/JMN:21:1:65","article-title":"Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3\/MAC-1)-mediated myelin phagocytosis in injury and disease","volume":"21","author":"Rotshenker","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.003_bib0100","first-page":"257","article-title":"Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells","volume":"11","author":"Chaly","year":"2000","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.neulet.2015.11.003_bib0105","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1523\/JNEUROSCI.22-08-03052.2002","article-title":"The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta","volume":"22","author":"Shamash","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.003_bib0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0162-3109(96)00118-X","article-title":"Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophages","volume":"35","author":"Ichinose","year":"1996","journal-title":"Immunopharmacol"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015302408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015302408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:44:48Z","timestamp":1777553088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015302408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":22,"alternative-id":["S0304394015302408"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.11.003","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of mutated defensin NP-1 on sciatic nerve regeneration after transection\u2014A pivot study","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}