{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:14:50Z","timestamp":1786133690715,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-10-1-0041"],"award-info":[{"award-number":["W81XWH-10-1-0041"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NRSA 10668225"],"award-info":[{"award-number":["NRSA 10668225"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.neulet.2015.11.038","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T07:30:34Z","timestamp":1449041434000},"page":"43-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis"],"prefix":"10.1016","volume":"612","author":[{"given":"Longbo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Bordey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.11.038_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2015.11.038_bib0010","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1172\/JCI25740","article-title":"HIF-1alpha: a master regulator of innate host defenses?","volume":"115","author":"Zarember","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2015.11.038_bib0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn1408","article-title":"HIF1 and oxygen sensing in the brain","volume":"5","author":"Sharp","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0020","doi-asserted-by":"crossref","first-page":"14259","DOI":"10.1523\/JNEUROSCI.4258-08.2008","article-title":"Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression","volume":"28","author":"Yeh","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0025","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.biocel.2013.04.011","article-title":"Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models","volume":"45","author":"de Lemos","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neulet.2015.11.038_bib0030","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/hmg\/ddt018","article-title":"Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex","volume":"22","author":"Feliciano","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2015.11.038_bib0035","first-page":"5173","article-title":"Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin","volume":"63","author":"El-Hashemite","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.neulet.2015.11.038_bib0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccr.2004.06.020","article-title":"Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes","volume":"6","author":"Brugarolas","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neulet.2015.11.038_bib0045","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1073\/pnas.0900465106","article-title":"mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome","volume":"106","author":"Shackelford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2015.11.038_bib0050","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s001090050102","article-title":"The role of nitric oxide in multiple sclerosis","volume":"75","author":"Parkinson","year":"1997","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.neulet.2015.11.038_bib0055","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/hmg\/ddr511","article-title":"Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion","volume":"21","author":"Feliciano","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2015.11.038_bib0060","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1523\/JNEUROSCI.1840-12.2013","article-title":"Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons","volume":"33","author":"Lafourcade","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0065","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1523\/JNEUROSCI.5540-06.2007","article-title":"A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival","volume":"27","author":"Meikle","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijdevneu.2013.02.008","article-title":"A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits","author":"Feliciano","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0075","article-title":"Imaging and recording subventricular zone progenitor cells in live tissue of postnatal mice","volume":"4","author":"Lacar","year":"2010","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0080","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuropharm.2010.01.010","article-title":"A symphony of signals conduct early and late stages of adult neurogenesis","volume":"58","author":"Pathania","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2015.11.038_bib0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuron.2014.09.009","article-title":"MEK-ERK1\/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR","volume":"84","author":"Zhang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2015.11.038_bib0090","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI44909","article-title":"Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice","volume":"121","author":"Feliciano","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2015.11.038_bib0095","doi-asserted-by":"crossref","first-page":"e38174","DOI":"10.1371\/journal.pone.0038174","article-title":"miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons","volume":"7","author":"Pathania","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2015.11.038_bib0100","doi-asserted-by":"crossref","DOI":"10.3791\/50197-v","article-title":"Neonatal subventricular zone electroporation","author":"Feliciano","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neulet.2015.11.038_bib0105","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2010.03.009","article-title":"NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network","volume":"65","author":"Platel","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2015.11.038_bib0110","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neulet.2015.11.038_bib0115","doi-asserted-by":"crossref","first-page":"e1517","DOI":"10.1371\/journal.pone.0001517","article-title":"Selective gene expression by postnatal electroporation during olfactory interneuron nurogenesis","volume":"3","author":"Chesler","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2015.11.038_bib0120","doi-asserted-by":"crossref","first-page":"e1883","DOI":"10.1371\/journal.pone.0001883","article-title":"Efficient in vivo electroporation of the postnatal rodent forebrain","volume":"3","author":"Boutin","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2015.11.038_bib0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8104-6-13","article-title":"Targeted electroporation of defined lateral ventricular walls: a novel and rapid method to study fate specification during postnatal forebrain neurogenesis","volume":"6","author":"Fernandez","year":"2011","journal-title":"Neural Dev."},{"key":"10.1016\/j.neulet.2015.11.038_bib0130","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12031-009-9326-0","article-title":"Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF","volume":"40","author":"Genetos","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2015.11.038_bib0135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuron.2009.12.001","article-title":"Genetically increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits","volume":"65","author":"Lin","year":"2010","journal-title":"Neuron"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015302767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015302767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:37:58Z","timestamp":1786131478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015302767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":27,"alternative-id":["S0304394015302767"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.11.038","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.11.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}