{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:39:48Z","timestamp":1767865188076,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY012223"],"award-info":[{"award-number":["R01 EY012223"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research to Prevent Blindness, Inc."}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neulet.2015.12.012","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T18:22:18Z","timestamp":1451326938000},"page":"11-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells"],"prefix":"10.1016","volume":"625","author":[{"given":"Heather M.","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra L.","family":"Schlamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-5494","authenticated-orcid":false,"given":"Robert W.","family":"Nickells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2015.12.012_bib0005","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.exer.2008.12.002","article-title":"Mouse models of retinal ganglion cell death and glaucoma","volume":"88","author":"McKinnon","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.neulet.2015.12.012_bib0010","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1167\/iovs.11-9310","article-title":"Nuclear atrophy of retinal ganglion cells precedes the bax-dependent stage of apoptosis","volume":"54","author":"Janssen","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2202-11-62","article-title":"Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis","volume":"11","author":"Pelzel","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1326-9-39","article-title":"Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury","volume":"9","author":"Schmitt","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neulet.2015.12.012_bib0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-213X-14-30","article-title":"Histone deacetylase expression patterns in developing murine optic nerve","volume":"14","author":"Tiwari","year":"2014","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.neulet.2015.12.012_bib0030","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2009.06.049","article-title":"Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes","volume":"138","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2015.12.012_bib0035","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s13311-013-0201-x","article-title":"Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury","volume":"10","author":"Baltan","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neulet.2015.12.012_bib0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1326-8-42","article-title":"Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model","volume":"8","author":"Duncan","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neulet.2015.12.012_bib0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","article-title":"Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington\u2019s disease","volume":"46","author":"Jia","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2015.12.012_bib0050","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"Malvaez","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2015.12.012_bib0055","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1167\/iovs.12-11529","article-title":"Inhibition of HDAC2 protects the retina from ischemic injury","volume":"54","author":"Fan","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0060","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0168-9525(02)02648-3","article-title":"Unravelling heterochromatin: competition between positive and negative factors regulates accessibility","volume":"18","author":"Dillon","year":"2002","journal-title":"Trends Genet."},{"key":"10.1016\/j.neulet.2015.12.012_bib0065","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neulet.2015.12.012_bib0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2015.12.012_bib0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"Enari","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2015.12.012_bib0080","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1167\/iovs.11-8872","article-title":"Silencing of Fem1cR3 gene expression in the DBA\/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity","volume":"53","author":"Pelzel","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0085","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1167\/iovs.07-0542","article-title":"Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms","volume":"48","author":"Yang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0090","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/gt.2008.178","article-title":"Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection","volume":"16","author":"Hellstrom","year":"2009","journal-title":"Gene Ther."},{"key":"10.1016\/j.neulet.2015.12.012_bib0095","doi-asserted-by":"crossref","DOI":"10.1177\/1759091415593066","article-title":"Combined HDAC1 and HDAC2 depletion promotes retinal ganglion cell survival after injury through reduction of p53 target gene expression","volume":"7","author":"Lebrun-Julien","year":"2015","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neulet.2015.12.012_bib0100","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1158\/1541-7786.MCR-07-0324","article-title":"Histone deacetylase inhibitors: overview and perspectives","volume":"5","author":"Dokmanovic","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.neulet.2015.12.012_bib0105","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1167\/iovs.09-3903","article-title":"Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells","volume":"51","author":"Biermann","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0110","first-page":"395","article-title":"Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells","volume":"17","author":"Biermann","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.neulet.2015.12.012_bib0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1167\/iovs.12-10850","article-title":"Inhibition of histone deacetylases 1 and 3 protects injured retinal ganglion cells","volume":"54","author":"Chindasub","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0120","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1167\/iovs.14-14792","article-title":"Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension","volume":"55","author":"Alsarraf","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0125","doi-asserted-by":"crossref","first-page":"e00032","DOI":"10.1042\/AN20100003","article-title":"A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death","volume":"2","author":"Semaan","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neulet.2015.12.012_bib0130","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1523\/JNEUROSCI.5704-10.2011","article-title":"Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta","volume":"31","author":"Bardai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0135","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1523\/JNEUROSCI.6186-08.2009","article-title":"Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms","volume":"29","author":"Uo","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0140","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1523\/JNEUROSCI.5214-12.2013","article-title":"Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons","volume":"33","author":"Brochier","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0145","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1128\/MCB.00062-06","article-title":"Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage","volume":"26","author":"Chao","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neulet.2015.12.012_bib0150","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.cdd.4401183","article-title":"Decision making by p53: life, death and cancer","volume":"10","author":"Oren","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2015.12.012_bib0155","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1371\/journal.pgen.0030127","article-title":"Divergent evolution of human p53 binding sites: cell cycle versus apoptosis","volume":"3","author":"Horvath","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neulet.2015.12.012_bib0160","doi-asserted-by":"crossref","first-page":"7901","DOI":"10.1038\/sj.onc.1205974","article-title":"Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites","volume":"21","author":"Qian","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.neulet.2015.12.012_bib0165","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/nar\/gkq1209","article-title":"Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements","volume":"39","author":"Millau","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neulet.2015.12.012_bib0170","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1523\/JNEUROSCI.2444-14.2015","article-title":"HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death","volume":"35","author":"Peng","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1523\/JNEUROSCI.3200-07.2008","article-title":"Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1\/cip1) in cell cycle-independent neuroprotection","volume":"28","author":"Langley","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2015.12.012_bib0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1748-717X-6-33","article-title":"Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose\u2013volume effects of pelvic radiotherapy","volume":"6","author":"Bratland","year":"2011","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.neulet.2015.12.012_bib0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2007.06.053","article-title":"Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity","volume":"149","author":"Chen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2015.12.012_bib0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.phrs.2010.01.011","article-title":"HDAC inhibitors and neurodegeneration: at the edge between protection and damage","volume":"62","author":"Dietz","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2015.12.012_bib0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/17482960802320487","article-title":"Phase 2 study of sodium phenylbutyrate in ALS","volume":"10","author":"Cudkowicz","year":"2009","journal-title":"Amyotroph Lateral Scler."},{"key":"10.1016\/j.neulet.2015.12.012_bib0200","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/MOP.0b013e3282f1884c","article-title":"Clinical trials in spinal muscular atrophy","volume":"19","author":"Darras","year":"2007","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.neulet.2015.12.012_bib0205","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.21620","article-title":"Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis","volume":"66","author":"Piepers","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2015.12.012_bib0210","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ana.24260","article-title":"Epigenetic therapy for Friedreich ataxia","volume":"76","author":"Soragni","year":"2014","journal-title":"Ann. Neurol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015303037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394015303037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T07:45:32Z","timestamp":1589615132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394015303037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":42,"alternative-id":["S0304394015303037"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2015.12.012","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2015.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}