{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:52:00Z","timestamp":1781830320489,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T00:00:00Z","timestamp":1488672000000},"content-version":"am","delay-in-days":338,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Center for Neuroscience and Regenerative Medicine (CNRM)"},{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009896","name":"U.S. Navy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Government"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.neulet.2016.02.041","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T12:42:06Z","timestamp":1456576926000},"page":"66-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["White matter microstructure of the uncinate fasciculus is associated with subthreshold posttraumatic stress disorder symptoms and fear potentiated startle during early extinction in recently deployed Service Members"],"prefix":"10.1016","volume":"618","author":[{"given":"Michelle E.","family":"Costanzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzung","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Leaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista B.","family":"Highland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth Davin","family":"Norrholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.02.041_bib0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.janxdis.2015.02.003","article-title":"The prevalence of posttraumatic stress disorder in Operation Enduring Freedom\/Operation Iraqi Freedom (OEF\/OIF) Veterans: a meta-analysis","volume":"31","author":"Fulton","year":"2015","journal-title":"J. Anxiety Disord."},{"issue":"1","key":"10.1016\/j.neulet.2016.02.041_bib0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0165-0327(02)00218-5","article-title":"Partial posttraumatic stress disorder revisited","volume":"78","author":"Mylle","year":"2004","journal-title":"J. Affect. Disord."},{"issue":"11","key":"10.1016\/j.neulet.2016.02.041_bib0015","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.biopsych.2012.06.002","article-title":"Early intervention may prevent the development of posttraumatic stress disorder: a randomized pilot civilian study with modified prolonged exposure","volume":"72","author":"Rothbaum","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2016.02.041_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fnbeh.2011.00044","article-title":"Neural mechanisms of impaired fear inhibition in posttraumatic stress disorder","volume":"5","author":"Jovanovic","year":"2011","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2016.02.041_bib0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cortex.2014.11.006","article-title":"Fear-potentiated startle during extinction is associated with white matter microstructure and functional connectivity","volume":"64","author":"Fani","year":"2015","journal-title":"Cortex"},{"issue":"7","key":"10.1016\/j.neulet.2016.02.041_bib0030","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopsych.2009.02.028","article-title":"Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder","volume":"66","author":"Phan","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.neulet.2016.02.041_bib0035","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archgenpsychiatry.2011.2178","article-title":"Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder","volume":"69","author":"Tromp","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"issue":"6","key":"10.1016\/j.neulet.2016.02.041_bib0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.biopsych.2010.09.013","article-title":"Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity","volume":"69","author":"Norrholm","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neulet.2016.02.041_bib0045","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/da.1029","article-title":"Clinician-administered PTSD scale: a review of the first ten years of research","volume":"13","author":"Weathers","year":"2001","journal-title":"Depress. Anxiety"},{"issue":"8","key":"10.1016\/j.neulet.2016.02.041_bib0050","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0005-7967(00)00084-X","article-title":"The validity of the PTSD checklist as a measure of symptomatic change in combat-related PTSD","volume":"39","author":"Forbes","year":"2001","journal-title":"Behav. Res. Ther."},{"issue":"18","key":"10.1016\/j.neulet.2016.02.041_bib0055","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1001\/jama.282.18.1737","article-title":"Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study: Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire","volume":"282","author":"Spitzer","year":"1999","journal-title":"JAMA"},{"issue":"2 pt 2","key":"10.1016\/j.neulet.2016.02.041_bib0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijpsycho.2014.11.005","article-title":"Fear load: the psychophysiological over-expression of fear as an intermediate phenotype associated with trauma reactions","volume":"98","author":"Norrholm","year":"2015","journal-title":"Int. J. Psychophysiol."},{"issue":"1","key":"10.1016\/j.neulet.2016.02.041_bib0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12021-012-9159-9","article-title":"System for integrated neuroimaging analysis and processing of structure","volume":"11","author":"Landman","year":"2013","journal-title":"Neuroinformatics"},{"issue":"2","key":"10.1016\/j.neulet.2016.02.041_bib0070","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuroimage.2011.06.020","article-title":"Direct segmentation of the major white matter tracts in diffusion tensor images","volume":"58","author":"Bazin","year":"2011","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neulet.2016.02.041_bib0075","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1176\/ajp.152.1.116","article-title":"Arousal, numbing, and intrusion: symptom structure of PTSD following assault","volume":"152","author":"Foa","year":"1995","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.neulet.2016.02.041_bib0080","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jts.2490100407","article-title":"Predictors of emotional numbing in posttraumatic stress disorder","volume":"10","author":"Litz","year":"1997","journal-title":"J. Trauma. Stress"},{"issue":"4","key":"10.1016\/j.neulet.2016.02.041_bib0085","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neubiorev.2006.11.010","article-title":"PTSD and stress sensitisation: a tale of brain and body part 1: human studies","volume":"31","author":"Stam","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.neulet.2016.02.041_bib0090","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1207\/S15374424JCCP3201_15","article-title":"A prospective test of the association between hyperarousal and emotional numbing in youth with a history of traumatic stress","volume":"32","author":"Weems","year":"2003","journal-title":"J. Clin. Child Adolesc. Psychol."},{"issue":"2","key":"10.1016\/j.neulet.2016.02.041_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1037\/0021-843X.113.2.189","article-title":"All symptoms are not created equal: the prominent role of hyperarousal in the natural course of posttraumatic psychological distress","volume":"113","author":"Schell","year":"2004","journal-title":"J. Abnorm. Psychol."},{"issue":"Pt 6","key":"10.1016\/j.neulet.2016.02.041_bib0100","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/brain\/awt094","article-title":"Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis","volume":"136","author":"Von Der Heide","year":"2013","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.neulet.2016.02.041_bib0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.biopsych.2009.08.023","article-title":"Aversive imagery in posttraumatic stress disorder: trauma recurrence, comorbidity, and physiological reactivity","volume":"67","author":"McTeague","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.neulet.2016.02.041_bib0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tics.2011.10.005","article-title":"Psychobiological allostasis: resistance, resilience and vulnerability","volume":"15","author":"Karatsoreos","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neulet.2016.02.041_bib0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2014.05.054","article-title":"Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging","volume":"577C","author":"Costanzo","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.neulet.2016.02.041_bib0120","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1038\/npp.2012.146","article-title":"White matter integrity in highly traumatized adults with and without post-traumatic stress disorder","volume":"37","author":"Fani","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2016.02.041_bib0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/da.22044","article-title":"White matter integrity and its relationship to PTSD and childhood trauma\u2014a systematic review and meta-analysis","volume":"30","author":"Daniels","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neulet.2016.02.041_bib0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnbeh.2013.00010","article-title":"Understanding resilience","volume":"7","author":"Wu","year":"2013","journal-title":"Front. Behav. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016301070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016301070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T01:27:04Z","timestamp":1689816424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016301070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":26,"alternative-id":["S0304394016301070"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.02.041","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter microstructure of the uncinate fasciculus is associated with subthreshold posttraumatic stress disorder symptoms and fear potentiated startle during early extinction in recently deployed Service Members","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}