{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:15:12Z","timestamp":1788581712783,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.neulet.2016.03.013","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T22:01:48Z","timestamp":1457560908000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Antimanic-like effects of (R)-(\u2212)-carvone and (S)-(+)-carvone in mice"],"prefix":"10.1016","volume":"619","author":[{"given":"Francianne P.","family":"Nogoceke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inara M.R.","family":"Barcaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e3o P.","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Andreatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.03.013_bib0005","series-title":"Manic-depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin","year":"2007"},{"key":"10.1016\/j.neulet.2016.03.013_bib0010","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1476-5381.2011.01318.x","article-title":"Predictive animal models of mania: hits, misses and future directions","volume":"164","author":"Young","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0015","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.neulet.2016.03.013_bib0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1017\/S1461145710001641","article-title":"Factors modifying drug and placebo responses in randomized trials for bipolar mania","volume":"14","author":"Yildiz","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2003.10.015","article-title":"Perspectives for the development of animal models of bipolar disorder: prog","volume":"28","author":"Machado-Vieira","year":"2004","journal-title":"Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4088\/PCC.9064su1c.04","article-title":"A critical appraisal of treatments for bipolar disorder","volume":"12","author":"Nierenberg","year":"2010","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0035","first-page":"3","article-title":"\u00d3leos essenciais com propriedades anticonvulsivantes","volume":"2","author":"de Almeida","year":"2003","journal-title":"Bol. Latinoam. Caribe Plantas Med. Aromat."},{"key":"10.1016\/j.neulet.2016.03.013_bib0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/chir.20379","article-title":"Influence of the chirality of (R)-(\u2212)-and (S)-(+)-carvone in the central nervous system: a comparative study","volume":"19","author":"de Sousa","year":"2007","journal-title":"Chirality"},{"key":"10.1016\/j.neulet.2016.03.013_bib0045","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1248\/bpb.31.1017","article-title":"Antinociceptive activity of (\u2212)-carvone: evidence of association with decreased peripheral nerve excitability","volume":"31","author":"Gon\u00e7alves","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2016.03.013_bib0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phymed.2009.10.006","article-title":"A multi-center double-blind, randomised study of the Lavender oil preparation silexan in comparison to lorazepam for generalized anxiety disorder","volume":"17","author":"Woelk","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neulet.2016.03.013_bib0055","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2010.07.027","article-title":"Distinct effects of carvone analogues on the isolated nerve of rats","volume":"645","author":"Gon\u00e7alves","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0060","doi-asserted-by":"crossref","first-page":"114512","DOI":"10.1063\/1.3693270","article-title":"The optical activity of carvone: a theoretical and experimental investigation","volume":"136","author":"Lambert","year":"2012","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.neulet.2016.03.013_bib0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fitote.2012.10.012","article-title":"(\u2212)-Carvone: antispasmodic effect and mode of action","volume":"85","author":"Souza","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.neulet.2016.03.013_bib0070","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1590\/S0100-879X2012007500021","article-title":"Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(\u2212)-carvone in the elevated T-maze","volume":"45","author":"Hatano","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neulet.2016.03.013_bib0075","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/ffj.1600","article-title":"R-(+)- and S-(\u2212)-carvone: influence of chirality on locomotion activity in mice","volume":"20","author":"Buchbauer","year":"2005","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.neulet.2016.03.013_bib0080","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10571-012-9812-8","article-title":"Anticonvulsant and antioxidant effects of cyano-carvone and its action on acetylcholinesterase activity in mice hippocampus","volume":"32","author":"Costa","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0085","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4034\/RBCS.2012.16.03.04","article-title":"Avalia\u00e7\u00e3o da toxicidade aguda e efeito ansiol\u00edtico de um derivado sint\u00e9tico da carvona","volume":"16","author":"Costa","year":"2012","journal-title":"Rev. Bras. Ci\u00eanc. Sa\u00fade"},{"key":"10.1016\/j.neulet.2016.03.013_bib0090","first-page":"966","article-title":"A.L. dos Reis Barbosa, T.C., LIma, D.P. de Sousa, R.M. de Freitas, Cyane-carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows antinociceptive effect in mice","volume":"37","author":"Marques","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.neulet.2016.03.013_bib0095","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pbb.2014.06.016","article-title":"Anticonvulsant effects of acute treatment with cyane-carvone at repeated oral doses in epilepsy models","volume":"124","author":"Marques","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2016.03.013_bib0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1590\/S0102-695X2007000200006","article-title":"Pharmacological effects of the monoterpene \u03b1, \u03b2-epoxy-carvone in mice","volume":"17","author":"de Sousa","year":"2007","journal-title":"Braz. J. Pharmacogn."},{"key":"10.1016\/j.neulet.2016.03.013_bib0105","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11418-012-0738-8","article-title":"Antinociceptive and anti-inflammatory effects of the monoterpene \u03b1,\u03b2-epoxy-carvone in mice","volume":"67","author":"da Rocha","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.neulet.2016.03.013_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2008.07.037","article-title":"Anticonvulsant effect of a natural compound \u03b1,\u03b2-epoxy-carvone and its action on the nerve excitability","volume":"443","author":"de Almeida","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2016.03.013_bib0115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1248\/bpb.29.811","article-title":"Evaluation of the central activity of hydroxydihydrocarvone","volume":"29","author":"de Sousa","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2016.03.013_bib0120","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.pnpbp.2008.09.023","article-title":"The antimanic-like effect of tamoxifen: behavioural comparison with other PKC-inhibiting and antiestrogenic drugs","volume":"32","author":"Sabioni","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2011.06.012","article-title":"Antimanic-like effect of tamoxifen is not reproduced by acute or chronic administration of medroxyprogesterone or clomiphene","volume":"500","author":"Pereira","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2016.03.013_bib0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1755-5949.2010.00224.x","article-title":"Successful combined therapy with tamoxifen and lithium in a paradoxical sleep deprivation-induced mania model","volume":"18","author":"Armani","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neulet.2016.03.013_bib0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0924-977X(95)00023-I","article-title":"Sleep deprivation in the rat: an animal model of mania","volume":"5","author":"Gessa","year":"1995","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0140","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/0269881106060241","article-title":"Modelling facets of mania: new directions related to the notion of endophenotypes","volume":"20","author":"Einat","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0145","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s11064-015-1575-4","article-title":"Effects of mood stabilizers on brain energy metabolism in mice submitted to an animal model of mania induced by paradoxical sleep deprivation","volume":"40","author":"Streck","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2016.03.013_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyu031","article-title":"Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania","volume":"18","author":"Abrial","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0155","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pnpbp.2012.11.015","article-title":"Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats","volume":"43","author":"Abrial","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00318-1","article-title":"Differential sensitivity to lithium\u2019s reversal of amphetamine-induced open-field activity in two inbred strains of mice","volume":"118","author":"Gould","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2016.03.013_bib0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1734-1140(11)70399-1","article-title":"Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania","volume":"63","author":"Barbosa","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neulet.2016.03.013_bib0170","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/fcp.12022","article-title":"The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels","volume":"27","author":"Tonelli","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0175","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12011-014-0067-8","article-title":"Combination of omega-3 fatty acids lithium, and aripiprazole reduces oxidative stress in brain of mice with mania","volume":"160","author":"Arunagiri","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.neulet.2016.03.013_bib0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/neu.2013.23","article-title":"Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice","volume":"26","author":"Kara","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.neulet.2016.03.013_bib0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/FBP.0000000000000128","article-title":"The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors","volume":"26","author":"Ene","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2015.07.027","article-title":"Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors","volume":"603","author":"Zhou","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2016.03.013_bib0195","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0165-1781(99)00036-0","article-title":"Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression","volume":"86","author":"Colombo","year":"1999","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2016.03.013_bib0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2004.10.026","article-title":"Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids","volume":"506","author":"Hall","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2016.03.013_bib0205","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.mp.4001518","article-title":"Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers","volume":"9","author":"Gould","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0210","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.2174\/138945009789735138","article-title":"The role of sodium channels in the mechanism of action of antidepressants and mood stabilizers","volume":"10","author":"Bourin","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neulet.2016.03.013_bib0215","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0165-0327(84)90018-1","article-title":"Plasma GABA levels in psychiatric illness","volume":"6","author":"Petty","year":"1984","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neulet.2016.03.013_bib0220","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/bdi.12074","article-title":"Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder","volume":"15","author":"Brady","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neulet.2016.03.013_bib0225","first-page":"29","article-title":"Clonazepam in acute and maintenance treatment of bipolar affective disorder","author":"Chouinard","year":"1987","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0230","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3109\/00048679109077740","article-title":"Clonazepam in acute mania: a double blind trial","volume":"25","author":"Edwards","year":"1991","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"Suppl. 4","key":"10.1016\/j.neulet.2016.03.013_bib0235","first-page":"114","article-title":"A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms","volume":"38","author":"Chouinard","year":"1993","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.neulet.2016.03.013_bib0240","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/chir.22328","article-title":"Inhibitory effects of carvone isomers on the GABAA receptor in primary cultures of rat cortical neurons","volume":"26","author":"S\u00e1nchez-Borzone","year":"2014","journal-title":"Chirality"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016301446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016301446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T05:54:44Z","timestamp":1566453284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016301446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":48,"alternative-id":["S0304394016301446"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.03.013","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimanic-like effects of (R)-(\u2212)-carvone and (S)-(+)-carvone in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}