{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:42Z","timestamp":1790680902483,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471309"],"award-info":[{"award-number":["81471309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371406"],"award-info":[{"award-number":["81371406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571245"],"award-info":[{"award-number":["81571245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501103"],"award-info":[{"award-number":["81501103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Provincial Outstanding Medical Academic Professional Program"},{"name":"Qingdao Key Health Discipline Development Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.neulet.2016.04.020","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T14:03:58Z","timestamp":1460383438000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Common variant in PTK2B is associated with late-onset Alzheimer\u2019s disease: A replication study and meta-analyses"],"prefix":"10.1016","volume":"621","author":[{"given":"Ya-Qing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Shan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Li","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.04.020_bib0005","article-title":"Dissecting the contribution of vascular alterations and aging to alzheimer's disease","author":"Janota","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2016.04.020_bib0010","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2016.04.020_bib0015","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2016.04.020_bib0020","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.neulet.2016.04.020_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/B978-0-12-800149-3.00005-6","article-title":"Genetics of Alzheimer's disease","volume":"87","author":"Chouraki","year":"2014","journal-title":"Adv. Genet."},{"key":"10.1016\/j.neulet.2016.04.020_bib0030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3233\/JAD-140729","article-title":"Genetic determinants of disease progression in Alzheimer's disease","volume":"43","author":"Wang","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2016.04.020_bib0035","doi-asserted-by":"crossref","first-page":"e1004606","DOI":"10.1371\/journal.pgen.1004606","article-title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias","volume":"10","author":"Beecham","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neulet.2016.04.020_bib0040","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/376737a0","article-title":"Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions","volume":"376","author":"Lev","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2016.04.020_bib0045","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1523\/JNEUROSCI.22-13-05452.2002","article-title":"Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2\/Src-family kinase pathway in cortical neurons","volume":"22","author":"Heidinger","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.04.020_bib0050","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1111\/j.1471-4159.2006.04075.x","article-title":"Reduced NMDA receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPalpha in NMDA receptor regulation","volume":"98","author":"Le","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2016.04.020_bib0055","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2016.04.020_bib0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exger.2014.01.013","article-title":"Association of LRRTM3 polymorphisms with late-onset Alzheimer\u2019s disease in Han Chinese","volume":"52","author":"Wang","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neulet.2016.04.020_bib0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jns.2010.09.027","article-title":"Genetic association of PICALM polymorphisms with Alzheimer\u2019s disease in Han Chinese","volume":"300","author":"Yu","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2016.04.020_bib0070","doi-asserted-by":"crossref","first-page":"e1001308","DOI":"10.1371\/journal.pgen.1001308","article-title":"Genome-wide association of familial late-onset Alzheimer\u2019s disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE","volume":"7","author":"Wijsman","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neulet.2016.04.020_bib0075","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/gepi.20217","article-title":"Genetic model testing and statistical power in population-based association studies of quantitative traits","volume":"31","author":"Lettre","year":"2007","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.neulet.2016.04.020_bib0080","doi-asserted-by":"crossref","first-page":"e0144898","DOI":"10.1371\/journal.pone.0144898","article-title":"Polygenic analysis of late-onset Alzheimer\u2019s disease from mainland China","volume":"10","author":"Jiao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2016.04.020_bib0085","doi-asserted-by":"crossref","first-page":"36955","DOI":"10.18632\/oncotarget.6271","article-title":"Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population","volume":"6","author":"Xiao","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.neulet.2016.04.020_bib0090","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1038\/tp.2014.2","article-title":"Follow-up of loci from the International Genomics of Alzheimer\u2019s Disease Project identifies TRIP4 as a novel susceptibility gene","volume":"4","author":"Ruiz","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neulet.2016.04.020_bib0095","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neulet.2016.04.020_bib0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2012.01.067","article-title":"SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer\u2019s disease in a Northern Han Chinese population","volume":"1448","author":"Wang","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2016.04.020_bib0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00702-013-1106-x","article-title":"TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer\u2019s disease in Han Chinese","volume":"121","author":"Lu","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neulet.2016.04.020_bib0110","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.96.26.15233","article-title":"Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer\u2019s disease","volume":"96","author":"Bales","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2016.04.020_bib0115","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ana.24394","article-title":"Fyn inhibition rescues established memory and synapse loss in Alzheimer mice","volume":"77","author":"Kaufman","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2016.04.020_bib0120","doi-asserted-by":"crossref","first-page":"e95152","DOI":"10.1371\/journal.pone.0095152","article-title":"Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings","volume":"9","author":"Rosenthal","year":"2014","journal-title":"PLoS One"}],"updated-by":[{"DOI":"10.1016\/j.neulet.2016.05.023","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000}}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016302257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016302257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:20:03Z","timestamp":1759609203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016302257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":24,"alternative-id":["S0304394016302257"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.04.020","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Common variant in PTK2B is associated with late-onset Alzheimer\u2019s disease: A replication study and meta-analyses","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}