{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:25:55Z","timestamp":1786994755621,"version":"build-2736575974"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008731","name":"Association Europ\u00e9enne contre les Leucodystrophies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS38236"],"award-info":[{"award-number":["NS38236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.neulet.2016.05.028","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T20:46:03Z","timestamp":1463517963000},"page":"222-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Novel pathologic findings in patients with Pelizaeus-Merzbacher disease"],"prefix":"10.1016","volume":"627","author":[{"given":"Jeremy J.","family":"Laukka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kamholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Bessert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Skoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.05.028_bib0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1750-3639.2006.00043.x","article-title":"Extensive cortical remyelination in patients with chronic multiple sclerosis","volume":"17","author":"Albert","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/glia.22591","article-title":"Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate","volume":"62","author":"Appikatla","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2016.05.028_bib0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ana.410360115","article-title":"Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis","volume":"36","author":"Arnold","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0020","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jnr.490420602","article-title":"Widespread expression of the peripheral myelin protein-22 gene (PMP22) in neural and non-neural tissues during murine development","volume":"42","author":"Baechner","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2016.05.028_bib0025","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1046\/j.1471-4159.2001.00116.x","article-title":"Chemical deacylation reduces the adhesive properties of proteolipid protein and leads to decompaction of the myelin sheath","volume":"76","author":"Bizzozero","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2016.05.028_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0022-510X(02)00069-2","article-title":"Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease","volume":"206","author":"Bjartmar","year":"2003","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0035","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1523\/JNEUROSCI.15-08-05502.1995","article-title":"Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths","volume":"15","author":"Boison","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0040","doi-asserted-by":"crossref","first-page":"11709","DOI":"10.1073\/pnas.91.24.11709","article-title":"Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice","volume":"91","author":"Boison","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2016.05.028_bib0045","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1023\/A:1019697506757","article-title":"Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways","volume":"30","author":"Cerghet","year":"2001","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0050","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1523\/JNEUROSCI.1336-13.2013","article-title":"Gait abnormalities and progressive myelin degeneration in a new murine model of Pelizaeus-Merzbacher disease with tandem genomic duplication","volume":"33","author":"Clark","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0055","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/brain\/121.8.1469","article-title":"Axonal damage correlates with disability in patients with relapsing- remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study","volume":"121","author":"De Stefano","year":"1998","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0060","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.49.4.1138","article-title":"Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient","volume":"49","author":"De Stefano","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2016.05.028_bib0065","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/glia.440020303","article-title":"Myelination in the jimpy mouse in the absence of proteolipid protein","volume":"2","author":"Duncan","year":"1989","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2016.05.028_bib0070","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuroimage.2010.03.013","article-title":"The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models","volume":"51","author":"Dyakin","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neulet.2016.05.028_bib0075","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/brain\/awh417","article-title":"Inflammation stimulates remyelination in areas of chronic demyelination","volume":"128","author":"Foote","year":"2005","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/brain\/121.1.103","article-title":"Imaging axonal damage of normal-appearing white matter in multiple sclerosis","volume":"121","author":"Fu","year":"1998","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0085","doi-asserted-by":"crossref","first-page":"18402","DOI":"10.1523\/JNEUROSCI.2381-13.2013","article-title":"Signaling through ERK1\/2 controls myelin thickness during myelin repair in the adult central nervous system","volume":"33","author":"Fyffe-Maricich","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0090","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1749-6632.1999.tb08597.x","article-title":"Peripheral neuropathy caused by proteolipid protein gene mutations","volume":"883","author":"Garbern","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0095","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/brain\/awf043","article-title":"Patients lacking the major CNS myelin protein proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation","volume":"125","author":"Garbern","year":"2002","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.54.1.15","article-title":"Total brain N-acetylaspartate: a new measure of disease load in MS","volume":"54","author":"Gonen","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2016.05.028_bib0105","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1083\/jcb.140.4.925","article-title":"Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease","volume":"140","author":"Gow","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2990.1995.tb01036.x","article-title":"A case of Pelizaeus-Merzbacher disease showing increased dosage of the proteolipid protein gene","volume":"21","author":"Harding","year":"1995","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0115","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1073\/pnas.79.13.4217","article-title":"Development and maturation of central nervous system myelin: comparison of immunohistochemical localization of proteolipid protein and basic protein in myelin and oligodendrocytes","volume":"79","author":"Hartman","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neulet.2016.05.028_bib0120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.10320","article-title":"A PLP splicing abnormality is associated with an unusual presentation of PMD","volume":"52","author":"Hobson","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0125","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/1531-8249(199905)45:5<624::AID-ANA11>3.0.CO;2-1","article-title":"Proteolipid protein gene duplications causing Pelizaeus-Merzbacher disease: molecular mechanism and phenotypic manifestations","volume":"45","author":"Inoue","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0130","first-page":"32","article-title":"A duplicated PLP gene causing Pelizaeus-Merzbacher disease detected by comparative multiplex PCR","volume":"59","author":"Inoue","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0135","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0887-8994(88)90041-0","article-title":"Histopathologic and biochemical analysis of classic Pelizaeus- Merzbacher disease","volume":"4","author":"Iyoda","year":"1988","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0140","doi-asserted-by":"crossref","first-page":"e1002107","DOI":"10.1371\/journal.pbio.1002107","article-title":"The polarity protein Scribble regulates myelination and remyelination in the central nervous system","volume":"13","author":"Jarjour","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0896-6273(01)80046-5","article-title":"Assembly of CNS myelin in the absence of proteolipid protein","volume":"18","author":"Klugmann","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2016.05.028_bib0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00684566","article-title":"An autopsy case of classical Pelizaeus-Merzbacher's disease","volume":"31","author":"Konishi","year":"1975","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0155","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/jnr.23458","article-title":"Diffusion tensor imaging of patients with proteolipid protein 1 gene mutations","volume":"92","author":"Laukka","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2016.05.028_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02893591","article-title":"Eine eigenarige famili\u00e4r-hereditare Erkrankungsform (Aplasia axialis extra-corticalis congenita)","volume":"3","author":"Merzbacher","year":"1910","journal-title":"Zeitschrift f\u00fcr gesamte Neurologie und Psychiatrie"},{"key":"10.1016\/j.neulet.2016.05.028_bib0165","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1086\/302483","volume":"65","author":"Mimault","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s100380050072","article-title":"Connatal Pelizaeus-Merzbacher disease: a missense mutation in exon 4 of the proteolipid protein (PLP) gene","volume":"43","author":"Nagao","year":"1998","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0175","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1523\/JNEUROSCI.0232-09.2009","article-title":"Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination","volume":"29","author":"Narayanan","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.05.028_bib0180","first-page":"65","article-title":"Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice","volume":"5","author":"Nave","year":"1989","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0185","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/BF02057569","article-title":"\u00dcber eine eigenth\u00fcmliche form spastischer L\u00e4hmung mit cerebralerschinungen auf heredit\u00e4rer grundlage (Multiple sklerose)","volume":"16","author":"Pelizaeus","year":"1885","journal-title":"Arch. Psychiatr. Nervenkr."},{"key":"10.1016\/j.neulet.2016.05.028_bib0190","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/hmg\/2.4.465","article-title":"Pelizaeus-Merzbacher disease: a frameshift deletion\/insertion event in the myelin proteolipid gene","volume":"2","author":"Pham-Dinh","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0195","first-page":"34","article-title":"Neuronal system degeneration in Pelizaeus-Merzbacher disease with PLP1 gene duplication","volume":"61","author":"Pierson","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0200","first-page":"1355","article-title":"Complete deletion of the proteolipid protein gene (PLP) in a family with X-linked Pelizaeus-Merzbacher disease","volume":"49","author":"Raskind","year":"1991","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0205","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/glia.20370","article-title":"Subtle myelin defects in PLP-null mice","volume":"54","author":"Rosenbluth","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2016.05.028_bib0210","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/(SICI)1096-9861(19960722)371:2<336::AID-CNE12>3.0.CO;2-Q","article-title":"Myelin structure in proteolipid protein (PLP)-null mouse spinal cord","volume":"371","author":"Rosenbluth","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0215","doi-asserted-by":"crossref","DOI":"10.1177\/1759091414551955","article-title":"A new model of cuprizone-mediated demyelination\/remyelination","volume":"6","author":"Sachs","year":"2014","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neulet.2016.05.028_bib0220","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ng0394-257","article-title":"X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus","volume":"6","author":"Saugier-Veber","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0225","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1750-3639.1995.tb00603.x","article-title":"Neuropathology and genetics of Pelizaeus-Merzbacher disease","volume":"5","author":"Seitelberger","year":"1995","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0230","first-page":"150","article-title":"Pelizaeus-Merzbacher disease","volume":"vol. 10","author":"Seitelberger","year":"1970"},{"key":"10.1016\/j.neulet.2016.05.028_bib0235","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2008-1052382","article-title":"Structural manifestations of leukodystrophies","volume":"15","author":"Seitelberger","year":"1984","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neulet.2016.05.028_bib0240","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00401-009-0562-8","article-title":"Neuronal loss in Pelizaeus-Merzbacher disease differs in various mutations of the proteolipid protein 1","volume":"118","author":"Sima","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0245","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1212\/WNL.50.6.1749","article-title":"Duplication of the proteolipid protein gene is the major cause of Pelizaeus-Merzbacher disease","volume":"50","author":"Sistermans","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2016.05.028_bib0250","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0896-6273(02)01045-0","article-title":"The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher Disease","volume":"36","author":"Southwood","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2016.05.028_bib0255","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1093\/brain\/awq257","article-title":"Magnetic resonance imaging pattern recognition in hypomyelinating disorders","volume":"133","author":"Steenweg","year":"2016","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0260","doi-asserted-by":"crossref","first-page":"e00043","DOI":"10.1042\/AN20100016","article-title":"Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain","volume":"2","author":"Tatar","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neulet.2016.05.028_bib0265","first-page":"871","article-title":"Deletion of the proteolipid protein gene (PLP) in a patient with Pelizaeus-Merzbacher disease","volume":"69","author":"Thurston","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0270","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/ped.12450","article-title":"Pelizaeus-Merzbacher disease: cellular pathogenesis and pharmacologic therapy","volume":"56","author":"Torii","year":"2014","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.neulet.2016.05.028_bib0275","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.braindev.2012.02.006","article-title":"Clinical and genetic characterization of a 2-year-old boy with complete PLP1 deletion","volume":"34","author":"Torisu","year":"2012","journal-title":"Brain Dev."},{"key":"10.1016\/j.neulet.2016.05.028_bib0280","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","article-title":"Axonal transection in the lesions of multiple sclerosis","volume":"338","author":"Trapp","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2016.05.028_bib0285","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00019052-199906000-00008","article-title":"Axonal pathology in multiple sclerosis: relationship to neurologic disability","volume":"12","author":"Trapp","year":"1999","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0290","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1073\/pnas.86.23.9427","article-title":"Pelizaeus-Merzbacher disease: tight linkage to proteolipid protein gene exon variant","volume":"86","author":"Trofatter","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2016.05.028_bib0295","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00688701","article-title":"Seitelberger\u2019s connatal form of Pelizaeus-Merzbacher disease. Case report clinical, pathological and biochemical findings","volume":"40","author":"Ulrich","year":"1977","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0300","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0028-1091477","article-title":"Congenital Pelizaeus-Merzbacher disease (Seitelberger type), malformation and cystic degeneration of the central nervous system","volume":"9","author":"Vuia","year":"1978","journal-title":"Neuropadiatrie"},{"key":"10.1016\/j.neulet.2016.05.028_bib0305","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00005072-196904000-00005","article-title":"Absence of cerebral myelin sheaths in a case of presumed Pelizaeus-Merzbacher disease. Electron microscopic and biochemical studies","volume":"28","author":"Watanabe","year":"1969","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0310","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archneur.1977.00500220019003","article-title":"Conduction in myelinated, unmyelinated, and demyelinated fibers","volume":"34","author":"Waxman","year":"1977","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0315","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/brain\/awh409","article-title":"Three or more copies of the proteolipid protein gene PLP1 cause severe Pelizaeus-Merzbacher disease","volume":"128","author":"Wolf","year":"2005","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neulet.2016.05.028_bib0320","first-page":"A394","article-title":"Variation in PLP gene duplications causing Pelizaeus-Merzbacher disease","volume":"63","author":"Woodward","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0325","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1017\/S1462399408000677","article-title":"The molecular and cellular defects underlying Pelizaeus-Merzbacher disease","volume":"10","author":"Woodward","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.neulet.2016.05.028_bib0330","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/(SICI)1096-8628(19980203)75:4<439::AID-AJMG19>3.0.CO;2-P","article-title":"Jimpymsd mouse mutation and connatal pelizaeus-Merzbacher disease","volume":"75","author":"Yamamoto","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neulet.2016.05.028_bib0335","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00005072-196404000-00008","article-title":"Pelizaeus-Merzbacher disease: a study in nosology","volume":"23","author":"Zeman","year":"1964","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"April (2)","key":"10.1016\/j.neulet.2016.05.028_bib0340","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00005072-197304000-00010","article-title":"Early lesion of Pelizaeus-Merzbacher disease: electron microscopic and biochemical study","volume":"32","author":"Watanabe","year":"1973","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016303408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016303408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:28:37Z","timestamp":1771954117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016303408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":68,"alternative-id":["S0304394016303408"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.05.028","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel pathologic findings in patients with Pelizaeus-Merzbacher disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}