{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:46:07Z","timestamp":1769049967920,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.neulet.2016.07.045","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T12:44:49Z","timestamp":1469537089000},"page":"183-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Amyloid binding properties of curcumin analogues in Alzheimer\u2019s disease postmortem brain tissue"],"prefix":"10.1016","volume":"630","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-8400","authenticated-orcid":false,"given":"Emma R.","family":"Veldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisheng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Halldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie M.","family":"Svedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.07.045_bib0005","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neuroscience.2010.05.078","article-title":"Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease","volume":"169","author":"Ahmed","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2016.07.045_bib0010","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.neulet.2016.07.045_bib0015","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1021\/jf0603533","article-title":"Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease","volume":"54","author":"Balasubramanian","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)","volume":"9","author":"Chainani-Wu","year":"2003","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.neulet.2016.07.045_bib0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2967\/jnumed.111.094029","article-title":"Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand","volume":"53","author":"Csel\u00e9nyi","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.neulet.2016.07.045_bib0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jinorgbio.2003.10.014","article-title":"Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain","volume":"98","author":"Daniel","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-4274(98)00035-6","article-title":"Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats","volume":"95","author":"Deshpande","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neulet.2016.07.045_bib0040","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00259-012-2322-6","article-title":"Low background and high contrast PET imaging of amyloid-beta with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients","volume":"40","author":"Forsberg","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neulet.2016.07.045_bib0045","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1471-4159.2007.04613.x","article-title":"Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model","volume":"102","author":"Garcia-Alloza","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0050","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0197-4580(02)00042-8","article-title":"Testing times for the amyloid cascade hypothesis","volume":"23","author":"Hardy","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2016.07.045_bib0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/pr.110.004044","article-title":"The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer","volume":"66","author":"Heger","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neulet.2016.07.045_bib0060","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1471-4159.2008.05861.x","article-title":"AZD2184: a radioligand for sensitive detection of beta-amyloid deposits","volume":"108","author":"Johnson","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0065","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1471-4159.2010.06812.x","article-title":"Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand","volume":"114","author":"Jur\u00e9us","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00280-006-0355-x","article-title":"Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine","volume":"60","author":"Marczylo","year":"2006","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0080","doi-asserted-by":"crossref","first-page":"a006262","DOI":"10.1101\/cshperspect.a006262","article-title":"Biochemistry of amyloid beta-protein and amyloid deposits in Alzheimer disease","volume":"2","author":"Masters","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neulet.2016.07.045_bib0085","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2016.07.045_bib0090","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.bmc.2011.08.052","article-title":"Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid beta-protein fibrils","volume":"19","author":"Masuda","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0095","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2016.07.045_bib0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0105","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/NEN.0b013e3181d709eb","article-title":"Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples","volume":"69","author":"Mohorko","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1292\/jvms.11-0307","article-title":"Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain","volume":"74","author":"Mutsuga","year":"2012","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.neulet.2016.07.045_bib0115","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0120","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jnr.20025","article-title":"Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro","volume":"75","author":"Ono","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2016.07.045_bib0125","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1747-0285.2007.00557.x","article-title":"Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility","volume":"70","author":"Reinke","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.neulet.2016.07.045_bib0130","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1176\/ajp.139.9.1136","article-title":"The Global Deterioration Scale for assessment of primary degenerative dementia","volume":"139","author":"Reisberg","year":"1982","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2016.07.045_bib0135","doi-asserted-by":"crossref","first-page":"10759","DOI":"10.1038\/ncomms10759","article-title":"Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease","volume":"7","author":"Sehlin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2016.07.045_bib0140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1196\/annals.1352.010","article-title":"Curcumin: getting back to the roots","volume":"1056","author":"Shishodia","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2016.07.045_bib0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.neuint.2008.12.016","article-title":"[11C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients","volume":"54","author":"Svedberg","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2016.07.045_bib0150","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.nucmedbio.2011.10.007","article-title":"Preclinical studies of potential amyloid binding PET\/SPECT ligands in Alzheimer's disease","volume":"39","author":"Svedberg","year":"2012","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.neulet.2016.07.045_bib0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-12-385883-2.00012-6","article-title":"Alzheimer's disease and the amyloid beta-protein","volume":"107","author":"Walsh","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.neulet.2016.07.045_bib0160","article-title":"Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease","author":"Venigalla","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2016.07.045_bib0165","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1016\/j.biomaterials.2010.01.142","article-title":"Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease","volume":"31","author":"Yanagisawa","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.neulet.2016.07.045_bib0170","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2016.07.045_bib0175","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1021\/bi802046n","article-title":"Structural characterization of a soluble amyloid beta-peptide oligomer","volume":"48","author":"Yu","year":"2009","journal-title":"Biochemistry"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016305390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016305390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T02:04:29Z","timestamp":1589681069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016305390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"alternative-id":["S0304394016305390"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.07.045","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid binding properties of curcumin analogues in Alzheimer\u2019s disease postmortem brain tissue","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.07.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}