{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:59:14Z","timestamp":1792144754424,"version":"4.4.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.neulet.2016.10.003","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T11:10:20Z","timestamp":1475925020000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"special_numbering":"C","title":["Duration of untreated illness as a key to early intervention in schizophrenia: A review"],"prefix":"10.1016","volume":"669","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-4420","authenticated-orcid":false,"given":"Andrea","family":"Murru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Carpiniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.10.003_bib0005","series-title":"DSM-5: Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"issue":"November (9904)","key":"10.1016\/j.neulet.2016.10.003_bib0010","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010","volume":"382","author":"Whiteford","year":"2013","journal-title":"Lancet"},{"issue":"September (9)","key":"10.1016\/j.neulet.2016.10.003_bib0015","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Wittchen","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"January (2)","key":"10.1016\/j.neulet.2016.10.003_bib0020","doi-asserted-by":"crossref","first-page":"e0116820","DOI":"10.1371\/journal.pone.0116820","article-title":"The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010","volume":"10","author":"Whiteford","year":"2015","journal-title":"PLoS One"},{"issue":"August (8)","key":"10.1016\/j.neulet.2016.10.003_bib0025","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1017\/S0033291708003449","article-title":"The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis","volume":"38","author":"Jeppesen","year":"2008","journal-title":"Psychol. Med."},{"issue":"33","key":"10.1016\/j.neulet.2016.10.003_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1192\/S0007125000297663","article-title":"Early intervention in psychosis. The critical period hypothesis","volume":"172","author":"Birchwood","year":"1998","journal-title":"Br. J. Psychiatry Suppl."},{"issue":"January (2)","key":"10.1016\/j.neulet.2016.10.003_bib0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/schbul\/22.2.241","article-title":"First-episode schizophrenia: I. Early course parameters","volume":"22","author":"Larsen","year":"1996","journal-title":"Schizophr. Bull."},{"issue":"August","key":"10.1016\/j.neulet.2016.10.003_bib0040","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1192\/bjp.157.2.182","article-title":"Further investigation of the predictors of outcome following first schizophrenic episodes","volume":"157","author":"Johnstone","year":"1990","journal-title":"Br. J. Psychiatry"},{"issue":"November (4)","key":"10.1016\/j.neulet.2016.10.003_bib0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/eip.12016","article-title":"Differences in latency to first pharmacological treatment (duration of untreated illness) in anxiety disorders: a study on patients with panic disorder, generalized anxiety disorder and obsessive-compulsive disorder","volume":"7","author":"Dell\u2019Osso","year":"2013","journal-title":"Early Interv. Psychiatry"},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0050","article-title":"Reduced duration of untreated illness over time in patients with schizophrenia spectrum, mood and anxiety disorders","author":"Dell\u2019Osso","year":"2016","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"March (3)","key":"10.1016\/j.neulet.2016.10.003_bib0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00127-007-0287-8","article-title":"Mental health laws that require dangerousness for involuntary admission may delay the initial treatment of schizophrenia","volume":"43","author":"Large","year":"2008","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"November (11)","key":"10.1016\/j.neulet.2016.10.003_bib0060","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1176\/appi.ps.661103","article-title":"Mental health laws influence the duration of untreated psychosis","volume":"66","author":"Nielssen","year":"2015","journal-title":"Psychiatr. Serv."},{"issue":"April (4)","key":"10.1016\/j.neulet.2016.10.003_bib0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1017\/S1092852900000079","article-title":"Duration of untreated psychosis and duration of untreated illness: new vistas","volume":"15","author":"Dell\u2019osso","year":"2010","journal-title":"CNS Spectr."},{"issue":"May (3)","key":"10.1016\/j.neulet.2016.10.003_bib0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/YIC.0b013e3283384c74","article-title":"Age at onset and latency to treatment (duration of untreated illness) in patients with mood and anxiety disorders: a naturalistic study","volume":"25","author":"Altamura","year":"2010","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"August (5)","key":"10.1016\/j.neulet.2016.10.003_bib0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00406-009-0085-2","article-title":"Duration of untreated illness and suicide in bipolar disorder: a naturalistic study","volume":"260","author":"Altamura","year":"2010","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1744-859X-11-21","article-title":"Does duration of untreated psychosis predict very long term outcome of schizophrenic disorders? Results of a retrospective study","volume":"11","author":"Primavera","year":"2012","journal-title":"Ann. Gen. Psychiatry"},{"issue":"February (1)","key":"10.1016\/j.neulet.2016.10.003_bib0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jad.2012.07.008","article-title":"The effect of prolonged duration of untreated depression on antidepressant treatment outcome","volume":"145","author":"Bukh","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/YIC.0000000000000049","article-title":"Factors characterizing access and latency to first pharmacological treatment in Italian patients with schizophrenia, mood, and anxiety spectrum disorders","volume":"30","author":"Dell\u2019Osso","year":"2015","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"December","key":"10.1016\/j.neulet.2016.10.003_bib0095","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jad.2015.09.009","article-title":"The role of comorbidities in duration of untreated illness for bipolar spectrum disorders","volume":"188","author":"Murru","year":"2015","journal-title":"J. Affect. Disord."},{"issue":"September (9)","key":"10.1016\/j.neulet.2016.10.003_bib0100","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archpsyc.62.9.975","article-title":"Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review","volume":"62","author":"Marshall","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000338608","article-title":"Can long-term outcomes be improved by shortening the duration of untreated illness in psychiatric disorders? A conceptual framework","volume":"46","author":"Dell\u2019Osso","year":"2013","journal-title":"Psychopathology"},{"issue":"August","key":"10.1016\/j.neulet.2016.10.003_bib0110","doi-asserted-by":"crossref","first-page":"s58","DOI":"10.1192\/bjp.191.50.s58","article-title":"Outcome measures in early psychosis; relevance of duration of untreated psychosis","volume":"50","author":"Singh","year":"2007","journal-title":"Br. J. Psychiatry Suppl."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.31887\/DCNS.2005.7.1\/jvanos","article-title":"Toward a world consensus on prevention of schizophrenia","volume":"7","author":"Van Os","year":"2005","journal-title":"Dialogues Clin. Neurosci."},{"issue":"November (11)","key":"10.1016\/j.neulet.2016.10.003_bib0120","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/archpsyc.1996.01830110060007","article-title":"Lifetime prevalence, demographic risk factors, and diagnostic validity of nonaffective psychosis as assessed in a US community sample. The National Comorbidity Survey","volume":"53","author":"Kendler","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S0033291797005667","article-title":"A survey of delusional ideation in primary-care patients","volume":"28","author":"Verdoux","year":"1998","journal-title":"Psychol. Med."},{"issue":"November (11)","key":"10.1016\/j.neulet.2016.10.003_bib0130","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpsyc.57.11.1053","article-title":"Children\u2019s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study","volume":"57","author":"Poulton","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"issue":"January (2)","key":"10.1016\/j.neulet.2016.10.003_bib0135","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/oxfordjournals.schbul.a007010","article-title":"When does experience of psychosis result in a need for care? A prospective general population study","volume":"29","author":"Bak","year":"2003","journal-title":"Schizophr. Bull."},{"issue":"April (3)","key":"10.1016\/j.neulet.2016.10.003_bib0140","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S0033291701003488","article-title":"Duration of untreated psychosis: a critical examination of the concept and its importance","volume":"31","author":"Norman","year":"2001","journal-title":"Psychol. Med."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1176\/ajp.157.1.60","article-title":"Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series?","volume":"157","author":"Craig","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0150","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1176\/appi.ajp.160.1.142","article-title":"Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia","volume":"160","author":"Ho","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"November (11)","key":"10.1016\/j.neulet.2016.10.003_bib0155","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.4088\/JCP.09m05841yel","article-title":"The \u2018doses\u2019 of initial, untreated hallucinations and delusions: a proof-of-concept study of enhanced predictors of first-episode symptomatology and functioning relative to duration of untreated psychosis","volume":"72","author":"Compton","year":"2011","journal-title":"J. Clin. Psychiatry"},{"issue":"November (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.schres.2012.08.013","article-title":"Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years","volume":"141","author":"Hill","year":"2012","journal-title":"Schizophr. Res."},{"issue":"September (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(99)00169-3","article-title":"Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis","volume":"45","author":"Larsen","year":"2000","journal-title":"Schizophr. Res."},{"issue":"November (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.schres.2013.07.014","article-title":"Association of prominent positive and prominent negative symptoms and functional health, well-being, healthcare-related quality of life and family burden: a CATIE analysis","volume":"150","author":"Rabinowitz","year":"2013","journal-title":"Schizophr. Res."},{"issue":"February (2)","key":"10.1016\/j.neulet.2016.10.003_bib0175","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/acps.12135","article-title":"Trajectories of antipsychotic response in drug-naive schizophrenia patients: results from the 6-month ESPASS follow-up study","volume":"129","author":"Nordon","year":"2014","journal-title":"Acta Psychiatr. Scand."},{"issue":"October (4)","key":"10.1016\/j.neulet.2016.10.003_bib0180","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0447.2012.01883.x","article-title":"Symptomatic and functional remission in patients with first-episode psychosis","volume":"126","author":"Verma","year":"2012","journal-title":"Acta Psychiatr. Scand."},{"issue":"September (7)","key":"10.1016\/j.neulet.2016.10.003_bib0185","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.eurpsy.2014.01.007","article-title":"Impact of primary negative symptoms on functional outcomes in schizophrenia","volume":"29","author":"Fervaha","year":"2014","journal-title":"Eur. Psychiatry"},{"issue":"April (4)","key":"10.1016\/j.neulet.2016.10.003_bib0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1176\/appi.ajp.157.4.549","article-title":"Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates","volume":"157","author":"Bilder","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"July (4)","key":"10.1016\/j.neulet.2016.10.003_bib0195","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/schbul\/sbt085","article-title":"Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis?","volume":"40","author":"Bora","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"September (1\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.schres.2014.07.021","article-title":"Persistent negative symptoms after first episode schizophrenia: a 2-year follow-up study","volume":"158","author":"\u00dc\u00e7ok","year":"2014","journal-title":"Schizophr. Res."},{"issue":"December (1)","key":"10.1016\/j.neulet.2016.10.003_bib0205","article-title":"Thinking and acting beyond the positive: the role of the cognitive and negative symptoms in schizophrenia","volume":"19","author":"Carbon","year":"2014","journal-title":"CNS Spectr."},{"issue":"3","key":"10.1016\/j.neulet.2016.10.003_bib0210","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1751-7893.2007.00036.x","article-title":"Defining, operationalizing and measuring the duration of untreated psychosis: advances, limitations and future directions","volume":"1","author":"Compton","year":"2007","journal-title":"Early Interv. Psychiatry"},{"issue":"January (3)","key":"10.1016\/j.neulet.2016.10.003_bib0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/schbul\/16.3.501","article-title":"Royal park multidiagnostic instrument for psychosis: part I. Rationale and review","volume":"16","author":"McGorry","year":"1990","journal-title":"Schizophr. Bull."},{"issue":"January (3)","key":"10.1016\/j.neulet.2016.10.003_bib0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/schbul\/16.3.517","article-title":"Royal park multidiagnostic instrument for psychosis: part II. Development, reliability, and validity","volume":"16","author":"McGorry","year":"1990","journal-title":"Schizophr. Bull."},{"issue":"August (8)","key":"10.1016\/j.neulet.2016.10.003_bib0225","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archpsyc.1992.01820080023004","article-title":"The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology","volume":"49","author":"Andreasen","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"issue":"March (3)","key":"10.1016\/j.neulet.2016.10.003_bib0230","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0920-9964(92)90004-O","article-title":"IRAOS: an instrument for the assessment of onset and early course of schizophrenia","volume":"6","author":"H\u00e4fner","year":"1992","journal-title":"Schizophr. Res."},{"issue":"July (1)","key":"10.1016\/j.neulet.2016.10.003_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(99)00161-9","article-title":"Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory","volume":"44","author":"Perkins","year":"2000","journal-title":"Schizophr. Res."},{"issue":"December (1\u20133","key":"10.1016\/j.neulet.2016.10.003_bib0240","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.schres.2014.10.025","article-title":"Reliability and validity of methods for measuring the duration of untreated psychosis: a quantitative review and meta-analysis","volume":"160","author":"Register-Brown","year":"2014","journal-title":"Schizophr Res."},{"issue":"December (1)","key":"10.1016\/j.neulet.2016.10.003_bib0245","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.schres.2005.04.018","article-title":"Determining the chronology and components of psychosis onset: the Nottingham Onset Schedule (NOS)","volume":"80","author":"Singh","year":"2005","journal-title":"Schizophr. Res."},{"issue":"January (4)","key":"10.1016\/j.neulet.2016.10.003_bib0250","article-title":"The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness","volume":"70","author":"Velligan","year":"2009","journal-title":"J. Clin. Psychiatry"},{"issue":"October (7)","key":"10.1016\/j.neulet.2016.10.003_bib0255","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0006-3223(99)00084-0","article-title":"Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course?","volume":"46","author":"McGlashan","year":"1999","journal-title":"Biol. Psychiatry"},{"issue":"June (5)","key":"10.1016\/j.neulet.2016.10.003_bib0260","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.eurpsy.2011.11.001","article-title":"Predictors of short- and long-term clinical outcome in schizophrenic psychosis\u2013the Northern Finland 1966 birth cohort study","volume":"28","author":"Juola","year":"2013","journal-title":"Eur. Psychiatry"},{"issue":"December (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0265","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.schres.2005.05.006","article-title":"Social support and three-year symptom and admission outcomes for first episode psychosis","volume":"80","author":"Norman","year":"2005","journal-title":"Schizophr. Res."},{"issue":"January (3\u20134)","key":"10.1016\/j.neulet.2016.10.003_bib0270","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0022-3956(97)00038-1","article-title":"Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible?","volume":"32","author":"Keshavan","year":"1998","journal-title":"J. Psychiatr. Res."},{"issue":"March (1\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0275","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.schres.2006.12.015","article-title":"Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophrenia","volume":"91","author":"Crespo-Facorro","year":"2007","journal-title":"Schizophr. Res."},{"issue":"August (9)","key":"10.1016\/j.neulet.2016.10.003_bib0280","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/npp.2011.65","article-title":"Higher levels of glutamate in the associative-striatum of subjects with prodromal symptoms of schizophrenia and patients with first-episode psychosis","volume":"36","author":"de la Fuente-Sandoval","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"September (5)","key":"10.1016\/j.neulet.2016.10.003_bib0285","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/schbul\/sbt124","article-title":"Reduced frontal glutamate+glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia","volume":"40","author":"Natsubori","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"September (5)","key":"10.1016\/j.neulet.2016.10.003_bib0290","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/YIC.0b013e3280de2c7f","article-title":"Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment","volume":"22","author":"Altamura","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"March (1)","key":"10.1016\/j.neulet.2016.10.003_bib0295","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.schres.2015.01.021","article-title":"Minimal evidence that untreated psychosis damages brain structures: a systematic review","volume":"162","author":"Anderson","year":"2015","journal-title":"Schizophr. Res."},{"issue":"March","key":"10.1016\/j.neulet.2016.10.003_bib0300","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pnpbp.2013.11.009","article-title":"Distinct effects of duration of untreated psychosis on brain cortical activities in different treatment phases of schizophrenia: a multi-channel near-infrared spectroscopy study","volume":"49","author":"Chou","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"July","key":"10.1016\/j.neulet.2016.10.003_bib0305","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pnpbp.2013.02.009","article-title":"Prediction of acute clinical response following a first episode of non affective psychosis: results of a cohort of 375 patients from the Spanish PAFIP study","volume":"44","author":"Crespo-Facorro","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"October (10)","key":"10.1016\/j.neulet.2016.10.003_bib0310","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1176\/appi.ajp.162.10.1785","article-title":"Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis","volume":"162","author":"Perkins","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"October (10)","key":"10.1016\/j.neulet.2016.10.003_bib0315","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3109\/00048674.2010.493503","article-title":"Factors associated with medication non-adherence in patients suffering from schizophrenia: a cross-sectional study in a universal coverage health-care system","volume":"44","author":"Dassa","year":"2010","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"October (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0320","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.schres.2015.06.028","article-title":"Personality domains, duration of untreated psychosis, functioning, and symptom severity in first-episode psychosis","volume":"168","author":"Compton","year":"2015","journal-title":"Schizophr. Res."},{"issue":"July (1)","key":"10.1016\/j.neulet.2016.10.003_bib0325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1192\/bjp.bp.113.126722","article-title":"Insight, duration of untreated psychosis and attachment in first-episode psychosis: prospective study of psychiatric recovery over 12-month follow-up","volume":"205","author":"Gumley","year":"2014","journal-title":"Br. J. Psychiatry"},{"issue":"November","key":"10.1016\/j.neulet.2016.10.003_bib0330","article-title":"Early predictors of ten-year course in first-episode psychosis","author":"Friis","year":"2015","journal-title":"Psychiatr. Serv."},{"issue":"April (4)","key":"10.1016\/j.neulet.2016.10.003_bib0335","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1192\/bjp.bp.109.067694","article-title":"Duration of untreated illness and outcome in schizophrenia: test of predictions in relation to relapse risk","volume":"196","author":"Owens","year":"2010","journal-title":"Br. J. Psychiatry"},{"issue":"October (8)","key":"10.1016\/j.neulet.2016.10.003_bib0340","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.eurpsy.2015.08.004","article-title":"Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset","volume":"30","author":"Ito","year":"2015","journal-title":"Eur. Psychiatry"},{"issue":"September","key":"10.1016\/j.neulet.2016.10.003_bib0345","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1192\/bjp.bp.105.014068","article-title":"Untreated illness and outcome of psychosis","volume":"189","author":"Clarke","year":"2006","journal-title":"Br. J. Psychiatry"},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0350","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1192\/bjp.bp.107.048942","article-title":"Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis","volume":"194","author":"Crumlish","year":"2009","journal-title":"Br. J. Psychiatry"},{"issue":"April (3)","key":"10.1016\/j.neulet.2016.10.003_bib0355","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0920-9964(00)00072-4","article-title":"Is the association between duration of untreated psychosis and outcome confounded? A two year follow-up study of first-admitted patients","volume":"49","author":"Verdoux","year":"2001","journal-title":"Schizophr. Res."},{"issue":"June (2)","key":"10.1016\/j.neulet.2016.10.003_bib0360","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1192\/bjp.bp.114.150623","article-title":"Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase","volume":"207","author":"Valmaggia","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neulet.2016.10.003_bib0365","doi-asserted-by":"crossref","first-page":"s19","DOI":"10.1192\/bjp.187.48.s19","article-title":"Duration of untreated psychosis and its relationship to clinical outcome","volume":"48","author":"Norman","year":"2005","journal-title":"Br. J. Psychiatry"},{"issue":"August (2)","key":"10.1016\/j.neulet.2016.10.003_bib0370","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1192\/bjp.bp.113.127753","article-title":"Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis","volume":"205","author":"Penttil\u00e4","year":"2014","journal-title":"Br. J. Psychiatry"},{"issue":"June (6)","key":"10.1016\/j.neulet.2016.10.003_bib0375","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00127-007-0174-3","article-title":"Delay in treatment for psychosis: its relation to family history","volume":"42","author":"Norman","year":"2007","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"May (5)","key":"10.1016\/j.neulet.2016.10.003_bib0380","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00127-005-0908-z","article-title":"The impact of family experience on the duration of untreated psychosis (DUP) in Hong Kong","volume":"40","author":"Chen","year":"2005","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"May (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0385","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2012.03.001","article-title":"Family history of psychosis negatively impacts age at onset, negative symptoms, and duration of untreated illness and psychosis in first-episode psychosis patients","volume":"197","author":"Esterberg","year":"2012","journal-title":"Psychiatry Res."},{"issue":"July (7)","key":"10.1016\/j.neulet.2016.10.003_bib0390","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00127-013-0786-8","article-title":"Race, ethnicity, and the duration of untreated psychosis: a systematic review","volume":"49","author":"Anderson","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"July (3)","key":"10.1016\/j.neulet.2016.10.003_bib0395","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1037\/0894-4105.12.3.426","article-title":"Neurocognitive deficit in schizophrenia: a quantitative review of the evidence","volume":"12","author":"Heinrichs","year":"1998","journal-title":"Neuropsychology"},{"issue":"September (5)","key":"10.1016\/j.neulet.2016.10.003_bib0400","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/schbul\/sbn044","article-title":"Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders","volume":"35","author":"Reichenberg","year":"2009","journal-title":"Schizophr. Bull."},{"issue":"February (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0405","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.schres.2010.11.017","article-title":"Is cognitive enhancement therapy equally effective for patients with schizophrenia and schizoaffective disorder?","volume":"125","author":"Lewandowski","year":"2011","journal-title":"Schizophr. Res."},{"issue":"March (3)","key":"10.1016\/j.neulet.2016.10.003_bib0410","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1755-5949.2011.00262.x","article-title":"Neurocognitive impairment across the bipolar spectrum","volume":"18","author":"Sole","year":"2012","journal-title":"CNS Neurosci. Ther."},{"issue":"July (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0920-9964(02)00340-7","article-title":"Cognitive functioning in first episode psychosis: initial presentation","volume":"62","author":"Addington","year":"2003","journal-title":"Schizophr. Res."},{"issue":"May (1)","key":"10.1016\/j.neulet.2016.10.003_bib0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(03)00097-5","article-title":"Correlates of cognitive deficits in first episode schizophrenia","volume":"68","author":"Heydebrand","year":"2004","journal-title":"Schizophr. Res."},{"issue":"November (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0425","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.schres.2012.08.019","article-title":"Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis","volume":"141","author":"Cuesta","year":"2012","journal-title":"Schizophr. Res."},{"issue":"September (9)","key":"10.1016\/j.neulet.2016.10.003_bib0430","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1017\/S0033291712002838","article-title":"Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: a 3-year prospective follow-up study","volume":"43","author":"Chang","year":"2013","journal-title":"Psychol. Med."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0435","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.schres.2013.11.018","article-title":"Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: a 2-year longitudinal study","volume":"152","author":"Fraguas","year":"2014","journal-title":"Schizophr. Res."},{"issue":"June (8)","key":"10.1016\/j.neulet.2016.10.003_bib0440","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1017\/S0033291713002341","article-title":"Does active psychosis cause neurobiological pathology? A critical review of the neurotoxicity hypothesis","volume":"44","author":"Rund","year":"2014","journal-title":"Psychol. Med."},{"issue":"December (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0445","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-1781(02)00236-6","article-title":"Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disorders","volume":"113","author":"Townsend","year":"2002","journal-title":"Psychiatry Res."},{"issue":"February (2)","key":"10.1016\/j.neulet.2016.10.003_bib0450","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1017\/S0033291703001156","article-title":"Duration of untreated psychosis: impact on 2-year outcome","volume":"34","author":"Addington","year":"2004","journal-title":"Psychol. Med."},{"issue":"March (1\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0455","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.schres.2006.11.030","article-title":"The course of neurocognitive functioning in first-episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapse","volume":"91","author":"Rund","year":"2007","journal-title":"Schizophr. Res."},{"issue":"September (3)","key":"10.1016\/j.neulet.2016.10.003_bib0460","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1192\/bjp.bp.108.049718","article-title":"Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia","volume":"193","author":"Barnes","year":"2008","journal-title":"Br. J. Psychiatry"},{"issue":"February (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0465","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.schres.2008.11.003","article-title":"Lack of an inverse relationship between duration of untreated psychosis and cognitive function in first episode schizophrenia","volume":"107","author":"Goldberg","year":"2009","journal-title":"Schizophr. Res."},{"issue":"December (2\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0470","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.schres.2009.09.022","article-title":"Correlates of cognitive impairment in first episode schizophrenia: the EUFEST study","volume":"115","author":"Galderisi","year":"2009","journal-title":"Schizophr. Res."},{"issue":"May (4)","key":"10.1016\/j.neulet.2016.10.003_bib0475","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3109\/08039488.2014.929738","article-title":"Effect of time and duration of untreated psychosis on cognitive and social functioning in Chinese patients with first-episode schizophrenia: a 1-year study","volume":"69","author":"Heeramun-Aubeeluck","year":"2015","journal-title":"Nord. J. Psychiatry"},{"issue":"April (1\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0480","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.schres.2012.12.016","article-title":"Duration of untreated psychosis and cognitive functioning","volume":"145","author":"Rapp","year":"2013","journal-title":"Schizophr. Res."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0485","first-page":"87","article-title":"Neurocognition and duration of psychosis: a 10-year follow-up of first-episode patients","volume":"42","author":"Rund","year":"2016","journal-title":"Schizophr. Bull."},{"issue":"November (6)","key":"10.1016\/j.neulet.2016.10.003_bib0490","first-page":"1363","article-title":"The myth of schizophrenia as a progressive brain disease","volume":"39","author":"Zipursky","year":"2012","journal-title":"Schizophr. Bull."},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0495","doi-asserted-by":"crossref","first-page":"f185","DOI":"10.1136\/bmj.f185","article-title":"Early interventions to prevent psychosis: systematic review and meta-analysis","volume":"346","author":"Stafford","year":"2013","journal-title":"BMJ"},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0500","doi-asserted-by":"crossref","first-page":"f304","DOI":"10.1136\/bmj.f304","article-title":"Can we identify and treat \u2018schizophrenia light\u2019 to prevent true psychotic illness?","volume":"346","author":"van Os","year":"2013","journal-title":"BMJ"},{"issue":"October (1)","key":"10.1016\/j.neulet.2016.10.003_bib0505","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.schres.2010.05.004","article-title":"An evidence map of interventions across premorbid, ultra-high risk and first episode phases of psychosis","volume":"123","author":"Liu","year":"2010","journal-title":"Schizophr. Res."},{"issue":"October (3)","key":"10.1016\/j.neulet.2016.10.003_bib0510","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/j.2051-5545.2008.tb00182.x","article-title":"Early intervention in psychosis: concepts, evidence and future directions","volume":"7","author":"McGorry","year":"2008","journal-title":"World Psychiatry"},{"issue":"October (1\u20132)","key":"10.1016\/j.neulet.2016.10.003_bib0515","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.schres.2015.08.020","article-title":"Essential components of early intervention programs for psychosis: available intervention services in the United States","volume":"168","author":"White","year":"2015","journal-title":"Schizophr. Res."},{"issue":"August (8)","key":"10.1016\/j.neulet.2016.10.003_bib0520","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/j.1440-1614.2006.01860.x","article-title":"Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions","volume":"40","author":"McGorry","year":"2006","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"November (8934)","key":"10.1016\/j.neulet.2016.10.003_bib0525","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0140-6736(94)90569-X","article-title":"Child development risk factors for adult schizophrenia in the British 1946 birth cohort","volume":"344","author":"Jones","year":"1994","journal-title":"Lancet (London, England)"},{"issue":"March (1)","key":"10.1016\/j.neulet.2016.10.003_bib0530","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0920-9964(02)00167-6","article-title":"Psychosis prediction: 12-month follow up of a high-risk (\u2018prodromal\u2019) group","volume":"60","author":"Yung","year":"2003","journal-title":"Schizophr. Res."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0535","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1001\/archgenpsychiatry.2007.3","article-title":"Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America","volume":"65","author":"Cannon","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"issue":"August (1)","key":"10.1016\/j.neulet.2016.10.003_bib0540","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0920-9964(01)00237-7","article-title":"Early detection strategies for untreated first-episode psychosis","volume":"51","author":"Johannessen","year":"2001","journal-title":"Schizophr. Res."},{"issue":"January (2)","key":"10.1016\/j.neulet.2016.10.003_bib0545","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/schbul\/22.2.283","article-title":"Monitoring and care of young people at incipient risk of psychosis","volume":"22","author":"Yung","year":"1996","journal-title":"Schizophr. Bull."},{"issue":"October (1)","key":"10.1016\/j.neulet.2016.10.003_bib0550","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.schres.2010.07.026","article-title":"Randomized-controlled trials in people at ultra high risk of psychosis: a review of treatment effectiveness","volume":"123","author":"Preti","year":"2010","journal-title":"Schizophr. Res."},{"issue":"January (1)","key":"10.1016\/j.neulet.2016.10.003_bib0555","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/jamapsychiatry.2013.269","article-title":"The psychosis high-risk state: a comprehensive state-of-the-art review","volume":"70","author":"Fusar-Poli","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"November (11)","key":"10.1016\/j.neulet.2016.10.003_bib0560","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1176\/appi.ajp.158.11.1917","article-title":"Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment","volume":"158","author":"Larsen","year":"2001","journal-title":"Am. J. Psychiatry"},{"issue":"February (2)","key":"10.1016\/j.neulet.2016.10.003_bib0565","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archpsyc.61.2.143","article-title":"Reducing the duration of untreated first-episode psychosis: effects on clinical presentation","volume":"61","author":"Melle","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"issue":"April (4)","key":"10.1016\/j.neulet.2016.10.003_bib0570","first-page":"374","article-title":"Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome","volume":"169","author":"ten","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"December (2)","key":"10.1016\/j.neulet.2016.10.003_bib0575","first-page":"1","article-title":"Heterogeneity of psychosis risk within individuals at clinical high risk: a meta-analytical stratification","volume":"73","author":"Fusar-Poli","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0580","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-244X-14-72","article-title":"Which pathways to psychiatric care lead to earlier treatment and a shorter duration of first-episode psychosis?","volume":"14","author":"Bhui","year":"2014","journal-title":"BMC Psychiatry"},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0585","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12888-015-0650-3","article-title":"The Early Psychosis Intervention Center (EPICENTER): development and six-month outcomes of an American first-episode psychosis clinical service","volume":"15","author":"Breitborde","year":"2015","journal-title":"BMC Psychiatry"},{"issue":"June","key":"10.1016\/j.neulet.2016.10.003_bib0590","article-title":"Four-year cost-effectiveness of cognitive behavior therapy for preventing first-episode psychosis: the Dutch early detection intervention evaluation (EDIE-NL) trial","author":"Ising","year":"2016","journal-title":"Schizophr. Bull."},{"issue":"May (7)","key":"10.1016\/j.neulet.2016.10.003_bib0595","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1017\/S0033291714002530","article-title":"Cost-effectiveness of preventing first-episode psychosis in ultra-high-risk subjects: multi-centre randomized controlled trial","volume":"45","author":"Ising","year":"2015","journal-title":"Psychol. Med."},{"issue":"September (1\u20133)","key":"10.1016\/j.neulet.2016.10.003_bib0600","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.schres.2013.07.004","article-title":"Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups","volume":"149","author":"van der Gaag","year":"2013","journal-title":"Schizophr. Res."},{"issue":"January","key":"10.1016\/j.neulet.2016.10.003_bib0605","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1471-244X-11-157","article-title":"Service user and carer experiences of seeking help for a first episode of psychosis: a UK qualitative study","volume":"11","author":"Tanskanen","year":"2011","journal-title":"BMC Psychiatry"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016307455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016307455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T23:45:06Z","timestamp":1657410306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016307455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":121,"alternative-id":["S0304394016307455"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.10.003","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Duration of untreated illness as a key to early intervention in schizophrenia: A review","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}