{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:36:10Z","timestamp":1782902170645,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF-2014R1A2A2A01007909"],"award-info":[{"award-number":["NRF-2014R1A2A2A01007909"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.neulet.2016.12.018","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T20:40:53Z","timestamp":1481316053000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats"],"prefix":"10.1016","volume":"638","author":[{"given":"Jae-Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Joung","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2016.12.018_bib0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer\u2019s disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2016.12.018_bib0010","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/ncpneuro0294","article-title":"Vascular cognitive impairment","volume":"2","author":"Selnes","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.neulet.2016.12.018_bib0015","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neulet.2016.12.018_bib0020","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.jcbfm.9600259","article-title":"The chronic vascular and haemodynamic response after permanent bilateral common carotid occlusion in newborn and adult rats","volume":"26","author":"Choy","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2016.12.018_bib0025","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/jcbfm.2015.55","article-title":"Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment","volume":"35","author":"Jing","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2016.12.018_bib0030","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1124\/jpet.106.118760","article-title":"l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats","volume":"321","author":"Peng","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2016.12.018_bib0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4196\/kjpp.2008.12.3.89","article-title":"White matter damage and hippocampal neurodegeneration induced by permanent bilateral occlusion of common carotid artery in the rat: comparison between wistar and Sprague-Dawley strain","volume":"12","author":"Kim","year":"2008","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.neulet.2016.12.018_bib0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/s12906-015-0943-6","article-title":"Salvia miltiorrhiza extract protects white matter and the hippocampus from damage induced by chronic cerebral hypoperfusion in rats","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.neulet.2016.12.018_bib0045","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10072-011-0872-1","article-title":"Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion","volume":"33","author":"Ganzella","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbr.2013.04.010","article-title":"Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice","volume":"249","author":"Soares","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2016.12.018_bib0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00004647-200201000-00012","article-title":"Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion","volume":"22","author":"Ueno","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2016.12.018_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: an overview: structure, regulation, and clinical implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2016.12.018_bib0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neulet.2016.12.018_bib0070","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/01.STR.32.5.1162","article-title":"White matter damage is associated with matrix metalloproteinases in vascular dementia","volume":"32","author":"Rosenberg","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2016.12.018_bib0075","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1161\/STROKEAHA.110.608257","article-title":"Blood-brain barrier breakdown in acute and chronic cerebrovascular disease","volume":"42","author":"Yang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2016.12.018_bib0080","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","article-title":"Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs","volume":"15","author":"Verma","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.neulet.2016.12.018_bib0085","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1161\/01.STR.0000244808.17972.55","article-title":"Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents","volume":"37","author":"Nakaji","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2016.12.018_bib0090","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia","volume":"27","author":"Svedin","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0095","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: a behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5213\/inj.2014.18.1.16","article-title":"Treadmill exercise ameliorates short-term memory disturbance in scopolamine-induced amnesia rats","volume":"18","author":"Heo","year":"2014","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.neulet.2016.12.018_bib0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5213\/inj.2014.18.4.187","article-title":"Aerobic exercise alleviates ischemia-induced memory impairment by enhancing cell proliferation and suppressing neuronal apoptosis in hippocampus","volume":"18","author":"Seo","year":"2015","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.neulet.2016.12.018_bib0110","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.lfs.2012.10.003","article-title":"Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice","volume":"91","author":"Sung","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0115","first-page":"529","article-title":"Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE\/APPsw-transgenic model","volume":"22","author":"Um","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neulet.2016.12.018_bib0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1179\/016164107X204701","article-title":"Exercise pre-conditioning ameliorates blood-brain barrier dysfunction in stroke by enhancing basal lamina","volume":"29","author":"Davis","year":"2007","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neulet.2016.12.018_bib0125","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuroscience.2007.10.006","article-title":"Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke","volume":"151","author":"Guo","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2016.12.018_bib0130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-2003-38202","article-title":"Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats","volume":"24","author":"Kim","year":"2003","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.neulet.2016.12.018_bib0135","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.exger.2010.02.005","article-title":"Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus","volume":"45","author":"Kim","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neulet.2016.12.018_bib0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jbmt.2007.05.004","article-title":"Effects of treadmill running on mid-term memory and swim speed in the rat with Morris water maze test","volume":"12","author":"Alaei","year":"2008","journal-title":"J. Bodyw. Mov. Ther."},{"key":"10.1016\/j.neulet.2016.12.018_bib0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12965\/jer.140102","article-title":"Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer\u2019s disease rats","volume":"10","author":"Sim","year":"2014","journal-title":"J. Exercise Rehabil."},{"key":"10.1016\/j.neulet.2016.12.018_bib0150","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.nlm.2011.09.008","article-title":"Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat","volume":"97","author":"Cechetti","year":"2011","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.neulet.2016.12.018_bib0155","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1038\/tp.2016.65","article-title":"Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model","volume":"6","author":"Huttenrauch","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neulet.2016.12.018_bib0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/brain\/awq347","article-title":"White matter damage and cognitive impairment after traumatic brain injury","volume":"134","author":"Kinnunen","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2016.12.018_bib0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12906-015-0652-1","article-title":"Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling","volume":"15","author":"Lee","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.neulet.2016.12.018_bib0170","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/01.STR.29.5.1058","article-title":"White matter changes in the gerbil brain under chronic cerebral hypoperfusion","volume":"29","author":"Kurumatani","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2016.12.018_bib0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0006-8993(01)03223-1","article-title":"Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat","volume":"924","author":"Wakita","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2016.12.018_bib0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0306-4522(98)00659-9","article-title":"Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment","volume":"91","author":"De Jong","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2016.12.018_bib0185","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuroscience.2003.12.029","article-title":"Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin","volume":"124","author":"Ding","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2016.12.018_bib0190","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/hipo.20545","article-title":"Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis","volume":"19","author":"Van der Borght","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.neulet.2016.12.018_bib0195","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1523\/JNEUROSCI.21-19-07724.2001","article-title":"Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia","volume":"21","author":"Asahi","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0200","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2016.12.018_bib0205","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2016.12.018_bib0210","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0215","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/apha.12250","article-title":"The neurovascular unit\u2014concept review","volume":"210","author":"Muoio","year":"2014","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.neulet.2016.12.018_bib0220","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jep.2011.08.063","article-title":"Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells","volume":"141","author":"Zhu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neulet.2016.12.018_bib0225","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.bbrc.2005.11.133","article-title":"Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries","volume":"339","author":"Kago","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2016.12.018_bib0230","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12031-011-9496-4","article-title":"Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult","volume":"44","author":"Jiao","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0235","doi-asserted-by":"crossref","first-page":"11096","DOI":"10.3390\/ijms140611096","article-title":"Early exercise protects the blood-brain barrier from ischemic brain injury via the regulation of MMP-9 and occludin in rats","volume":"14","author":"Zhang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2016.12.018_bib0240","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/jcbfm.2010.195","article-title":"Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition","volume":"31","author":"Wang","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."}],"updated-by":[{"DOI":"10.1016\/j.neulet.2017.02.067","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000}}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016309533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394016309533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:19:33Z","timestamp":1759609173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394016309533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":48,"alternative-id":["S0304394016309533"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2016.12.018","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2016.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}