{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:57:52Z","timestamp":1789883872614,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371065"],"award-info":[{"award-number":["31371065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Health Bureau and Family Planning","award":["20154Y0062"],"award-info":[{"award-number":["20154Y0062"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.neulet.2017.03.001","type":"journal-article","created":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T02:18:33Z","timestamp":1488680313000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice"],"prefix":"10.1016","volume":"645","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.03.001_bib0005","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1056\/NEJMcp1107281","article-title":"Clinical practice. Secondary prevention after ischemic stroke or transient ischemic attack","volume":"366","author":"Davis","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0010","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3\u20134.5hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0015","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","article-title":"Endovascular therapy for ischemic stroke with perfusion-imaging selection","volume":"372","author":"Campbell","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0020","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/jcbfm.2010.149","article-title":"The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity","volume":"30","author":"Harston","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0025","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/jcbfm.2011.127","article-title":"Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence","volume":"31","author":"Vivien","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2995","article-title":"Engaging neuroscience to advance translational research in brain barrier biology","volume":"12","author":"Neuwelt","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.03.001_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.03.001_bib0040","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0045","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10715760902751902","article-title":"Involvement of ROS in BBB dysfunction","volume":"43","author":"Pun","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neulet.2017.03.001_bib0050","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/jcbfm.2011.9","article-title":"Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment","volume":"31","author":"Kanazawa","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0055","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0002-9440(10)64285-X","article-title":"Angiopoietin-like 4 is a proangiogenic factor pro- duced during ischemia and in conventional renal cell carcinoma","volume":"162","author":"Le Jan","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0060","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/01.wnr.0000224776.12647.ba","article-title":"Increased expression of the adipokines resistin and fiaf in hypoxic\/ischemic mouse brain","volume":"17","author":"Wiesner","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2017.03.001_bib0065","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/CIRCULATIONAHA.111.049072","article-title":"Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4","volume":"125","author":"Galaup","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.neulet.2017.03.001_bib0070","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.07.046","article-title":"Upregulation of ANGPTL4 messenger RNA and protein in se- verely calcified carotid plaques","author":"Katano","year":"2014","journal-title":"Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.neulet.2017.03.001_bib0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00011-013-0678-0","article-title":"Role of Angptl4 in vascular permeability and inflammation","volume":"63","author":"Guo","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.neulet.2017.03.001_bib0080","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/ATVBAHA.113.301698","article-title":"Overexpression of angiopoietin-like protein 4 protects against ath- erosclerosis development","author":"Georgiadi","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0085","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1093\/eurheartj\/eht183","article-title":"Angiopoietin-like 4 and ischaemic stroke: a promising start","volume":"34","author":"Spescha","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.neulet.2017.03.001_bib0090","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1093\/eurheartj\/eht153","article-title":"Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke","volume":"34","author":"Bouleti","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.neulet.2017.03.001_bib0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2040-7378-3-5","article-title":"Early outcome and blood-brain barrier integrity after co-administered thrombolysis and hyperbaric oxygenation in experimental stroke","volume":"3","author":"Michalski","year":"2011","journal-title":"Exp. Transl. Stroke Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(97)00580-5","article-title":"A rat model of focal embolic cerebral ischemia","volume":"766","author":"Zhang","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.03.001_bib0105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/01.WCB.0000125365.83980.00","article-title":"Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice","volume":"4","author":"Gibson","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.23762","article-title":"Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice","volume":"73","author":"Wang","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0115","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/sj.jcbfm.9600375","article-title":"Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat","volume":"27","author":"Yang","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood\u2013brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neulet.2017.03.001_bib0125","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00004647-199906000-00005","article-title":"Matrix metalloproteinases increase very early during experimental fo- cal cerebral ischemia","volume":"19","author":"Heo","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0130","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1172\/JCI200420702","article-title":"Src blockade stabilizes a Flk\/cadherin complex, reducing edema and tissue injury following myocardial infarction","volume":"113","author":"Weis","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2017.03.001_bib0135","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/CIRCULATIONAHA.111.049072","article-title":"Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4","volume":"125","author":"Galaup","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.neulet.2017.03.001_bib0140","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00004647-200005000-00001","article-title":"Serine protease inhibitors: novel therapeutic targets for stroke?","volume":"20","author":"Vivien","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.03.001_bib0145","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2017.03.001_bib0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jnr.23300","article-title":"Blood-brain barrier and traumatic brain injury","volume":"92","author":"Alves","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2017.03.001_bib0155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1254\/jphs.10R01CP","article-title":"Role of tissue-type plasminogen activator in ischemic stroke","volume":"113","author":"Suzuki","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.neulet.2017.03.001_bib0160","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1523\/JNEUROSCI.6409-11.2012","article-title":"Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood brain barrier damage in early ischemic stroke stage","volume":"32","author":"Liu","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.03.001_bib0165","first-page":"2385","article-title":"Early disruption of the blood-brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke","volume":"39","author":"Kastrup","year":"2008","journal-title":"Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.neulet.2017.03.001_bib0170","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1073\/pnas.96.17.9815","article-title":"Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo","volume":"96","author":"Corada","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.03.001_bib0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejheart.2006.04.013","article-title":"Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel","volume":"9","author":"Yang","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.neulet.2017.03.001_bib0180","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1161\/STROKEAHA.109.554824","article-title":"Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats","volume":"40","author":"Park","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.03.001_bib0185","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1749-6632.2010.05734.x","article-title":"Metallopro- teinase and stroke infarct size: role for anti-inflammatory treat- ment?","volume":"1207","author":"Morancho","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2017.03.001_bib0190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.23762","article-title":"Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice","volume":"73","author":"Wang","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0195","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.STR.0000177517.01203.eb","article-title":"Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia","volume":"36","author":"Tsuji","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.03.001_bib0200","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.expneurol.2006.01.032","article-title":"Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis","volume":"200","author":"Kelly","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0205","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature03987","article-title":"Pathophysiological consequences of VEGF-induced vascular permeability","volume":"437","author":"Weis","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.03.001_bib0210","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ncomms2199","article-title":"Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo","volume":"3","author":"Orsenigo","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2017.03.001_bib0215","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.200408130","article-title":"Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis","volume":"167","author":"Weis","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2017.03.001_bib0220","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/sj.onc.1209855","article-title":"Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site","volume":"15","author":"Wallez","year":"2007","journal-title":"Oncogene"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T05:21:43Z","timestamp":1568870503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017302033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":44,"alternative-id":["S0304394017302033"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.001","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}