{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:36:56Z","timestamp":1770914216822,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National natural science foundation of China","doi-asserted-by":"publisher","award":["81601931"],"award-info":[{"award-number":["81601931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National science foundation of Jiangsu province","award":["BK20150475"],"award-info":[{"award-number":["BK20150475"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.neulet.2017.03.009","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T13:32:22Z","timestamp":1488979942000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["CaSR and calpain contribute to the ischemia reperfusion injury of spinal cord"],"prefix":"10.1016","volume":"646","author":[{"given":"Ji-Fu","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Bing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Ming","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run-Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.03.009_bib0005","first-page":"1","article-title":"Neuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia\/reperfusion injury in rabbits","volume":"29","author":"Boyaci","year":"2014","journal-title":"Br. J. Neurosurg."},{"key":"10.1016\/j.neulet.2017.03.009_bib0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0896-6273(93)90180-Y","article-title":"Cell-permeant Ca 2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo","volume":"11","author":"Tymianski","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2017.03.009_bib0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nn0308-243","article-title":"Calcium: first messenger","volume":"11","author":"Spitzer","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.03.009_bib0020","doi-asserted-by":"crossref","first-page":"F518","DOI":"10.1152\/ajprenal.00208.2015","article-title":"Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney","volume":"310","author":"Graca","year":"2016","journal-title":"Am. J. Physiol. Renal."},{"key":"10.1016\/j.neulet.2017.03.009_bib0025","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bbrc.2006.06.176","article-title":"Involvement of calcium-sensing receptor in ischemia\/reperfusion-induced apoptosis in rat cardiomyocytes","volume":"347","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2017.03.009_bib0030","first-page":"128","article-title":"Activation of the calcium-sensing receptor before renal ischemia\/reperfusion exacerbates kidney injury","volume":"7","author":"Weekers","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.neulet.2017.03.009_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ceca.2003.10.008","article-title":"Calcium-sensing receptor in the brain","volume":"35","author":"Yano","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neulet.2017.03.009_bib0040","first-page":"911","article-title":"Activation of the calcium-sensing receptor promotes apoptosis by modulating the JNK\/p38 MAPK pathway in focal cerebral ischemia-reperfusion in mice","volume":"8","author":"Zhen","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.neulet.2017.03.009_bib0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12576-012-0243-6","article-title":"A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts","volume":"63","author":"Takeshita","year":"2013","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.neulet.2017.03.009_bib0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005072-198203000-00004","article-title":"Neuropathology of experimental spinal cord ischemia in the rabbit","volume":"41","author":"Degirolami","year":"1982","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2017.03.009_bib0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuroscience.2016.04.019","article-title":"Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats","volume":"328","author":"Fang","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.03.009_bib0060","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jns.2016.05.015","article-title":"Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro","volume":"366","author":"Pak","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2017.03.009_bib0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-8993(96)01070-0","article-title":"Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization","volume":"744","author":"Rogers","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.03.009_bib0070","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fphys.2016.00116","article-title":"Calcium-sensing receptor: a key target for extracellular calcium signaling in neurons","volume":"7","author":"Jones","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neulet.2017.03.009_bib0075","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/(SICI)1098-1136(199812)24:4<449::AID-GLIA10>3.0.CO;2-9","article-title":"Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel","volume":"24","author":"Chattopadhyay","year":"1998","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2017.03.009_bib0080","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11010-010-0493-7","article-title":"The functional expression of calcium-sensing receptors in BRL cells and related signal transduction pathway responsible for intracellular calcium elevation","volume":"343","author":"Xing","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.neulet.2017.03.009_bib0085","first-page":"9941","article-title":"Ischemia-reperfusion model in rat spinal cord: cell viability and apoptosis signaling study","volume":"8","author":"de Lavor","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neulet.2017.03.009_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molcel.2014.10.028","article-title":"Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis","volume":"57","author":"Renault","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neulet.2017.03.009_bib0095","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cellbi.2008.03.009","article-title":"Calcium-sensing receptors induce apoptosis in cultured neonatal rat ventricular cardiomyocytes during simulated ischemia\/reperfusion","volume":"32","author":"Jiang","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.neulet.2017.03.009_bib0100","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/10715762.2016.1154549","article-title":"Tetrahydropalmatine protects rat pulmonary endothelial cells from irradiation-induced apoptosis by inhibiting oxidative stress and the calcium sensing receptor\/phospholipase C-\u03b31 pathway","author":"Yu","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neulet.2017.03.009_bib0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11033-014-3763-8","article-title":"Parathyroid hormone-related protein overexpression protects goat mammary gland epithelial cells from calcium-sensing receptor activation-induced apoptosis","volume":"42","author":"Li","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.neulet.2017.03.009_bib0110","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.molimm.2014.08.007","article-title":"Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis","volume":"63","author":"Wu","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.neulet.2017.03.009_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.STR.29.5.1007","article-title":"Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia","volume":"29","author":"Hayashi","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.03.009_bib0120","doi-asserted-by":"crossref","first-page":"e65147","DOI":"10.1371\/journal.pone.0065147","article-title":"Crucial role of calcium-sensing receptor activation in cardiac injury of diabetic rats","volume":"8","author":"Qi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2017.03.009_bib0125","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1089\/neu.2012.2691","article-title":"Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury","volume":"30","author":"Kim","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neulet.2017.03.009_bib0130","doi-asserted-by":"crossref","first-page":"31167","DOI":"10.1074\/jbc.M303377200","article-title":"m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR","volume":"278","author":"Kifor","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.03.009_bib0135","first-page":"52","article-title":"Cyclosporin A induces cardiomyocyte injury through calcium-sensing receptor-mediated calcium overload","volume":"66","author":"Tang","year":"2011","journal-title":"Pharmazie"},{"key":"10.1016\/j.neulet.2017.03.009_bib0140","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1159\/000350091","article-title":"Role of the calcium-sensing receptor in cardiomyocyte apoptosis via the sarcoplasmic reticulum and mitochondrial death pathway in cardiac hypertrophy and heart failure","volume":"31","author":"Lu","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.neulet.2017.03.009_bib0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/jnc.13770","article-title":"Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis","volume":"139","author":"Smith","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.03.009_bib0150","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s12035-014-8898-z","article-title":"Degradation of \u03b2II-spectrin protein by calpain-2 and caspase-3 under neurotoxic and traumatic brain injury conditions","volume":"52","author":"Kobeissy","year":"2014","journal-title":"Mol. Neurobiol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:19:35Z","timestamp":1759609175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017302197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":30,"alternative-id":["S0304394017302197"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.009","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CaSR and calpain contribute to the ischemia reperfusion injury of spinal cord","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}