{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:35:37Z","timestamp":1791876937920,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.neulet.2017.03.030","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T14:45:34Z","timestamp":1490021134000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Knockdown of APPL mimics transgenic A\u03b2 induced neurodegenerative phenotypes in Drosophila"],"prefix":"10.1016","volume":"648","author":[{"given":"Sandeep Kumar","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Srivastav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarish Kumar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saripella","family":"Srikrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"s1","key":"10.1016\/j.neulet.2017.03.030_bib0005","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1471-4159.2011.07519.x","article-title":"Proteolytic processing of Alzheimer's \u03b2-amyloid precursor protein","volume":"120","author":"Zhang","year":"2012","journal-title":"J. Neurochem."},{"issue":"44","key":"10.1016\/j.neulet.2017.03.030_bib0010","doi-asserted-by":"publisher","first-page":"29615","DOI":"10.1074\/jbc.R800019200","article-title":"Amyloid precursor protein trafficking, processing, and function","volume":"283","author":"Thinakaran","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"8762","key":"10.1016\/j.neulet.2017.03.030_bib0015","first-page":"1","article-title":"Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease","volume":"6","author":"Zhang","year":"2015","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.neulet.2017.03.030_bib0020","doi-asserted-by":"publisher","first-page":"12045","DOI":"10.1073\/pnas.90.24.12045","article-title":"apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor","volume":"90","author":"Daigle","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.neulet.2017.03.030_bib0025","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1073\/pnas.86.7.2478","article-title":"A Drosophila gene encoding a protein resembling the human \u03b2-amyloid protein precursor","volume":"86","author":"Rosen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2017.03.030_bib0030","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/0006-291X(92)90254-I","article-title":"A Xenopus homologue of the human beta-amyloid precursor protein: developmental regulation of its gene expression","volume":"189","author":"Okado","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2017.03.030_bib0035","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.03.030_bib0040","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/ng0993-95","article-title":"Isolation and characterization of the human APLP2 gene encoding a homologue of the Alzheimer's associated amyloid \u03b2 protein precursor","volume":"5","author":"Wasco","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.03.030_bib0045","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1021\/bi00068a002","article-title":"Molecular cloning of cDNA for a human amyloid precursor protein homologue: evidence for a multigene family","volume":"32","author":"Sprecher","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.neulet.2017.03.030_bib0050","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/331530a0","article-title":"Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity","volume":"331","author":"Kitagchi","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.03.030_bib0055","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/331525a0","article-title":"A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors","volume":"331","author":"Ponte","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.03.030_bib0060","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/331528a0","article-title":"Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease","volume":"331","author":"Tanzi","year":"1988","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.neulet.2017.03.030_bib0065","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.tips.2016.01.005","article-title":"APP receptor? To be or not to be","volume":"37","author":"Deyts","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"2016","key":"10.1016\/j.neulet.2017.03.030_bib0070","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jocs.2016.03.007","article-title":"Identification of common therapeutic targets for selected neurodegenerative disorders: an in silico approach","volume":"17","author":"Ahmad","year":"2016","journal-title":"J. Comput. Sci."},{"key":"10.1016\/j.neulet.2017.03.030_bib0075","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.2174\/1871527313666141023120843","article-title":"Identification of potent caspase-3 inhibitors for treatment of multi-neurodegenerative diseases using pharmacophore modeling and docking approaches","volume":"13","author":"Ahmad","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"4","key":"10.1016\/j.neulet.2017.03.030_bib0080","doi-asserted-by":"publisher","first-page":"191","DOI":"10.6026\/97320630010191","article-title":"Structure based molecular inhibition of caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds","volume":"10","author":"Ahmad","year":"2014","journal-title":"Bioinformation"},{"issue":"5","key":"10.1016\/j.neulet.2017.03.030_bib0085","doi-asserted-by":"publisher","first-page":"e1001562","DOI":"10.1371\/journal.pbio.1001562","article-title":"The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling","volume":"11","author":"Soldano","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neulet.2017.03.030_bib0090","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0896-6273(92)90024-8","article-title":"Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene","volume":"9","author":"Luo","year":"1992","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.neulet.2017.03.030_bib0095","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1523\/JNEUROSCI.2896-10.2011","article-title":"Drosophila amyloid precursor protein-like is required for long-term memory","volume":"31","author":"Goguel","year":"2011","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.neulet.2017.03.030_bib0100","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12640-014-9466-z","article-title":"The flavonoid derivative 2-(4\u2032 benzyloxyphenyl)-3-hydroxy-chromen-4-one protects against A\u03b242-induced neurodegeneration in transgenic Drosophila: insights from in silico and in vivo studies","volume":"26","author":"Singh","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neulet.2017.03.030_bib0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.neulet.2017.03.030_bib0110","article-title":"Preparation of Drosophila eye specimens for scanning electron microscopy","author":"Wolff","year":"2011","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.neulet.2017.03.030_bib0115","first-page":"2013","article-title":"Neuroprotective role of a novel copper chelator against induced neurotoxicity","author":"Singh","year":"2013","journal-title":"Int. J. Alzheimer's Dis."},{"key":"10.1016\/j.neulet.2017.03.030_bib0120","first-page":"2016","article-title":"Overview of Alzheimer's disease and some therapeutic approaches targeting A\u03b2 by using several synthetic and herbal compounds","author":"Singh","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neulet.2017.03.030_bib0125","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00429-009-0234-4","article-title":"Transgenic Drosophila models of Alzheimer's disease and tauopathies","volume":"214","author":"Iijima-Ando","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neulet.2017.03.030_bib0130","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1007\/s00018-009-0020-8","article-title":"Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors","volume":"66","author":"Jacobsen","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"issue":"61","key":"10.1016\/j.neulet.2017.03.030_bib0135","first-page":"1","article-title":"Analysis of amyloid precursor protein function in Drosophila melanogaster","volume":"9","author":"Cassar","year":"2016","journal-title":"Front. Mol. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017302501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T14:23:48Z","timestamp":1658845428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017302501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":27,"alternative-id":["S0304394017302501"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.030","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of APPL mimics transgenic A\u03b2 induced neurodegenerative phenotypes in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}