{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:12:16Z","timestamp":1790244736356,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National 863 program of China","award":["2015AA020514"],"award-info":[{"award-number":["2015AA020514"]}]},{"name":"NSFC grants","award":["61501452"],"award-info":[{"award-number":["61501452"]}]},{"name":"SSTP program","award":["ZXY201426"],"award-info":[{"award-number":["ZXY201426"]}]},{"name":"Jiangsu Key Research and Development programs","award":["BE2016613"],"award-info":[{"award-number":["BE2016613"]}]},{"name":"Jiangsu Key Research and Development programs","award":["BE2016010"],"award-info":[{"award-number":["BE2016010"]}]},{"name":"Jiangsu Key Research and Development programs","award":["BE2016010-3"],"award-info":[{"award-number":["BE2016010-3"]}]},{"name":"Jiangsu Key Research and Development programs","award":["BE2016010-4"],"award-info":[{"award-number":["BE2016010-4"]}]},{"DOI":"10.13039\/501100002949","name":"Jiangsu province","doi-asserted-by":"crossref","award":["1501089C"],"award-info":[{"award-number":["1501089C"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BKLN program"},{"name":"Suzhou scientific and technologic programs","award":["ZXY201426"],"award-info":[{"award-number":["ZXY201426"]}]},{"name":"Suzhou scientific and technologic programs","award":["SYG201606"],"award-info":[{"award-number":["SYG201606"]}]},{"name":"Suzhou scientific and technologic programs","award":["SZS201609"],"award-info":[{"award-number":["SZS201609"]}]},{"name":"SND medical plan project","award":["2016Z010"],"award-info":[{"award-number":["2016Z010"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neulet.2017.04.034","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T01:47:25Z","timestamp":1492739245000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["A multilevel-ROI-features-based machine learning method for detection of morphometric biomarkers in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"651","author":[{"given":"Bo","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baotong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.neulet.2017.04.034_bib0005","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"issue":"S3","key":"10.1016\/j.neulet.2017.04.034_bib0010","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.23829","article-title":"The movement disorder society evidence-based medicine review update: treatments for the motor symptoms of Parkinson\u2019s disease","volume":"26","author":"Fox","year":"2011","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.neulet.2017.04.034_bib0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","article-title":"Non-motor symptoms of Parkinson\u2019s disease: dopaminergic pathophysiology and treatment","volume":"8","author":"Chaudhuri","year":"2009","journal-title":"The Lancet Neurology"},{"issue":"3","key":"10.1016\/j.neulet.2017.04.034_bib0020","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ageing\/afm040","article-title":"NICE guideline for Parkinson\u2019s disease","volume":"36","author":"Stewart","year":"2007","journal-title":"Age Ageing"},{"issue":"13","key":"10.1016\/j.neulet.2017.04.034_bib0025","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/mds.22245","article-title":"MR-spectroscopic findings in juvenile-onset Huntington\u2019s disease","volume":"23","author":"Reynolds","year":"2008","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.neulet.2017.04.034_bib0030","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/brain\/awm319","article-title":"Automatic classification of MR scans in Alzheimer\u2019s disease","volume":"131","author":"Kl\u00f6ppel","year":"2008","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neulet.2017.04.034_bib0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroimage.2007.07.008","article-title":"Multivariate deformation-based analysis of brain atrophy to predict Alzheimer\u2019s disease in mild cognitive impairment","volume":"38","author":"Teipel","year":"2007","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neulet.2017.04.034_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000070676","article-title":"MRI study of caudate nucleus volume in Parkinson\u2019s disease with and without dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"16","author":"Almeida","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"11","key":"10.1016\/j.neulet.2017.04.034_bib0045","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00415-005-0864-2","article-title":"Longitudinal evaluation of cerebral morphological changes in Parkinson\u2019s disease with and without dementia","volume":"252","author":"Ram\u00edrez-Ruiz","year":"2005","journal-title":"J. Neurol."},{"issue":"12","key":"10.1016\/j.neulet.2017.04.034_bib0050","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.clineuro.2013.10.002","article-title":"Mindfulness based intervention in Parkinson\u2019s disease leads to structural brain changes on MRI: a randomized controlled longitudinal trial","volume":"115","author":"Pickut","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"10.1016\/j.neulet.2017.04.034_bib0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The parkinson progression marker initiative (PPMI)","volume":"95","author":"Marek","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2017.04.034_bib0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2015.08.030","article-title":"Cerebral alterations of type 2 diabetes mellitus on MRI: a pilot study","volume":"606","author":"Peng","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"2013","key":"10.1016\/j.neulet.2017.04.034_bib0065","first-page":"86693I","article-title":"Consistent 4D brain extraction of serial brain MR images","volume":"8669","author":"Wang","year":"2013","journal-title":"SPIE Med. Imag. Int. Soc. Opt. Photon."},{"issue":"7","key":"10.1016\/j.neulet.2017.04.034_bib0070","doi-asserted-by":"crossref","first-page":"e64207","DOI":"10.1371\/journal.pone.0064207","article-title":"4D segmentation of brain MR images with constrained cortical thickness variation","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neulet.2017.04.034_bib0075","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1016\/j.neuroimage.2011.11.012","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative, Consistent reconstruction of cortical surfaces from longitudinal brain MR images","volume":"59","author":"Li","year":"2012","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neulet.2017.04.034_bib0080","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neulet.2017.04.034_bib0085","doi-asserted-by":"crossref","first-page":"e77810","DOI":"10.1371\/journal.pone.0077810","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative, Knowledge-guided robust MRI brain extraction for diverse large-scale neuroimaging studies on humans and non-human primates","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.neulet.2017.04.034_bib0090","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1109\/TPAMI.2005.159","article-title":"Feature selection based on mutual information criteria of max-dependency, max-relevance, and min-redundancy","volume":"27","author":"Peng","year":"2005","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"issue":"3","key":"10.1016\/j.neulet.2017.04.034_bib0095","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1109\/TNB.2005.853657","article-title":"Multiple SVM-RFE for gene selection in cancer classification with expression data","volume":"4","author":"Duan","year":"2005","journal-title":"IEEE Trans. Nanobiosci."},{"issue":"5","key":"10.1016\/j.neulet.2017.04.034_bib0100","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1109\/TVCG.2006.147","article-title":"Hierarchical edge bundles: visualization of adjacency relations in hierarchical data","volume":"12","author":"Holten","year":"2006","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"issue":"2","key":"10.1016\/j.neulet.2017.04.034_bib0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/jnnp-2011-300828","article-title":"Grey matter atrophy in cognitively impaired Parkinson\u2019s disease","volume":"83","author":"Melzer","year":"2012","journal-title":"J. Neurol. Neurosurg. Psych."},{"issue":"2","key":"10.1016\/j.neulet.2017.04.034_bib0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.neuroimage.2010.12.043","article-title":"Patterns of cortical thickness and surface area in early Parkinson\u2019s disease","volume":"55","author":"Jubault","year":"2011","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neulet.2017.04.034_bib0115","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/mds.23477","article-title":"The pattern of cortical atrophy in patients with Parkinson\u2019s disease according to cognitive status","volume":"26","author":"Song","year":"2011","journal-title":"Mov. Disord."},{"issue":"99","key":"10.1016\/j.neulet.2017.04.034_bib0120","first-page":"1","article-title":"Multimodal neuroimaging feature learning with multimodal stacked deep polynomial networks for diagnosis of Alzheimer\u2019s disease","volume":"99","author":"Shi","year":"2017","journal-title":"IEEE J. Biomed. Health. Inf."},{"key":"10.1016\/j.neulet.2017.04.034_bib0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneumeth.2013.09.001","article-title":"Detecting brain structural changes as biomarker from magnetic resonance images using a local feature based SVM approach","volume":"221","author":"Chen","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2017.04.034_bib0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jneumeth.2013.11.016","article-title":"Machine learning on brain MRI data for differential diagnosis of Parkinson\u2019s disease and Progressive Supranuclear Palsy","volume":"222","author":"Salvatore","year":"2014","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.neulet.2017.04.034_bib0135","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1468-1331.2009.02807.x","article-title":"A deformation-based morphometry study of patients with early-stage Parkinson\u2019s disease","volume":"17","author":"Borghammer","year":"2010","journal-title":"Eur. J. Neurol."},{"issue":"5","key":"10.1016\/j.neulet.2017.04.034_bib0140","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/mds.20371","article-title":"Amygdalar and hippocampal MRI volumetric reductions in Parkinson\u2019s disease with dementia","volume":"20","author":"Junqu\u00e9","year":"2005","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.neulet.2017.04.034_bib0145","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/mds.22799","article-title":"Hippocampal, caudate, and ventricular changes in Parkinson\u2019s disease with and without dementia","volume":"25","author":"Apostolova","year":"2010","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.neulet.2017.04.034_bib0150","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/brain\/109.5.845","article-title":"Frontal lobe dysfunction in Parkinson\u2019s disease","volume":"109","author":"TAYLOR","year":"1986","journal-title":"Brain"},{"issue":"13","key":"10.1016\/j.neulet.2017.04.034_bib0155","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/mds.22680","article-title":"Temporal lobe changes in early, untreated Parkinson\u2019s disease","volume":"24","author":"Martin","year":"2009","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.neulet.2017.04.034_bib0160","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/archneur.1979.00500390062006","article-title":"Dominant language functions of the right hemisphere? Prosody and emotional gesturing","volume":"36","author":"Ross","year":"1979","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2017.04.034_bib0165","doi-asserted-by":"crossref","first-page":"e52602","DOI":"10.1371\/journal.pone.0052602","article-title":"Differential neural activation patterns in patients with Parkinson\u2019s disease and freezing of gait in response to concurrent cognitive and motor load","volume":"8","author":"Shine","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neulet.2017.04.034_bib0170","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/mds.26130","article-title":"Microstructural changes in white matter associated with freezing of gait in Parkinson\u2019s disease","volume":"30","author":"Vercruysse","year":"2015","journal-title":"Mov. Disord."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401730335X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401730335X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T10:50:44Z","timestamp":1535885444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439401730335X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":34,"alternative-id":["S030439401730335X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.04.034","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multilevel-ROI-features-based machine learning method for detection of morphometric biomarkers in Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}