{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:41Z","timestamp":1792787261733,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Rimvydas Jonikas for technical assistance performing experiments"},{"name":"Research Fund of Lithuanian University of Health Sciences","id":[{"id":"https:\/\/ror.org\/0069bkg23","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.neulet.2017.05.028","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T15:33:37Z","timestamp":1495035217000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains"],"prefix":"10.1016","volume":"653","author":[{"given":"Evelina","family":"Rekuviene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laima","family":"Ivanoviene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmante","family":"Borutaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramune","family":"Morkuniene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.05.028_bib0005","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00004647-199907000-00002","article-title":"Bockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion","volume":"19","author":"Matsumoto","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.05.028_bib0010","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0505294102","article-title":"Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia","volume":"102","author":"Schinzel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.05.028_bib0015","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1006\/jmcc.1993.1162","article-title":"Protection by Cyclosporin A of ischemia\/reperfusion-induced damage in isolated rat hearts","volume":"25","author":"Griffiths","year":"1993","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.neulet.2017.05.028_bib0020","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.neurobiolaging.2006.06.022","article-title":"Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition","volume":"28","author":"Eliseev","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2017.05.028_bib0025","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1523\/JNEUROSCI.20-22-08229.2000","article-title":"Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria","volume":"20","author":"Brustovetsky","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0030","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/0006-2952(93)90677-O","article-title":"Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein","volume":"46","author":"Tsuji","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2017.05.028_bib0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s004150050360","article-title":"Cyclosporine neurotoxicity: a review","volume":"246","author":"Gijtenbeek","year":"1999","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2017.05.028_bib0040","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1212\/WNL.0000000000001639","article-title":"Cyclosporine in acute ischemic stroke","volume":"84","author":"Nighoghossian","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2017.05.028_bib0045","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbabio.2012.05.011","article-title":"Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D","volume":"1817","author":"Li","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2017.05.028_bib0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.yjmcc.2012.11.023","article-title":"Synergistic protective effect of cyclosporin A and rotenone against hypoxia-reoxygenation in cardiomyocytes","volume":"56","author":"Teixeira","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.neulet.2017.05.028_bib0055","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.3390\/ijms13067694","article-title":"The role of PPAR\u03b1 in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia\/reperfusion in rats","volume":"13","author":"Barreto-Torres","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0060","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.febslet.2011.02.029","article-title":"Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore","volume":"585","author":"Chen","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neulet.2017.05.028_bib0065","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/jnc.12811","article-title":"Acute stress delays brain mitochondrial permeability transition pore opening","volume":"131","author":"Batandier","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.05.028_bib0070","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1471-4159.2006.04333.x","article-title":"Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease","volume":"100","author":"Sherer","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.05.028_bib0075","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0080","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00690397","article-title":"The density and distribution of ischemic brain injury in the rat following 2\u201310min of forebrain ischemia","volume":"64","author":"Smith","year":"1984","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2017.05.028_bib0085","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1111\/j.1471-4159.2007.04912.x","article-title":"Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition","volume":"103","author":"Morota","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.05.028_bib0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/neuro.09.031.2009","article-title":"The human brain in numbers: a linearly scaled-up primate brain","volume":"3","author":"Herculano-Houzel","year":"2009","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0095","unstructured":"E. Rekuviene, L. Ivanoviene, V. Borutaite, R. Morkuniene, Data on effects of rotenone on calcium retention capacity, activities of respiratory chain complexes I and II and respiration in isolated rat brain mitochondria, DIB-D-17-00433 Data in Brief submitted."},{"key":"10.1016\/j.neulet.2017.05.028_bib0100","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1111\/j.1742-4658.2005.04781.x","article-title":"Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia\/reoxygenation and low micromolar Ca2+","volume":"272","author":"Schild","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.neulet.2017.05.028_bib0105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2014.09.039","article-title":"Neuroprotective effects of gallic acid against hypoxia\/reoxygenation-induced mitochondrial dysfunctions in vitro and cerebral ischemia\/reperfusion injury in vivo","volume":"1589","author":"Sun","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.05.028_bib0110","doi-asserted-by":"crossref","first-page":"41394","DOI":"10.1074\/jbc.M106417200","article-title":"Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells","volume":"276","author":"Chauvin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.05.028_bib0115","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/BJ20040885","article-title":"Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study","volume":"382","author":"Guigas","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.neulet.2017.05.028_bib0120","first-page":"406","article-title":"Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release","volume":"77","author":"Aldakkak","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neulet.2017.05.028_bib0125","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1523\/JNEUROSCI.6303-11.2012","article-title":"The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice","volume":"32","author":"Niatsetskaya","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0130","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/febs.12086","article-title":"Reactive oxygen species are generated by the respiratory complex II-evidence for lack of contribution of the reverse electron flow in complex I","volume":"280","author":"Moreno-S\u00e1nchez","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.neulet.2017.05.028_bib0135","doi-asserted-by":"crossref","first-page":"17197","DOI":"10.1074\/jbc.M310329200","article-title":"Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I","volume":"279","author":"Batandier","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.05.028_bib0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004647-199802000-00011","article-title":"Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat","volume":"18","author":"Peters","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2017.05.028_bib0145","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jocn.2010.07.140","article-title":"Cerebral reactive oxygen species assessed by electron spin resonance spectroscopy in the initial stage of ischemia-reperfusion are not associated with hypothermic neuroprotection","volume":"18","author":"Kunimatsu","year":"2011","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.neulet.2017.05.028_bib0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroscience.2005.01.044","article-title":"Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration","volume":"133","author":"Diaz-Corrales","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.05.028_bib0155","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.bbamcr.2015.03.010","article-title":"Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2","volume":"1853","author":"Grefte","year":"2015","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017304160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017304160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T01:38:22Z","timestamp":1719193102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017304160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":31,"alternative-id":["S0304394017304160"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.05.028","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}