{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:59:47Z","timestamp":1783742387022,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200986"],"award-info":[{"award-number":["81200986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472160"],"award-info":[{"award-number":["81472160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313691"],"award-info":[{"award-number":["2015A030313691"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public Research and Capacity Building Project of Guangdong Province","award":["2014A020212036"],"award-info":[{"award-number":["2014A020212036"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.neulet.2017.07.019","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T14:31:16Z","timestamp":1501338676000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats"],"prefix":"10.1016","volume":"657","author":[{"given":"Wei-lan","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-guo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-sheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.07.019_bib0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molmed.2012.12.003","article-title":"Parkinson\u2019s disease in the nuclear age of neuroinflammation","volume":"19","author":"Nolan","year":"2013","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neulet.2017.07.019_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.neuro.28.061604.135718","article-title":"Molecular pathophysiology of Parkinson's disease","volume":"28","author":"Moore","year":"2005","journal-title":"Annual. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.07.019_bib0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/jnp.14.2.223","article-title":"An essay on the shaking palsy. 1817","volume":"14","author":"Parkinson","year":"2002","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.neulet.2017.07.019_bib0020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in Parkinson's disease","volume":"139","author":"Bose","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.07.019_bib0025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1001\/archneur.62.3.353","article-title":"Molecular pathogenesis of Parkinson disease","volume":"62","author":"Eriksen","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0030","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10863-009-9257-z","article-title":"The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease","author":"Hastings","year":"2009","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.neulet.2017.07.019_bib0035","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1177\/1535370215576313","article-title":"Parkinson's disease and enhanced inflammatory response","volume":"40","author":"Stojkovska","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neulet.2017.07.019_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ics.12287","article-title":"Oxidative stress-A key emerging impact factor in health ageing, lifestyle and aesthetics","volume":"37","author":"Kandola","year":"2015","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.neulet.2017.07.019_bib0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.biopha.2016.09.055","article-title":"Neuroprotective effects of Caralluma tuberculata on ameliorating cognitive impairment in a d-galactose-induced mouse model","volume":"23","author":"Khan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neulet.2017.07.019_bib0050","first-page":"157","article-title":"The role for oxidative stress in neurodegenerative diseases","volume":"60","author":"Shibata","year":"2008","journal-title":"Brain Nerve"},{"key":"10.1016\/j.neulet.2017.07.019_bib0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI200317638","article-title":"Oxidative stress and nitration in neurodegeneration: cause effect, or association?","volume":"111","author":"Ischiropoulos","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2017.07.019_bib0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease and monogenic parkinsonism","volume":"51","author":"Hauser","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2017.07.019_bib0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson\u2019s disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0075","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company three\u2019s a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2017.07.019_bib0080","first-page":"4","article-title":"Hydrogen sulfide (H2S) \u2212 the third gas of interest for pharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neulet.2017.07.019_bib0085","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neulet.2017.07.019_bib0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2017.07.019_bib0095","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.07.019_bib0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1096\/fj.03-1052fje","article-title":"Hydrogen sulfide induces calcium waves in astrocytes","volume":"18","author":"Nagai","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2017.07.019_bib0105","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2017.07.019_bib0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.lfs.2009.05.023","article-title":"Hydrogen sulfide inhibits MPP(+)-induced apoptosis in PC12 cells","volume":"85","author":"Yin","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2017.07.019_bib0115","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Moore PK, Bian JS, Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.07.019_bib0120","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.freeradbiomed.2008.09.014","article-title":"Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake","volume":"45","author":"Lu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2017.07.019_bib0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","article-title":"Neuroprotective effects of hydrogen sulfide on Parkinson\u2019s disease rat models","volume":"9","author":"Lu","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.neulet.2017.07.019_bib0130","first-page":"4","article-title":"Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists","volume":"59","author":"Lowicka","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neulet.2017.07.019_bib0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids."},{"key":"10.1016\/j.neulet.2017.07.019_bib0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA\uff0cdopamine and MPTP\uff1acontribution to the apoptotic theory in Parkinson\u2019s disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0145","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00441-004-0937-z","article-title":"Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration","volume":"318","author":"Uversky","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2017.07.019_bib0150","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1602\/neurorx.2.3.484","article-title":"Toxin-induced models of Parkinson's disease","volume":"2","author":"Bove","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.neulet.2017.07.019_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11064-008-9656-2","article-title":"Oxidative and inflammatory pathways in Parkinson\u2019s disease","volume":"34","author":"Miller","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2017.07.019_bib0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","article-title":"Identification of two distinct synucleins from human brain","volume":"345","author":"Jakes","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neulet.2017.07.019_bib0165","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.07.019_bib0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/35041081","article-title":"Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?","volume":"2","author":"Goldberg","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0175","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuropharm.2013.05.025","article-title":"Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of \u03b1-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL\/6J mice","volume":"73","author":"Sathiya","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2017.07.019_bib0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2015.11.057","article-title":"Pharmacological evidence that NaHS inhibits the vasopressor responses induced by stimulation of the preganglionic sympathetic outflow in pithed rats","volume":"770","author":"Centurion","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2017.07.019_bib0185","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.neulet.2017.07.019_bib0190","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.micinf.2003.10.009","article-title":"Expression of small hairpinRNA by lentivirus-based vector confers efficient and stable gene suppression of HIV-1 on human cells including primary nondividingcells","volume":"6","author":"Nishitujli","year":"2004","journal-title":"Microbes Infect."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017305815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017305815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T16:15:27Z","timestamp":1569946527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017305815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":38,"alternative-id":["S0304394017305815"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.07.019","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}