{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:24:16Z","timestamp":1760171056463,"version":"3.37.3"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS064193","NS092926"],"award-info":[{"award-number":["NS064193","NS092926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"crossref","award":["IBX002823"],"award-info":[{"award-number":["IBX002823"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neulet.2017.08.066","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T13:45:51Z","timestamp":1504273551000},"page":"44-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Sleep-inducing effect of substance P-cholera toxin A subunit in mice"],"prefix":"10.1016","volume":"659","author":[{"given":"Mark R.","family":"Zielinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Gerashchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.08.066_bib0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1054\/npep.2000.0834","article-title":"Neuroanatomical localisation of substance P in the CNS and sensory neurons","volume":"34","author":"Ribeiro-da-Silva","year":"2000","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neulet.2017.08.066_bib0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/physrev.1993.73.2.229","article-title":"Neurotransmitter functions of mammalian tachykinins","volume":"73","author":"Otsuka","year":"1993","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2017.08.066_bib0015","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1097\/00001756-199912160-00044","article-title":"Serotonin and substance P co-exist in dorsal raphe neurons of the human brain","volume":"10","author":"Sergeyev","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2017.08.066_bib0020","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1046\/j.1440-1681.2000.03366.x","article-title":"Localization of tachykinin receptors and Fos-like immunoreactivity induced by substance P in guinea-pig brain","volume":"27","author":"Yip","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neulet.2017.08.066_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4179(98)90015-4","article-title":"The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles","volume":"32","author":"Quartara","year":"1998","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neulet.2017.08.066_bib0030","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3174\/ajnr.A1073","article-title":"Multiphase CT angiography versus single-phase CT angiography: comparison of image quality and radiation dose","volume":"29","author":"Yang","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neulet.2017.08.066_bib0035","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jpain.2010.05.007","article-title":"Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin","volume":"11","author":"Caudle","year":"2010","journal-title":"J. Pain"},{"key":"10.1016\/j.neulet.2017.08.066_bib0040","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbr.2005.09.008","article-title":"Sleep disturbance induced by substance P in mice","volume":"167","author":"Andersen","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2017.08.066_bib0045","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0893-133X(02)00369-X","article-title":"Effects of the neuropeptide substance p on sleep, mood, and neuroendocrine measures in healthy young men","volume":"27","author":"Lieb","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2017.08.066_bib0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.brainres.2004.09.017","article-title":"Substance P promotes sleep in the ventrolateral preoptic area of rats","volume":"1028","author":"Zhang","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.08.066_bib0055","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuroscience.2014.08.062","article-title":"Substance P and the neurokinin-1 receptor regulate electroencephalogram non-rapid eye movement sleep slow-wave activity locally","volume":"284","author":"Zielinski","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.08.066_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1744-8069-10-73","article-title":"Characteristics of dorsal root ganglia neurons sensitive to Substance P","volume":"10","author":"Moraes","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neulet.2017.08.066_bib0065","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1091\/mbc.9.8.2305","article-title":"Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq\/11, G-protein receptor kinase-2\/3, and beta-arrestin-1\/2","volume":"9","author":"McConalogue","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neulet.2017.08.066_bib0070","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/252734a0","article-title":"Excitatory action of hypothalamic substance P on spinal motoneurones of newborn rats","volume":"252","author":"Konishi","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.08.066_bib0075","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0361-9230(93)90261-9","article-title":"Interactions between excitatory amino acids and tachykinins in the rat spinal dorsal horn","volume":"30","author":"Rusin","year":"1993","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2017.08.066_bib0080","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/315498a0","article-title":"P raises neuronal membrane excitability by reducing inward rectification","volume":"315","author":"Stanfield","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.08.066_bib0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(93)90374-T","article-title":"Chemosensitivity of C-cells in bullfrog dorsal root ganglia to substance P and adenosine 5'-triphosphate","volume":"163","author":"Tokimasa","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.08.066_bib0090","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1749-6632.1991.tb33110.x","article-title":"Substance P actions on sensory neurons","volume":"632","author":"Spigelman","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2017.08.066_bib0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0306-4522(92)90428-5","article-title":"Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons","volume":"50","author":"Shen","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.08.066_bib0100","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/jn.1998.79.2.769","article-title":"Substance P regulates Ih via a NK-1 receptor in vagal sensory neurons of the ferret","volume":"79","author":"Jafri","year":"1998","journal-title":"J. Neurophysiol."},{"issue":"Pt. 1","key":"10.1016\/j.neulet.2017.08.066_bib0105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1113\/jphysiol.1996.sp021371","article-title":"Substance P hyperpolarizes vagal sensory neurones of the ferret","volume":"493","author":"Jafri","year":"1996","journal-title":"J. Physiol"},{"key":"10.1016\/j.neulet.2017.08.066_bib0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/jn.00108.2003","article-title":"Protein kinase C is involved in neurokinin receptor modulation of N- and L-type Ca2+ channels in DRG neurons of the adult rat","volume":"90","author":"Sculptoreanu","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2017.08.066_bib0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1744-8069-1-34","article-title":"Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P","volume":"1","author":"Wu","year":"2005","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neulet.2017.08.066_bib0120","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2202-8-30","article-title":"Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin","volume":"8","author":"Caudle","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neulet.2017.08.066_bib0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbi.2017.01.012","article-title":"The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide","volume":"62","author":"Zielinski","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2017.08.066_bib0130","first-page":"187","article-title":"Substance P and primary afferent transmission","volume":"15","author":"Otsuka","year":"1976","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"10.1016\/j.neulet.2017.08.066_bib0135","doi-asserted-by":"crossref","first-page":"10167","DOI":"10.1523\/JNEUROSCI.1809-08.2008","article-title":"Neural circuitry of stress-induced insomnia in rats","volume":"28","author":"Cano","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.08.066_bib0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0306-3623(97)00078-5","article-title":"Neurogenic vasodilatation and plasma leakage in the skin","volume":"30","author":"Holzer","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.neulet.2017.08.066_bib0145","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0028-3908(00)00171-4","article-title":"Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E(2) from isolated rat skin","volume":"40","author":"Averbeck","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2017.08.066_bib0150","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1159\/000363041","article-title":"Activation of microglia by histamine and substance P","volume":"34","author":"Zhu","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.neulet.2017.08.066_bib0155","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3892\/ijmm.2017.2875","article-title":"Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma\/astrocytoma cells","volume":"39","author":"Yamaguchi","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neulet.2017.08.066_bib0160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3934\/Neuroscience.2016.1.67","article-title":"Functions and mechanisms of sleep","volume":"31","author":"Zielinski","year":"2016","journal-title":"AIMS Neurosci."},{"key":"10.1016\/j.neulet.2017.08.066_bib0165","series-title":"Diet and Exercise in Cognitive Function and Neurological Diseases","first-page":"225","article-title":"Role of sleep in cognition, immunity, and disease and its interaction with exercise","author":"Zielinski","year":"2015"},{"key":"10.1016\/j.neulet.2017.08.066_bib0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-444-53839-0.00003-X","article-title":"Involvement of cytokines in slow wave sleep","volume":"193","author":"Krueger","year":"2011","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neulet.2017.08.066_bib0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fncir.2012.00031","article-title":"Cortical nNOS neurons co-express the NK1 receptor and are depolarized by substance P in multiple mammalian species","volume":"6","author":"Dittrich","year":"2012","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neulet.2017.08.066_bib0180","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0306-4522(02)00748-0","article-title":"Autoradiographic distribution of tachykinin NK2 binding sites in the rat brain: comparison with NK1 and NK3 binding sites","volume":"116","author":"Saffroy","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.08.066_bib0185","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.5665\/sleep.3208","article-title":"Efficacy of vestipitant, a neurokinin-1 receptor antagonist, in primary insomnia","volume":"36","author":"Ratti","year":"2013","journal-title":"Sleep"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017307267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017307267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:25:09Z","timestamp":1536121509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017307267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":37,"alternative-id":["S0304394017307267"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.08.066","relation":{},"ISSN":["0304-3940"],"issn-type":[{"type":"print","value":"0304-3940"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep-inducing effect of substance P-cholera toxin A subunit in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.08.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}