{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:07:57Z","timestamp":1773806877395,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neulet.2017.08.067","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T16:37:10Z","timestamp":1504283830000},"page":"14-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus"],"prefix":"10.1016","volume":"659","author":[{"given":"B\u00e1rbara de Almeida","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Keine","family":"Kuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor Rosetto","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Calais","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Rosolen","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Diego","family":"Botezelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelino Sanchez Ramos","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennys Esper","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Pereira","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Moreira","family":"Simabuco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Rochete","family":"Ropelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Rodrigo","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.08.067_bib0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/en.2011-1635","article-title":"Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance","volume":"153","author":"Kim","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2017.08.067_bib0010","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/EJE-15-1207","article-title":"MECHANISMS IN ENDOCRINOLOGY: hypothalamic inflammation and nutrition","volume":"175","author":"Araujo","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.neulet.2017.08.067_bib0015","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1210\/en.2014-1660","article-title":"The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice","volume":"156","author":"Muta","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2017.08.067_bib0020","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nn1731","article-title":"Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis","volume":"9","author":"Kim","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.08.067_bib0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nm1392","article-title":"Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake","volume":"12","author":"Kitamura","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2017.08.067_bib0030","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1074\/jbc.M808490200","article-title":"Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation","volume":"284","author":"Jurek","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.08.067_bib0035","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1113\/jphysiol.2013.264002","article-title":"Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice","volume":"592","author":"Pauli","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2017.08.067_bib0040","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1172\/JCI43250","article-title":"MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice","volume":"120","author":"Wu","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2017.08.067_bib0045","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1742-4658.2012.08716.x","article-title":"Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling","volume":"280","author":"Caunt","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.neulet.2017.08.067_bib0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mce.2012.03.025","article-title":"MEK\/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells","volume":"361","author":"Feng","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neulet.2017.08.067_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2014.05.039","article-title":"Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro","volume":"575","author":"Ndong","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.08.067_bib0060","doi-asserted-by":"crossref","first-page":"e41168","DOI":"10.1371\/journal.pone.0041168","article-title":"Mapping MKP-3\/FOXO1 interaction and evaluating the effect on gluconeogenesis","volume":"7","author":"Jiao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2017.08.067_bib0065","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.2337\/db14-0066","article-title":"Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity","volume":"63","author":"Feng","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.neulet.2017.08.067_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000465","article-title":"IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition","volume":"8","author":"Ropelle","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neulet.2017.08.067_bib0075","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1038\/ncomms5859","article-title":"Hypothalamic S1P\/S1PR1 axis controls energy homeostasis","volume":"5","author":"Silva","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2017.08.067_bib0080","article-title":"Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice","author":"Mu\u00f1oz","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.neulet.2017.08.067_bib0085","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1249\/MSS.0000000000000585","article-title":"Acute exercise decreases tribbles homolog 3 protein levels in the hypothalamus of obese rats","volume":"47","author":"RODRIGUES","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.neulet.2017.08.067_bib0090","doi-asserted-by":"crossref","first-page":"36013","DOI":"10.1074\/jbc.M508027200","article-title":"Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells","volume":"280","author":"Xu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.08.067_bib0095","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1172\/JCI62848","article-title":"FOXO1 in the ventromedial hypothalamus regulates energy balance","volume":"122","author":"Kim","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2017.08.067_bib0100","doi-asserted-by":"crossref","first-page":"E787","DOI":"10.1152\/ajpendo.00512.2009","article-title":"PDK-1\/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake","volume":"298","author":"Iskandar","year":"2010","journal-title":"AJP Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2017.08.067_bib0105","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1113\/jphysiol.2009.170050","article-title":"Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats","volume":"587","author":"Ropelle","year":"2009","journal-title":"J. Physiol."},{"issue":"February (2)","key":"10.1016\/j.neulet.2017.08.067_bib0110","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/ijo.2016.174","volume":"41","author":"Quaresma","year":"2017","journal-title":"Int J Obes (Lond)"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017307279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017307279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:25:12Z","timestamp":1536121512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017307279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":22,"alternative-id":["S0304394017307279"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.08.067","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.08.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}