{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:56:41Z","timestamp":1771268201464,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.neulet.2017.10.040","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T13:32:09Z","timestamp":1508506329000},"page":"242-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Increased level of procalcitonin is associated with total MRI burden of cerebral small vessel disease in patients with ischemic stroke"],"prefix":"10.1016","volume":"662","author":[{"given":"Guangzong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.10.040_bib0005","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/STROKEAHA.115.009627","article-title":"Emerging evidence for pathogenesis of sporadic cerebral small vessel disease","volume":"47","author":"Ihara","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.07.010","article-title":"Cognitive consequences of multiple lacunes and leukoaraiosis as vascular cognitive impairment in community-dwelling elderly individuals","volume":"18","author":"Koga","year":"2009","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.neulet.2017.10.040_bib0025","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1136\/jnnp.2003.030858","article-title":"Enlarged perivascular spaces are associated with cognitive function in healthy elderly men","volume":"75","author":"MacLullich","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2017.10.040_bib0030","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.neurobiolaging.2015.06.024","article-title":"Total MRI load of cerebral small vessel disease and cognitive ability in older people","volume":"36","author":"Staals","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2017.10.040_bib0035","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/ene.13213","article-title":"Total magnetic resonance imaging burden of cerebral small-vessel disease is associated with post-stroke depression in patients with acute lacunar stroke","volume":"24","author":"Zhang","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0040","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/jnnp.2009.175372","article-title":"Microbleeds and post-stroke emotional lability, Journal of Neurology","volume":"80","author":"Tang","year":"2009","journal-title":"Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2017.10.040_bib0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3988\/jcn.2017.13.2.187","article-title":"Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke","volume":"13","author":"Song","year":"2017","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1001\/jamaneurol.2014.3958","article-title":"Cerebral microbleeds and early recurrent stroke after transient ischemic attack: results from the Korean Transient Ischemic Attack Expression Registry","volume":"72","author":"Lim","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0055","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00003246-200004000-00011","article-title":"Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit","volume":"28","author":"M\u00fcller","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.neulet.2017.10.040_bib0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/0003319716657259","article-title":"Procalcitonin as a new indicator of inflammation","volume":"68","author":"Ertem","year":"2017","journal-title":"Angiology"},{"key":"10.1016\/j.neulet.2017.10.040_bib0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jns.2015.03.032","article-title":"Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke","volume":"352","author":"Li","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2017.10.040_bib0070","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10571-014-0131-0","article-title":"Relationship between procalcitonin serum levels and functional outcome in stroke patients","volume":"35","author":"Deng","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2017.10.040_bib0075","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s12035-015-9112-7","article-title":"Procalcitonin is a stronger predictor of long-term functional outcome and mortality than high-sensitivity C-reactive protein in patients with ischemic stroke","volume":"53","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.neulet.2017.10.040_bib0080","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1161\/STROKEAHA.115.011392","article-title":"Procalcitonin and midregional proatrial natriuretic peptide as markers of ischemic stroke","volume":"47","author":"Katan","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0085","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1212\/WNL.0000000000000837","article-title":"Stroke subtype vascular risk factors, and total MRI brain small-vessel disease burden","volume":"83","author":"Staals","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2017.10.040_bib0090","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1161\/STROKEAHA.114.008155","article-title":"Chronic kidney disease in patients with lacunar stroke. Association with enlarged perivascular spacesand total magnetic resonance imaging burdenof cerebral small vessel disease","volume":"46","author":"Xiao","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0095","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jns.2013.07.2513","article-title":"Microbleeds in ischemic stroke are associated with lower serumadiponectin and higher soluble E-selectin levels","volume":"334","author":"Huang","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2017.10.040_bib0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.53.1.126","article-title":"Baseline NIH stroke scale score strongly predicts outcome after stroke a report of the trial of org 10172 in acute stroke treatment (TOAST)","volume":"53","author":"Adams","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2017.10.040_bib0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.ajkd.2011.02.393","article-title":"GFR estimating equations in a multiethnic Asian population","volume":"58","author":"Teo","year":"2011","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.neulet.2017.10.040_bib0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in acute stroke treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0115","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1161\/STROKEAHA.113.002545","article-title":"Ambulatory blood pressure in patients with lacunar stroke. Association with total MRI burden of cerebral small vessel disease","volume":"44","author":"Klarenbeek","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fnagi.2013.00072","article-title":"Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients","volume":"5","author":"Huijts","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neulet.2017.10.040_bib0125","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MCC.0b013e328363bd38","article-title":"Using procalcitonin-guided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis","volume":"19","author":"Schuetz","year":"2013","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.neulet.2017.10.040_bib0130","first-page":"396","article-title":"Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis","volume":"86","author":"M\u00fcller","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2017.10.040_bib0135","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1210\/jc.2002-021444","article-title":"Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors","volume":"89","author":"Becker","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2017.10.040_bib0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-2143(99)90053-7","article-title":"Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro","volume":"134","author":"Oberhoffer","year":"1999","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.neulet.2017.10.040_bib0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s001340050543","article-title":"Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome","volume":"24","author":"Mimoz","year":"1998","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.neulet.2017.10.040_bib0150","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1212\/WNL.0b013e31824e8e7f","article-title":"Staging and natural history of cerebrovascular pathology in dementia","volume":"78","author":"Deramecourt","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2017.10.040_bib0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.STR.28.3.491","article-title":"Comparable studies of the incidence of stroke and its pathological types","volume":"28","author":"Sudlow","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2017.10.040_bib0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnagi.2014.00024","article-title":"Current pathophysiological concepts in cerebral small vessel disease","volume":"6","author":"Rincon","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neulet.2017.10.040_bib0165","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/00003246-200205000-00025","article-title":"Migration of human monocytes in response to procalcitonin","volume":"30","author":"Wiedermann","year":"2002","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.neulet.2017.10.040_bib0170","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/01.CCM.0000134404.63292.71","article-title":"Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes","volume":"32","author":"Linscheid","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.neulet.2017.10.040_bib0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2014.11.012","article-title":"Sepsis biomarker","volume":"440","author":"Prucha","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neulet.2017.10.040_bib0180","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.neurobiolaging.2011.04.008","article-title":"Vascular inflammation in cerebral small vessel disease","volume":"23","author":"Rouhl","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2017.10.040_bib0185","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/hr.2015.4","article-title":"Endothelial dysfunction is associated with the severity of cerebral small vessel disease","volume":"38","author":"Nezu","year":"2015","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.neulet.2017.10.040_bib0190","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/brain\/awh023","article-title":"Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction","volume":"127","author":"Hassan","year":"2004","journal-title":"Brain"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017308662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017308662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:27:57Z","timestamp":1536121677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017308662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"alternative-id":["S0304394017308662"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.10.040","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased level of procalcitonin is associated with total MRI burden of cerebral small vessel disease in patients with ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}