{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:41:40Z","timestamp":1789911700794,"version":"4.0.1"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["CALI_SID16_01"],"award-info":[{"award-number":["CALI_SID16_01"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["CPDA153402"],"award-info":[{"award-number":["CPDA153402"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["GRIC128SP0"],"award-info":[{"award-number":["GRIC128SP0"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RBSI14C65Z"],"award-info":[{"award-number":["RBSI14C65Z"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.neulet.2017.11.005","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T05:15:32Z","timestamp":1511154932000},"page":"2-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["The PMCA pumps in genetically determined neuronal pathologies"],"prefix":"10.1016","volume":"663","author":[{"given":"Tito","family":"Cal\u00ec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Brini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Carafoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.11.005_bib0005","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajhg.2014.07.007","article-title":"Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy","volume":"95","author":"Aldinger","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0896-6273(03)00639-1","article-title":"Local calcium signaling in neurons","volume":"40","author":"Augustine","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2017.11.005_bib0015","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/infdis\/jit070","article-title":"An ATP2B4 polymorphism protects against malaria in pregnancy","volume":"207","author":"Bedu-Addo","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.neulet.2017.11.005_bib0020","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0025","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/scdb.2000.0211","article-title":"Calcium signalling\u2013an overview","volume":"12","author":"Bootman","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0035","doi-asserted-by":"crossref","first-page":"37693","DOI":"10.1074\/jbc.M110.170092","article-title":"The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice","volume":"285","author":"Bortolozzi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0040","doi-asserted-by":"crossref","first-page":"41619","DOI":"10.1074\/jbc.M403116200","article-title":"Loss of autoinhibition of the plasma membrane Ca(2+) pump by substitution of aspartic 170 by asparagin. Activation of plasma membrane calcium ATPase 4 without disruption of the interaction between the catalytic core and the C-terminal regulatory domain","volume":"279","author":"Bredeston","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0045","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/physrev.00032.2008","article-title":"Calcium pumps in health and disease","volume":"89","author":"Brini","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2017.11.005_bib0050","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.bbrc.2016.07.117","article-title":"The plasma membrane calcium pumps: focus on the role in (neuro)pathology","volume":"483","author":"Brini","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2017.11.005_bib0055","doi-asserted-by":"crossref","first-page":"24500","DOI":"10.1074\/jbc.M300784200","article-title":"A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells","volume":"278","author":"Brini","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0060","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1432-1033.1992.tb16715.x","article-title":"Identification of two domains which mediate the binding of activating phospholipids to the plasma-membrane Ca2+ pump","volume":"204","author":"Brodin","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/cne.10933","article-title":"Isoform-specific distribution of the plasma membrane Ca2+ ATPase in the rat brain","volume":"467","author":"Burette","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0070","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/cne.21237","article-title":"Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex","volume":"500","author":"Burette","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0075","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.ircmb.2017.01.002","article-title":"Regulation of cell calcium and role of plasma membrane calcium ATPases","volume":"332","author":"Cali","year":"2017","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0080","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbadis.2016.09.007","article-title":"The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process","volume":"1863","author":"Cali","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2017.11.005_bib0085","doi-asserted-by":"crossref","first-page":"16132","DOI":"10.1074\/jbc.M115.656496","article-title":"A novel mutation in isoform 3 of the plasma membrane Ca2+ pump impairs cellular Ca2+ homeostasis in a patient with cerebellar ataxia and laminin subunit 1alpha mutations","volume":"290","author":"Cali","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"40","key":"10.1016\/j.neulet.2017.11.005_bib0090","doi-asserted-by":"crossref","first-page":"20849","DOI":"10.1074\/jbc.R116.735894","article-title":"Why calcium? How calcium became the best communicator","volume":"291","author":"Carafoli","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1054\/ceca.2001.0212","article-title":"Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells","volume":"30","author":"Caride","year":"2001","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neulet.2017.11.005_bib0100","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/S0021-9258(19)69600-6","article-title":"The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification","volume":"256","author":"Caroni","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0105","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1016\/S0021-9258(19)68765-X","article-title":"Regulation of Ca2+-pumping ATPase of heart sarcolemma by a phosphorylation-dephosphorylation process","volume":"256","author":"Caroni","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0110","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceca.2006.08.021","article-title":"Calcium microdomains and gene expression in neurons and skeletal muscle cells","volume":"40","author":"Carrasco","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neulet.2017.11.005_bib0115","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1111\/j.1460-9568.2012.08159.x","article-title":"The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells","volume":"36","author":"Chen","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0120","doi-asserted-by":"crossref","first-page":"18464","DOI":"10.1074\/jbc.M301482200","article-title":"Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting","volume":"278","author":"Chicka","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0125","first-page":"176","article-title":"Modeling the cerebellar microcircuit: new strategies for a long-standing issue","volume":"10","author":"D'Angelo","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrn3011","article-title":"Spatiotemporal firing patterns in the cerebellum","volume":"12","author":"De Zeeuw","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrn2756","article-title":"The cerebellar microcircuit as an adaptive filter: experimental and computational evidence","volume":"11","author":"Dean","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0169-328X(94)00231-3","article-title":"Localization of the plasma membrane Ca(2+)-ATPase isoform PMCA3 in rat cerebellum, choroid plexus and hippocampus","volume":"29","author":"Eakin","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0145","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ng.3667","article-title":"The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals","volume":"48","author":"Ehret","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0150","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1016\/S0021-9258(18)45587-1","article-title":"The maximal velocity and the calcium affinity of the red cell calcium pump may be regulated independently","volume":"262","author":"Enyedi","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0155","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1016\/S0021-9258(18)49937-1","article-title":"The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain","volume":"266","author":"Falchetto","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0160","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/pro.5560011209","article-title":"The calmodulin-binding site of the plasma membrane Ca2+ pump interacts with the transduction domain of the enzyme","volume":"1","author":"Falchetto","year":"1992","journal-title":"Protein Sci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0165","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jacc.2013.01.103","article-title":"Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort)","volume":"62","author":"Ferguson","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0170","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/mds.26800","article-title":"Dystonia in ATP2B3-associated X-linked spinocerebellar ataxia","volume":"31","author":"Feyma","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2017.11.005_bib0175","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0609775104","article-title":"A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness","volume":"104","author":"Ficarella","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.005_bib0180","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1242\/dmm.022848","article-title":"Spontaneous shaker rat mutant \u2013 a new model for X-linked tremor\/ataxia","volume":"9","author":"Figueroa","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neulet.2017.11.005_bib0185","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1083\/jcb.120.5.1147","article-title":"Calcium pump of the plasma membrane is localized in caveolae","volume":"120","author":"Fujimoto","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0190","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1432-1033.1994.00873.x","article-title":"Phospholipids are necessary for calmodulin-stimulated activation of the Ca(2+)-ATPase of erythrocytes","volume":"224","author":"Gazzotti","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0195","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/01.RES.0000092142.19896.D9","article-title":"Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure","volume":"93","author":"Gros","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0200","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.RES.83.9.877","article-title":"Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats","volume":"83","author":"Hammes","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0205","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1523\/JNEUROSCI.4547-13.2014","article-title":"Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity","volume":"34","author":"Heiney","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0210","doi-asserted-by":"crossref","first-page":"e00321","DOI":"10.1002\/brb3.321","article-title":"PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion","volume":"5","author":"Ho","year":"2015","journal-title":"Brain Behav."},{"key":"10.1016\/j.neulet.2017.11.005_bib0215","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1016\/S0021-9258(18)82197-4","article-title":"The C-terminal domain of the plasma membrane Ca2+ pump contains three high affinity Ca2+ binding sites","volume":"268","author":"Hofmann","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0220","doi-asserted-by":"crossref","first-page":"e5775","DOI":"10.1371\/journal.pone.0005775","article-title":"Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis","volume":"4","author":"Hu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2017.11.005_bib0225","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2170\/jjphysiol.34.781","article-title":"The modifiable neuronal network of the cerebellum","volume":"34","author":"Ito","year":"1984","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0230","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nrn962","article-title":"The molecular organization of cerebellar long-term depression","volume":"3","author":"Ito","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0235","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1016\/S0021-9258(18)69154-9","article-title":"Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes","volume":"263","author":"James","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0240","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1016\/S0021-9258(18)83181-7","article-title":"Modulation of erythrocyte Ca2+-ATPase by selective calpain cleavage of the calmodulin-binding domain","volume":"264","author":"James","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0245","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1073\/pnas.1516138113","article-title":"PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer","volume":"113","author":"Jeong","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.005_bib0250","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1471-4159.2007.04480.x","article-title":"Partitioning of the plasma membrane Ca2+-ATPase into lipid rafts in primary neurons: effects of cholesterol depletion","volume":"102","author":"Jiang","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0255","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1523\/JNEUROSCI.4202-06.2007","article-title":"Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace","volume":"27","author":"Jirenhed","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0260","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng.834","article-title":"Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians","volume":"43","author":"Kato","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0265","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1016\/S0021-9258(18)53836-9","article-title":"Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4","volume":"268","author":"Keeton","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0270","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/jc.2015-3284","article-title":"Clinical and steroidogenic characteristics of aldosterone-producing adenomas with ATPase or CACNA1D gene mutations","volume":"101","author":"Kitamoto","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2017.11.005_bib0275","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1161\/HYPERTENSIONAHA.110.165068","article-title":"Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation","volume":"59","author":"Kobayashi","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.neulet.2017.11.005_bib0280","doi-asserted-by":"crossref","first-page":"18693","DOI":"10.1074\/jbc.273.30.18693","article-title":"Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2","volume":"273","author":"Kozel","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0285","first-page":"129","article-title":"New mutants and linkages: deafwaddler (dfw)","volume":"77","author":"Lane","year":"1987","journal-title":"Mouse News Lett."},{"key":"10.1016\/j.neulet.2017.11.005_bib0290","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ng.384","article-title":"Genome-wide association study of blood pressure and hypertension","volume":"41","author":"Levy","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0295","doi-asserted-by":"crossref","first-page":"e104790","DOI":"10.1371\/journal.pone.0104790","article-title":"PMCA4 (ATP2B4) mutation in familial spastic paraplegia","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2017.11.005_bib0300","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1074\/jbc.O114.555565","article-title":"The plasma membrane calcium pump: new ways to look at an old enzyme","volume":"289","author":"Lopreiato","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0305","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/ng.2337","article-title":"Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease","volume":"44","author":"Lu","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0310","doi-asserted-by":"crossref","first-page":"R522","DOI":"10.1016\/S0960-9822(00)00584-4","article-title":"Cerebellar function: coordination learning or timing?","volume":"10","author":"Mauk","year":"2000","journal-title":"Curr. Biol."},{"issue":"Suppl. 3","key":"10.1016\/j.neulet.2017.11.005_bib0315","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/81486","article-title":"Computer simulation of cerebellar information processing","author":"Medina","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0320","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1038\/ncomms11074","article-title":"The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy","volume":"7","author":"Mohamed","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2017.11.005_bib0325","doi-asserted-by":"crossref","first-page":"41520","DOI":"10.1074\/jbc.M111.290411","article-title":"Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain","volume":"286","author":"Mohamed","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0330","doi-asserted-by":"crossref","first-page":"217","DOI":"10.18433\/J3PG68","article-title":"Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump\u2013a novel therapeutic target for contraception and malaria","volume":"16","author":"Mohamed","year":"2013","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0335","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.3799-04.2005","article-title":"Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons","volume":"25","author":"Muller","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0340","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ceb.2008.06.004","article-title":"Cadherins and mechanotransduction by hair cells","volume":"20","author":"Muller","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0345","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1016\/S0021-9258(19)68885-X","article-title":"Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ \u2013 ATPase","volume":"256","author":"Niggli","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0350","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M404628200","article-title":"Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4","volume":"279","author":"Okunade","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0355","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1113\/jphysiol.2008.153460","article-title":"Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function","volume":"586","author":"Parekh","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0360","doi-asserted-by":"crossref","first-page":"ra19","DOI":"10.1126\/scisignal.2005672","article-title":"Plasma membrane Ca(2)(+)-ATPases can shape the pattern of Ca(2)(+) transients induced by store-operated Ca(2)(+) entry","volume":"8","author":"Paszty","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neulet.2017.11.005_bib0365","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0968-0004(87)90071-5","article-title":"Ion motive ATPases. I. Ubiquity, properties and significance to cell function","volume":"12","author":"Pedersen","year":"1987","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0370","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5955(01)00356-2","article-title":"Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase 2","volume":"162","author":"Penheiter","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0375","doi-asserted-by":"crossref","first-page":"25505","DOI":"10.1038\/srep25505","article-title":"The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin","volume":"6","author":"Peters","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2017.11.005_bib0380","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/hr.2010.278","article-title":"Novel genetic variations associated with salt sensitivity in the Korean population","volume":"34","author":"Rhee","year":"2011","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0385","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.nbd.2010.11.014","article-title":"Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice","volume":"41","author":"Rozkalne","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2017.11.005_bib0390","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1073\/pnas.92.5.1759","article-title":"Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor","volume":"92","author":"Schnitzer","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.005_bib0395","doi-asserted-by":"crossref","first-page":"28220","DOI":"10.1074\/jbc.M312599200","article-title":"Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility","volume":"279","author":"Schuh","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0400","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa043899","article-title":"Modification of human hearing loss by plasma-membrane calcium pump PMCA2","volume":"352","author":"Schultz","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2017.11.005_bib0405","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/sj.cdd.4401042","article-title":"Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis","volume":"9","author":"Schwab","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2017.11.005_bib0410","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1074\/jbc.M506950200","article-title":"The plasma membrane Ca2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranes","volume":"281","author":"Sepulveda","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0415","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1152\/jn.00570.2006","article-title":"Dynamic synchronization of Purkinje cell simple spikes","volume":"96","author":"Shin","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0420","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tins.2005.08.004","article-title":"Synaptic pathways in neural microcircuits","volume":"28","author":"Silberberg","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0425","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0021-9258(18)69190-2","article-title":"Regulation of erythrocyte Ca2+ pump activity by protein kinase C","volume":"263","author":"Smallwood","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0430","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1126\/science.1083661","article-title":"Disrupted timing of discontinuous but not continuous movements by cerebellar lesions","volume":"300","author":"Spencer","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neulet.2017.11.005_bib0435","doi-asserted-by":"crossref","first-page":"e1000238","DOI":"10.1371\/journal.pgen.1000238","article-title":"The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss","volume":"4","author":"Spiden","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0440","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/physrev.00028.2016","article-title":"The plasma membrane calcium ATPases and their role as major new players in human disease","volume":"97","author":"Stafford","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2017.11.005_bib0445","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0169-328X(92)90229-5","article-title":"Plasma membrane Ca(2+)-ATPase isoforms: distribution of mRNAs in rat brain by in situ hybridization","volume":"16","author":"Stahl","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0450","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(96)01282-6","article-title":"Immunolocalization of the plasma membrane Ca2+ pump isoforms in the rat brain","volume":"748","author":"Stauffer","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.11.005_bib0455","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/1284","article-title":"Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice","volume":"19","author":"Street","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2017.11.005_bib0460","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/1566524043360735","article-title":"Calcium pumps of plasma membrane and cell interior","volume":"4","author":"Strehler","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.neulet.2017.11.005_bib0465","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.2001.81.1.21","article-title":"Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps","volume":"81","author":"Strehler","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2017.11.005_bib0470","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1006\/bbrc.1999.1102","article-title":"A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami","volume":"261","author":"Takahashi","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2017.11.005_bib0475","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1210\/en.2015-2029","article-title":"Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3","volume":"157","author":"Tauber","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2017.11.005_bib0480","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/jn.1968.31.5.785","article-title":"Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey","volume":"31","author":"Thach","year":"1968","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0485","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.ne.15.030192.002155","article-title":"The cerebellum and the adaptive coordination of movement","volume":"15","author":"Thach","year":"1992","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0490","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature11539","article-title":"A bimodular mechanism of calcium control in eukaryotes","volume":"491","author":"Tidow","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.11.005_bib0495","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11334","article-title":"Genome-wide association study indicates two novel resistance loci for severe malaria","volume":"489","author":"Timmann","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.11.005_bib0500","doi-asserted-by":"crossref","first-page":"11949","DOI":"10.1073\/pnas.90.24.11949","article-title":"Immunocytochemical localization of the plasma membrane calcium pump, calbindin-D28k, and parvalbumin in Purkinje cells of avian and mammalian cerebellum","volume":"90","author":"Tolosa de Talamoni","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.005_bib0505","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/35015017","article-title":"Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6\u202fA resolution","volume":"405","author":"Toyoshima","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.11.005_bib0510","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.conb.2011.01.009","article-title":"The metamorphosis of the developing cerebellar microcircuit","volume":"21","author":"van Welie","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0515","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0021-9258(17)42082-5","article-title":"Regulatory region of plasma membrane Ca2+ pump. 28 residues suffice to bind calmodulin but more are needed for full auto-inhibition of the activity","volume":"269","author":"Verma","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0520","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1074\/jbc.274.1.527","article-title":"Protein kinase C phosphorylates plasma membrane Ca2+ pump isoform 4a at its calmodulin binding domain","volume":"274","author":"Verma","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"December (12)","key":"10.1016\/j.neulet.2017.11.005_bib0525","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1016\/j.bbadis.2017.08.006","article-title":"A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: biochemical characterization of the pump defect","volume":"1863","author":"Vicario","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2017.11.005_bib0530","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0021-9258(18)52395-4","article-title":"The calmodulin-binding domain mediates the self-association of the plasma membrane Ca2+ pump","volume":"266","author":"Vorherr","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2017.11.005_bib0535","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1648","article-title":"Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia","volume":"9","author":"Walter","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.005_bib0540","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/ncb1302","article-title":"The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R","volume":"7","author":"White","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2017.11.005_bib0545","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.113.01733","article-title":"Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas","volume":"63","author":"Williams","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.neulet.2017.11.005_bib0550","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.1073\/pnas.1207488109","article-title":"Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis","volume":"109","author":"Zanni","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.005_bib0555","doi-asserted-by":"crossref","first-page":"8070","DOI":"10.1021\/bi00487a012","article-title":"Mapping of functional domains in the plasma membrane Ca2+ pump using trypsin proteolysis","volume":"29","author":"Zvaritch","year":"1990","journal-title":"Biochemistry"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T16:00:58Z","timestamp":1719590458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017309035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":111,"alternative-id":["S0304394017309035"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.11.005","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PMCA pumps in genetically determined neuronal pathologies","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}