{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:04:59Z","timestamp":1761102299152},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["19390066","26460114","17J11608"],"award-info":[{"award-number":["19390066","26460114","17J11608"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.neulet.2017.11.028","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T20:18:32Z","timestamp":1511554712000},"page":"140-146","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice"],"prefix":"10.1016","volume":"665","author":[{"given":"Ikutaro","family":"Honda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sokichi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Takahama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.11.028_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/dvg.20228","article-title":"Characterization of a mouse strain expressing cre recombinase from the 30 untranslated region of the dopamine transporter locus","volume":"44","author":"B\u00e4ckman","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.neulet.2017.11.028_bib0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature11713","article-title":"Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons","volume":"493","author":"Chaudhury","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.11.028_bib0015","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neulet.2017.11.028_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nn1181","article-title":"Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system","volume":"7","author":"Cruz","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.028_bib0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroscience.2013.07.044","article-title":"Tipepidine activates VTA dopamine neuron via inhibiting dopamine D2 receptor-mediated inward rectifying K\u207a current","volume":"252","author":"Hamasaki","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.11.028_bib0030","first-page":"118","article-title":"Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization","volume":"284","author":"Hamao","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.11.028_bib0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0165-0173(98)00018-6","article-title":"Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB\/ATF proteins","volume":"28","author":"Herdegen","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neulet.2017.11.028_bib0040","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1523\/JNEUROSCI.16-11-03559.1996","article-title":"IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain","volume":"16","author":"Karschin","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.028_bib0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainres.2013.03.034","article-title":"Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain","volume":"1513","author":"Kawahara","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2017.11.028_bib0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbr.2009.07.004","article-title":"The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats","volume":"205","author":"Kawaura","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2017.11.028_bib0055","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbr.2011.09.031","article-title":"Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test","volume":"226","author":"Kawaura","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2017.11.028_bib0060","series-title":"Discovery of novel antidepressant-like effect of tipepidine possessing inhibitory action of GIRK channel and pharmacological analysis of the action. Ph.D. Thesis of Kumamoto University","article-title":"text in Japanese with English abstract)","author":"Kawaura","year":"2012"},{"key":"10.1016\/j.neulet.2017.11.028_bib0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbr.2015.12.008","article-title":"Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats","volume":"302","author":"Kawaura","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2017.11.028_bib0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00210-010-0521-x","article-title":"Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats","volume":"382","author":"Kitamura","year":"2010","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.neulet.2017.11.028_bib0075","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1523\/JNEUROSCI.5051-14.2015","article-title":"GIRK channels modulate opioid-induced motor activity in a cell type- and subunit-dependent manner","volume":"35","author":"Kotecki","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2017.11.028_bib0080","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuron.2008.01.022","article-title":"Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system","volume":"57","author":"Lammel","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2017.11.028_bib0085","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv051","article-title":"Deletion of GIRK2 subunit of GIRK channels alters the 5-HT1A receptor-mediated signaling and results in a depression-resistant behavior","volume":"18","author":"Llamosas","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2017.11.028_bib0090","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"Mali","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neulet.2017.11.028_bib0095","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/npp.2016.138","article-title":"Selective ablation of GIRK channels in dopamine neurons alters behavioral effects of cocaine in mice","volume":"42","author":"McCall","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2017.11.028_bib0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00335-013-9452-4","article-title":"Gene-trap mutagenesis using Mol\/MSM-1 embryonic stem cells from MSM\/Ms mice","volume":"24","author":"Nakahara","year":"2013","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.neulet.2017.11.028_bib0105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2147\/NDT.S63075","article-title":"Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study","volume":"10","author":"Sasaki","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neulet.2017.11.028_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/neu.2015.43","article-title":"Effects of add-on tipepidine on treatment-resistant depression: an open-label pilot trial","volume":"28","author":"Shirayama","year":"2016","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.neulet.2017.11.028_bib0115","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1073\/pnas.94.3.923","article-title":"Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2","volume":"94","author":"Signorini","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2017.11.028_bib0120","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1254\/jphs.12R07CP","article-title":"Multiple pharmacological actions of centrally acting antitussives\u2013do they target G protein-coupled inwardly rectifying K+ (GIRK) channels?","volume":"120","author":"Takahama","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.neulet.2017.11.028_bib0125","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature11740","article-title":"Dopamine neurons modulate neural encoding and expression of depression-related behaviour","volume":"493","author":"Tye","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2017.11.028_bib0130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1993.1458","article-title":"A novel ES cell line, TT2, with high germline-differentiating potency","volume":"214","author":"Yagi","year":"1993","journal-title":"Anal. Biochem."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:28:57Z","timestamp":1536121737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017309278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":26,"alternative-id":["S0304394017309278"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.11.028","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}