{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:50:19Z","timestamp":1789617019717,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.neulet.2017.12.013","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T09:34:37Z","timestamp":1512639277000},"page":"195-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil"],"prefix":"10.1016","volume":"665","author":[{"given":"Hideo","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masachika","family":"Shudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Gyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Hato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2017.12.013_bib0005","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3109\/00016489.2014.919406","article-title":"Idiopathic sudden sensorineural hearing loss in Japan","volume":"134","author":"Nakashima","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(97)00462-X","article-title":"Efflux of glutamate into the perilymph of the cochlea following transient ischemia in gerbil","volume":"230","author":"Hakuba","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1096-9861(20000306)418:2<217::AID-CNE7>3.0.CO;2-L","article-title":"Hearing loss and glutamate efflux in the perilymph following transient cochlear ischemia","volume":"418","author":"Hakuba","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5319\/wjo.v3.i1.1","article-title":"Experimental study of transient cochlear ischemia as a cause of sudden deafness","volume":"3","author":"Gyo","year":"2013","journal-title":"World J. Otorhinolaryngol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0025","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2017.12.013_bib0030","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/mds.25375","article-title":"Pilot study of H2 therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial","volume":"28","author":"Yoritaka","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2017.12.013_bib0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nutres.2008.01.008","article-title":"Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance","volume":"28","author":"Kajiyama","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0040","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.intimp.2014.06.001","article-title":"Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study","volume":"21","author":"Ishibashi","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-9912-1-11","article-title":"Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors","volume":"1","author":"Kang","year":"2011","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2014.07.025","article-title":"Hydrogen protects auditory hair cells from cisplatin-induced free radicals","volume":"579","author":"Kikkawa","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2010.09.064","article-title":"Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs","volume":"487","author":"Lin","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neures.2014.08.009","article-title":"Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species","volume":"89","author":"Kurioka","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0065","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0306-4522(93)90343-E","article-title":"Differential vulnerability in the hindbrain neurons and local cerebral blood flow during bilateral vertebral occlusion in gerbils","volume":"56","author":"Hata","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2017.12.013_bib0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/cne.10479","article-title":"Transient cochlear ischemia causes delayed cell death in the organ of Corti and the spiral ganglion: an experimental study in gerbils","volume":"456","author":"Koga","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.heares.2006.08.008","article-title":"Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine","volume":"226","author":"Coleman","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0080","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2005.08.038","article-title":"Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea","volume":"391","author":"Morizane","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3940(99)00534-0","article-title":"Expression of inducible nitric oxide synthase immunoreactivity in rat brain following chronic hypoxia: effect of aminoguanidine","volume":"271","author":"Niwa","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr Physiol."},{"key":"10.1016\/j.neulet.2017.12.013_bib0095","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1161\/CIRCULATIONAHA.114.011848","article-title":"Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest Independently of targeted temperature management","volume":"130","author":"Hayashida","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.neulet.2017.12.013_bib0100","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1080\/10715760902870603","article-title":"Hydrogen rich saline protects against intestinal ischemia\/reperfusion injury in rats","volume":"43","author":"Zheng","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ki.2009.421","article-title":"Oral hydrogen water prevents chronic allograft nephropathy in rats","volume":"77","author":"Cardinal","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.neulet.2017.12.013_bib0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2008.05.077","article-title":"Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model","volume":"441","author":"Cai","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2017.12.013_bib0115","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3164\/jcbn.09-100","article-title":"Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study","volume":"46","author":"Nakao","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.neulet.2017.12.013_bib0120","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/hep.25782","article-title":"Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice","volume":"56","author":"Kawai","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.neulet.2017.12.013_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2045-9912-2-27","article-title":"Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study","volume":"2","author":"Ishibashi","year":"2012","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.neulet.2017.12.013_bib0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3810\/pgm.2014.09.2813","article-title":"Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries","volume":"126","author":"Ostojic","year":"2014","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.neulet.2017.12.013_bib0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.heares.2006.10.006","article-title":"Mechanism of noise induced hearing loss indicate multiple methods of prevention","volume":"226","author":"LePrell","year":"2007","journal-title":"Hear. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394017309862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:30:21Z","timestamp":1536121821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394017309862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"alternative-id":["S0304394017309862"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2017.12.013","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2017.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}