{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:04:20Z","timestamp":1790615060562,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15NS096562"],"award-info":[{"award-number":["1R15NS096562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.neulet.2018.02.021","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:59:33Z","timestamp":1518440373000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Dendrite growth and the effect of ectopic Rheb expression on cortical neurons"],"prefix":"10.1016","volume":"671","author":[{"given":"Aidan M.","family":"Sokolov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M.","family":"Seluzicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.02.021_bib0005","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2018.02.021_bib0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"Curatolo","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijdevneu.2013.02.008","article-title":"A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits","volume":"31","author":"Feliciano","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0020","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1750-3639.2009.00341.x","article-title":"Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors","volume":"20","author":"Boer","year":"2010","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0025","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1212\/WNL.0b013e3181e04325","article-title":"Biallelic TSC gene inactivation in tuberous sclerosis complex","volume":"74","author":"Crino","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2018.02.021_bib0030","doi-asserted-by":"crossref","DOI":"10.1172\/JCI44909","article-title":"Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice","volume":"121","author":"Feliciano","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2018.02.021_bib0035","first-page":"47","article-title":"Tuberous sclerosis: a Golgi study of cortical tuber","volume":"3","author":"Ferrer","year":"1984","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00401-012-0950-3","article-title":"Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex","volume":"123","author":"Marcotte","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0045","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ana.21342","article-title":"Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers","volume":"63","author":"Talos","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2011.10.002","article-title":"Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations","volume":"244","author":"Wong","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0055","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nm.3982","article-title":"An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development","volume":"21","author":"Baek","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2018.02.021_bib0060","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ana.24368","article-title":"Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations","volume":"77","author":"Baulac","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0065","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1111\/epi.13307","article-title":"Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex gene NPRL3","volume":"57","author":"Korenke","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.neulet.2018.02.021_bib0070","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/ana.24127","article-title":"DEPDC5 mutations in genetic focal epilepsies of childhood","volume":"75","author":"Lal","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nm.3824","article-title":"Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy","volume":"21","author":"Lim","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2018.02.021_bib0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2012.03.010","article-title":"Somatic activation of AKT3 causes hemispheric developmental brain malformations","volume":"74","author":"Poduri","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2018.02.021_bib0085","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/ana.24126","article-title":"Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations","volume":"75","author":"Scheffer","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ana.24502","article-title":"Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3","volume":"79","author":"Sim","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0095","article-title":"mTOR signaling, cold spring harb","volume":"4","author":"Laplante","year":"2012","journal-title":"Perspect. Biol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0100","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1073\/pnas.95.4.1432","article-title":"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1","volume":"95","author":"Burnett","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0105","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1101\/gad.13.11.1422","article-title":"Regulation of 4E-BP1 phosphorylation: a novel two step mechanism","volume":"13","author":"Gingras","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2018.02.021_bib0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11083","article-title":"A unifying model for mTORC1-mediated regulation of mRNA translation","volume":"485","author":"Thoreen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2018.02.021_bib0115","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0092-8674(92)90643-Q","article-title":"Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases","volume":"69","author":"Chung","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2018.02.021_bib0120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0125","first-page":"973","article-title":"Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase","volume":"257","author":"Price","year":"1992","journal-title":"Source Sci. New Ser."},{"key":"10.1016\/j.neulet.2018.02.021_bib0130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2016.11.017","article-title":"Molecular neurobiology of mTOR","volume":"341","author":"Switon","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.02.021_bib0135","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2018.02.021_bib0140","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2018.02.021_bib0145","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","article-title":"Insulin activation of Rheb, a mediator of mTOR\/S6 K\/4E-BP signaling, is inhibited by TSC1 and 2","volume":"11","author":"Garami","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neulet.2018.02.021_bib0150","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/hmg\/dds414","article-title":"Deletion of rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex","volume":"22","author":"Carson","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.02.021_bib0155","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1523\/JNEUROSCI.3294-12.2013","article-title":"Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis","volume":"33","author":"Cloetta","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0160","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1242\/dev.108282","article-title":"mTOR regulates brain morphogenesis by mediating GSK3 signaling","volume":"141","author":"Ka","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.neulet.2018.02.021_bib0165","doi-asserted-by":"crossref","first-page":"14368","DOI":"10.1073\/pnas.2336098100","article-title":"Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1","volume":"100","author":"Cammalleri","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0170","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1523\/JNEUROSCI.2270-05.2005","article-title":"Control of dendritic arborization by the phosphoinositide \u2013 3 \u0408 \u2013 kinase \u2013 Akt \u2013 mammalian target of rapamycin pathway","volume":"25","author":"Jaworski","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0175","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.1523\/JNEUROSCI.2284-05.2005","article-title":"Regulation of dendritic morphogenesis by ras-PI3K-Akt-mTOR and ras-MAPK signaling pathways","volume":"25","author":"Kumar","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0180","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1840-12.2013","article-title":"Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons","volume":"33","author":"Lafourcade","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0185","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1523\/JNEUROSCI.1427-04.2004","article-title":"Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites","volume":"24","author":"Takei","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0190","doi-asserted-by":"crossref","first-page":"30240","DOI":"10.1074\/jbc.M112.374405","article-title":"Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons","volume":"287","author":"Urbanska","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.02.021_bib0195","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddr511","article-title":"Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell TSC1 deletion","volume":"21","author":"Feliciano","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.02.021_bib0200","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11753","article-title":"Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement","volume":"7","author":"Hsieh","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2018.02.021_bib0205","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.1605740113","article-title":"Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration","volume":"113","author":"Lin","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0210","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00933-6","article-title":"Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability","volume":"8","author":"Reijnders","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2018.02.021_bib0215","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1093\/hmg\/ddv295","article-title":"Activating the translational repressor 4E-BP or reducing S6K-GSK3\u03b2 activity prevents accelerated axon growth induced by hyperactive mTOR in vivo","volume":"24","author":"Gong","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.02.021_bib0220","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.celrep.2015.07.013","article-title":"Impaired Reelin-Dab1 signaling contributes to neuronal migration deficits of tuberous sclerosis complex","volume":"12","author":"Moon","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2018.02.021_bib0225","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2013.00104","article-title":"Anterior Cingulate epilepsy: mechanisms and modulation","volume":"7","author":"Chang","year":"2014","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0230","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/brain\/awv043","article-title":"Somatosensory cortex functional connectivity abnormalities in autism show opposite trends, depending on direction and spatial scale","volume":"138","author":"Khan","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2018.02.021_bib0235","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1528-1157.1970.tb03865.x","article-title":"Criteria for identifying cingulate epilepsies*","volume":"11","author":"Mazars","year":"1970","journal-title":"Epilepsia"},{"key":"10.1016\/j.neulet.2018.02.021_bib0240","doi-asserted-by":"crossref","first-page":"e0151879","DOI":"10.1371\/journal.pone.0151879","article-title":"Functional connectivity of the caudal anterior cingulate cortex is decreased in autism","volume":"11","author":"Zhou","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.02.021_bib0245","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","article-title":"Pten regulates neuronal arborization and social interaction in mice","volume":"50","author":"Kwon","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2018.02.021_bib0250","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1523\/JNEUROSCI.0955-08.2008","article-title":"Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function","volume":"28","author":"Meikle","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.02.021_bib0255","article-title":"New and improved tools for in utero electroporation studies of developing cerebral cortex","volume":"19","author":"Lo Turco","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neulet.2018.02.021_bib0260","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1440-169X.2008.01043.x","article-title":"Labeling embryonic mouse central nervous system cells by in utero electroporation","volume":"50","author":"Tabata","year":"2008","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.neulet.2018.02.021_bib0265","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/1073858411399925","article-title":"In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors","volume":"18","author":"Taniguchi","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neulet.2018.02.021_bib0270","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022442","article-title":"mTOR signaling in epilepsy: insights from malformations of cortical development","volume":"5","author":"Crino","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018300971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018300971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:22:45Z","timestamp":1759609365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018300971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":54,"alternative-id":["S0304394018300971"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.02.021","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrite growth and the effect of ectopic Rheb expression on cortical neurons","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}