{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:10:54Z","timestamp":1772831454910,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Shanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2014021038-1"],"award-info":[{"award-number":["2014021038-1"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Shanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2014011040-2"],"award-info":[{"award-number":["2014011040-2"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015306","name":"Fund for Shanxi Key Subjects Construction","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015306","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202520"],"award-info":[{"award-number":["81202520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.neulet.2018.05.002","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T11:16:47Z","timestamp":1525173407000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice"],"prefix":"10.1016","volume":"678","author":[{"given":"Yan-Ying","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Lu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Long","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Qin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Fen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.05.002_bib0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.expneurol.2016.01.023","article-title":"The role of the PI3\u202fK\/Akt\/mTOR pathway in glial scar formation following spinal cord injury","volume":"278","author":"Chen","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.05.002_bib0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fnsys.2015.00163","article-title":"Effects of rapamycin treatment on neurogenesis and synaptic reorganization in the dentate gyrus after controlled cortical impact injury in mice","volume":"9","author":"Butler","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuint.2015.03.001","article-title":"Inhibition of mTOR pathway restrains astrocyte proliferation migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation","volume":"83\u201384","author":"Li","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2018.05.002_bib0020","doi-asserted-by":"crossref","first-page":"15347","DOI":"10.1523\/JNEUROSCI.1935-14.2014","article-title":"Mammalian target of rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS","volume":"34","author":"Lee","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0025","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1093\/brain\/awl165","article-title":"Essential protective roles of reactive astrocytes in traumatic brain injury","volume":"129","author":"Myer","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2018.05.002_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/neu.2014.3469","article-title":"Genetic activation of mTORC1 signaling worsens neurocognitive outcome after traumatic brain injury","volume":"32","author":"Rozas","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neulet.2018.05.002_bib0035","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0040","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2012.09.039","article-title":"Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons","volume":"1486","author":"Wu","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2018.05.002_bib0045","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1089\/neu.2012.2513","article-title":"Roles of chondroitin sulfate and dermatan sulfate in the formation of a lesion scar and axonal regeneration after traumatic injury of the mouse brain","volume":"30","author":"Li","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neulet.2018.05.002_bib0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/neu.2015.3899","article-title":"Beneficial effects of early mTORC1 inhibition after traumatic brain injury","volume":"33","author":"Nikolaeva","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neulet.2018.05.002_bib0055","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1097\/TA.0b013e3181f31b06","article-title":"Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats","volume":"69","author":"Kuo","year":"2010","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.neulet.2018.05.002_bib0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jss.2014.09.026","article-title":"Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis","volume":"194","author":"Ding","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.neulet.2018.05.002_bib0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2009.12.032","article-title":"PTEN\/mTOR and axon regeneration","volume":"223","author":"Park","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.05.002_bib0070","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neulet.2018.05.002_bib0075","first-page":"1747","article-title":"Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain","volume":"56","author":"Shen","year":"2008","journal-title":"Neural Inj. Funct. Reconstruct."},{"key":"10.1016\/j.neulet.2018.05.002_bib0080","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.expneurol.2014.10.023","article-title":"Transforming growth factor \u03b2-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways","volume":"263","author":"Jahan","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.05.002_bib0085","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2016.03.053","article-title":"Effects of rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion","volume":"620","author":"Chi","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2018.05.002_bib0090","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneurol.2016.81","article-title":"The mTOR signalling cascade: paving new roads to cure neurological disease","volume":"12","author":"Crino","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neulet.2018.05.002_bib0095","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.3892\/mmr.2015.4407","article-title":"Rapamycin protects neurons from brain contusion-induced inflammatory reaction via modulation of microglial activation","volume":"12","author":"Song","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neulet.2018.05.002_bib0100","first-page":"8","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0105","doi-asserted-by":"crossref","first-page":"15356","DOI":"10.1038\/srep15356","article-title":"Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration","volume":"5","author":"Liao","year":"2015","journal-title":"Sci. Rep.-UK"},{"key":"10.1016\/j.neulet.2018.05.002_bib0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jns.2004.01.006","article-title":"Anatomical and functional recovery by embryonic stem cell-derived neural tissue of a mouse model of brain damage","volume":"219","author":"Chiba","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0115","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1523\/JNEUROSCI.4103-08.2009","article-title":"The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord","volume":"29","author":"Codeluppi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0120","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.nbd.2006.12.003","article-title":"Rapamycin is a neuroprotective treatment for traumatic brain injury","volume":"26","author":"Erlich","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2018.05.002_bib0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnint.2016.00007","article-title":"Role of glia in memory deficits following traumatic brain injury: biomarkers of glia dysfunction","volume":"10","author":"Sajja","year":"2016","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0130","first-page":"1","article-title":"Deletion of mTOR in reactive astrocytes suppresses chronic seizures in a mouse model of temporal lobe epilepsy","volume":"54","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2018.05.002_bib0135","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/jcbfm.2014.113","article-title":"Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice","volume":"34","author":"Zhu","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2018.05.002_bib0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mcn.2015.04.006","article-title":"Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury","volume":"68","author":"Goldshmit","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.002_bib0145","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.celrep.2017.04.047","article-title":"Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation","volume":"19","author":"Shinozaki","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2018.05.002_bib0150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2017.05.004","article-title":"Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia-reperfusion brain injury","volume":"356","author":"Zhu","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.05.002_bib0155","first-page":"101","article-title":"Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in rats","volume":"8","author":"Sun","year":"2013","journal-title":"Neural Regen. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401830329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401830329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:22:30Z","timestamp":1759609350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439401830329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":31,"alternative-id":["S030439401830329X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.05.002","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}